Core B: Data and Research Methods

核心 B：数据和研究方法

• 批准号: 10256005
• 负责人: Brandon David Lewis Marshall
• 金额: $ 42.73万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10256005
• 关键词: Address; Area; Back; Biometry; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Clinical; Cohort Studies; Communities; Consultations; Data; Data Collection; Data Management Resources; Data Set; Data Sources; Data Storage and Retrieval; Databases; Development; Drug usage; Educational workshop; Ensure; Environment; Epidemiologic Methods; Epidemiology; Evaluation; Fertilization; Funding; Goals; Health; Health Insurance Portability and Accountability Act; Health Professional; Hospitals; Infrastructure; Intervention; Language; Leadership; Link; Maps; Metadata; Methodology; Methods; Modeling; Modernization; Opioid; Outcome; Outcome Assessment; Output; Overdose; Policies; Population; Procedures; Public Health; Quality Control; Records; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Rhode Island; Sampling; Secure; Services; Software Tools; Standardization; Statistical Data Interpretation; Statistical Models; Surveys; Time; Training; Translating; Translations; Twin Multiple Birth; United States National Institutes of Health; Universities; Visualization; Work; career development; computerized tools; dashboard; data exchange; data harmonization; data integration; data streams; data visualization; design; disorder prevention; experience; innovation; interdisciplinary approach; member; model building; novel; opioid epidemic; opioid overdose; opioid use disorder; overdose death; overdose prevention; population based; public health intervention; repository; simulation; success; tool; user-friendly; working group

Project Summary Despite their public health significance, interventions focusing on opioid use disorder and overdose prevention often suffer from a lack of rigorous design and evaluation. The Data and Research Methods (DRM) Core will support COBRE Project Leaders and pilot investigators in overcoming the methodological, analytical, and translational challenges that have traditionally stymied research project success and public health impact. By providing quantitative expertise, research infrastructure, and technological resources, the DRM Core will strengthen the quality of the work produced by COBRE Project Leaders, and enhance their data use/management capacity. DRM Core services will include: 1) methodological consultation on study design issues such as sampling, matching, survey development, and data harmonization; 2) statistical support, such as the use of statistical models, model-building procedures, model specification, and methods to handle missing data; 3) “dashboarding” and other visualization services to generate user-friendly, interactive data outputs for dissemination and translation of information; 4) providing a HIPAA-compliant data management system which will provide multi-tier access, back-ups, and de-identification; 5) providing access and linkage to existing and new statewide overdose-related databases, as well as record matching services to enrich outcomes across projects; and 6) providing training on and facilitating the exchange of methodological, computational, and analytic ideas related to the study of overdose and opioid-related harms. DRM Core Director Dr. Brandon Marshall is an established CDC- and NIH-funded investigator with extensive experience in cohort study design, survey development, and the use of advanced quantitative methods, including simulation approaches, to evaluate non-randomized public health interventions. His leadership will be supplemented by highly trained staff with expertise in epidemiological methods, project management, database development, programming, data visualization, and biostatistics.

项目摘要 尽管干预措施具有公共卫生意义，但重点是类阿片使用障碍和预防过量， 往往缺乏严格的设计和评估。数据和研究方法（DRM）核心 支持COBRE项目负责人和试点调查员克服方法，分析， 传统上阻碍研究项目成功和公共卫生影响的转化挑战。通过 数字版权管理核心将提供定量的专业知识、研究基础设施和技术资源， 加强COBRE项目领导人的工作质量，并改进他们的数据 使用/管理能力。DRM核心服务将包括：1）研究设计的方法学咨询 抽样、匹配、调查开发和数据协调等问题; 2）统计支持， 作为统计模型的使用，模型建立程序，模型规范和处理方法 缺失数据; 3）“仪表板”和其他可视化服务，以生成用户友好的交互式数据 用于信息传播和翻译的输出; 4）提供符合HIPAA的数据管理 系统，将提供多层访问，备份和去识别; 5）提供访问和链接， 现有的和新的全州过量相关数据库，以及记录匹配服务，以丰富 6）提供培训，并促进方法学， 与过量和阿片类药物相关危害研究相关的计算和分析思想。 DRM核心主任布兰登马歇尔博士是一个既定的疾病预防控制中心和国家卫生研究院资助的研究人员与广泛的 在队列研究设计、调查开发和使用先进定量方法方面的经验， 包括模拟方法，以评估非随机公共卫生干预措施。他的领导将是 由在流行病学方法、项目管理、数据库、 开发、编程、数据可视化和生物统计学。