Core B: Data and Research Methods

项目摘要 尽管阿片类药物对公共健康具有重要意义，但针对阿片类药物使用障碍和过量使用的干预措施经常受到影响 由于缺乏严谨的设计和评估。在关于阿片类药物和过量使用的科布雷第二阶段中， 数据和研究方法(DRM)核心将继续支持Cobre项目负责人和试点调查人员 在克服传统上阻碍方法、分析和翻译的挑战方面 研究项目的成功和对公众健康的影响。通过提供量化的专业知识、研究基础设施、 和技术资源，DRM核心极大地加强了Cobre生产的工作的严谨性 调查人员，提高他们的数据使用/管理能力，并提供与 整个研究都是为了实践管道。DRM核心服务包括：1)研究设计的方法学咨询 抽样、匹配、调查发展和数据统一等问题；2)生物统计学支持，如 由于使用了统计模型、模型构建程序、模型规范和处理缺失的方法 数据；3)“仪表板”和其他可视化服务，以生成用户友好、交互的数据输出 传播和翻译信息；4)提供符合HIPAA的数据管理系统，该系统 将提供多层访问、备份和身份验证；5)提供全州范围内的访问和链接 与过量用药有关的数据库，以及记录匹配服务，以丰富各项目的成果；以及6) 提供有关方法学、计算性和分析性思想的培训和促进交流 对过量和阿片类药物相关危害的研究。在第二阶段，数字版权管理核心将提供最佳做法方面的专门知识 在研究过程的所有阶段以种族/民族健康公平为中心，并将支持 研究人员将开放科学原则应用到他们的工作中。 DRM核心主任布兰登·马歇尔博士是美国疾病控制与预防中心和美国国立卫生研究院资助的知名研究员，拥有广泛的 在队列研究设计、调查开发和使用先进的定量方法方面的经验，包括 模拟方法，评估非随机化的公共卫生干预措施。他的领导力将是 辅以训练有素的人员，具有流行病学方法、项目管理、数据库方面的专业知识 开发、编程、数据可视化和生物统计学。

Project Summary Despite their public health significance, interventions focusing on opioid use disorder and overdose often suffer from a lack of rigorous design and evaluation. Throughout phase II of the COBRE on Opioids & Overdose, the Data and Research Methods (DRM) Core will continue to support COBRE project leaders and pilot investigators in overcoming the methodological, analytical, and translational challenges that have traditionally stymied research project success and public health impact. By providing quantitative expertise, research infrastructure, and technological resources, the DRM Core greatly strengthens the rigor of the work produced by COBRE investigators, enhances their data use/management capacity, and provides training opportunities relevant to the entire research to practice pipeline. DRM Core services include: 1) methodological consultation on study design issues such as sampling, matching, survey development, and data harmonization; 2) biostatistical support, such as the use of statistical models, model-building procedures, model specification, and methods to handle missing data; 3) “dashboarding” and other visualization services to generate user-friendly, interactive data outputs for dissemination and translation of information; 4) providing a HIPAA-compliant data management system which will provide multi-tier access, back-ups, and de-identification; 5) providing access and linkage to statewide overdose-related databases, as well as record matching services to enrich outcomes across projects; and 6) providing training on and facilitating the exchange of methodological, computational, and analytic ideas related to the study of overdose and opioid-related harms. In phase II, the DRM Core will offer expertise on best practices for centering racial/ethnic health equity throughout all stages of the research process, and will support investigators as they apply open science principles to their work. DRM Core Director Dr. Brandon Marshall is an established CDC- and NIH-funded investigator with extensive experience in cohort study design, survey development, and the use of advanced quantitative methods, including simulation approaches, to evaluate non-randomized public health interventions. His leadership will be supplemented by highly trained staff with expertise in epidemiological methods, project management, database development, programming, data visualization, and biostatistics.