Core B: Data and Research Methods

项目概要 尽管对公共卫生具有重要意义，但针对阿片类药物使用障碍和过量用药的干预措施往往会受到影响 缺乏严格的设计和评估。在 COBRE 关于阿片类药物和过量用药的第二阶段中， 数据和研究方法 (DRM) 核心将继续支持 COBRE 项目领导者和试点研究人员 克服传统上阻碍的方法论、分析和转化挑战 研究项目的成功和公共卫生影响。通过提供定量专业知识、研究基础设施， 和技术资源，DRM Core 大大加强了 COBRE 工作的严谨性 调查人员，增强他们的数据使用/管理能力，并提供与调查相关的培训机会 整个研究到实践的管道。 DRM核心服务包括：1）研究设计的方法学咨询 抽样、匹配、调查开展和数据协调等问题； 2）生物统计支持，例如 使用统计模型、模型构建程序、模型规范和处理缺失的方法 数据； 3）“仪表板”和其他可视化服务，为用户生成用户友好的交互式数据输出 信息传播和翻译； 4）提供符合HIPAA标准的数据管理系统 将提供多层访问、备份和去识别化； 5）提供全州范围内的访问和链接 与药物过量相关的数据库以及记录匹配服务，以丰富跨项目的成果；和 6) 提供培训并促进相关方法、计算和分析思想的交流 研究过量和阿片类药物相关危害。在第二阶段，DRM 核心将提供最佳实践方面的专业知识 在研究过程的所有阶段以种族/族裔健康公平为中心，并将支持 研究人员将开放科学原则应用于他们的工作。 DRM 核心主任 Brandon Marshall 博士是一位由 CDC 和 NIH 资助的资深研究员，拥有广泛的研究经验 队列研究设计、调查开发和使用先进定量方法的经验，包括 模拟方法，评估非随机公共卫生干预措施。他的领导力将是 辅之以训练有素的工作人员，他们具有流行病学方法、项目管理、数据库方面的专业知识 开发、编程、数据可视化和生物统计学。

Project Summary Despite their public health significance, interventions focusing on opioid use disorder and overdose often suffer from a lack of rigorous design and evaluation. Throughout phase II of the COBRE on Opioids & Overdose, the Data and Research Methods (DRM) Core will continue to support COBRE project leaders and pilot investigators in overcoming the methodological, analytical, and translational challenges that have traditionally stymied research project success and public health impact. By providing quantitative expertise, research infrastructure, and technological resources, the DRM Core greatly strengthens the rigor of the work produced by COBRE investigators, enhances their data use/management capacity, and provides training opportunities relevant to the entire research to practice pipeline. DRM Core services include: 1) methodological consultation on study design issues such as sampling, matching, survey development, and data harmonization; 2) biostatistical support, such as the use of statistical models, model-building procedures, model specification, and methods to handle missing data; 3) “dashboarding” and other visualization services to generate user-friendly, interactive data outputs for dissemination and translation of information; 4) providing a HIPAA-compliant data management system which will provide multi-tier access, back-ups, and de-identification; 5) providing access and linkage to statewide overdose-related databases, as well as record matching services to enrich outcomes across projects; and 6) providing training on and facilitating the exchange of methodological, computational, and analytic ideas related to the study of overdose and opioid-related harms. In phase II, the DRM Core will offer expertise on best practices for centering racial/ethnic health equity throughout all stages of the research process, and will support investigators as they apply open science principles to their work. DRM Core Director Dr. Brandon Marshall is an established CDC- and NIH-funded investigator with extensive experience in cohort study design, survey development, and the use of advanced quantitative methods, including simulation approaches, to evaluate non-randomized public health interventions. His leadership will be supplemented by highly trained staff with expertise in epidemiological methods, project management, database development, programming, data visualization, and biostatistics.