Core B: Data and Research Methods

项目摘要 尽管它们具有公共卫生意义，但侧重于阿片类药物使用障碍和过量的干预措施往往受到影响， 缺乏严格的设计和评估。在COBRE关于阿片类药物和过量的第二阶段， 数据和研究方法（DRM）核心将继续支持COBRE项目领导人和试点研究人员 在克服传统上阻碍我们的方法论、分析和翻译挑战方面， 研究项目的成功和公共卫生影响。通过提供定量的专业知识，研究基础设施， 和技术资源，DRM核心大大加强了COBRE工作的严谨性 调查员，提高他们的数据使用/管理能力，并提供与 整个研究到实践的管道。DRM核心服务包括：1）研究设计方法咨询 抽样、匹配、调查开发和数据协调等问题; 2）生物统计支持， 作为统计模型的使用，模型建立程序，模型规范，以及处理缺失的方法 数据; 3）“仪表板”和其他可视化服务，以生成用户友好的交互式数据输出， 信息的传播和翻译; 4）提供符合HIPAA的数据管理系统， 将提供多层访问，备份和去识别; 5）提供全州范围的访问和链接 过量相关的数据库，以及记录匹配服务，以丰富跨项目的成果;以及6） 提供培训，促进方法，计算和分析思想的交流， 过量服用和阿片类药物相关危害的研究。在第二阶段，数字版权管理核心将提供有关最佳做法的专门知识 在整个研究过程的所有阶段，以种族/民族健康公平为中心，并将支持 研究人员将开放科学原则应用于他们的工作。 DRM核心主任布兰登马歇尔博士是一个既定的疾病预防控制中心和国家卫生研究院资助的研究人员与广泛的 在队列研究设计、调查开发和使用先进定量方法方面的经验，包括 模拟方法，以评估非随机公共卫生干预措施。他的领导将是 由在流行病学方法、项目管理、数据库、 开发、编程、数据可视化和生物统计学。

Project Summary Despite their public health significance, interventions focusing on opioid use disorder and overdose often suffer from a lack of rigorous design and evaluation. Throughout phase II of the COBRE on Opioids & Overdose, the Data and Research Methods (DRM) Core will continue to support COBRE project leaders and pilot investigators in overcoming the methodological, analytical, and translational challenges that have traditionally stymied research project success and public health impact. By providing quantitative expertise, research infrastructure, and technological resources, the DRM Core greatly strengthens the rigor of the work produced by COBRE investigators, enhances their data use/management capacity, and provides training opportunities relevant to the entire research to practice pipeline. DRM Core services include: 1) methodological consultation on study design issues such as sampling, matching, survey development, and data harmonization; 2) biostatistical support, such as the use of statistical models, model-building procedures, model specification, and methods to handle missing data; 3) “dashboarding” and other visualization services to generate user-friendly, interactive data outputs for dissemination and translation of information; 4) providing a HIPAA-compliant data management system which will provide multi-tier access, back-ups, and de-identification; 5) providing access and linkage to statewide overdose-related databases, as well as record matching services to enrich outcomes across projects; and 6) providing training on and facilitating the exchange of methodological, computational, and analytic ideas related to the study of overdose and opioid-related harms. In phase II, the DRM Core will offer expertise on best practices for centering racial/ethnic health equity throughout all stages of the research process, and will support investigators as they apply open science principles to their work. DRM Core Director Dr. Brandon Marshall is an established CDC- and NIH-funded investigator with extensive experience in cohort study design, survey development, and the use of advanced quantitative methods, including simulation approaches, to evaluate non-randomized public health interventions. His leadership will be supplemented by highly trained staff with expertise in epidemiological methods, project management, database development, programming, data visualization, and biostatistics.