Core C: Translational and Transformative Research

核心 C：转化和变革研究

• 批准号: 10711728
• 负责人: TRACI C GREEN
• 金额: $ 32.22万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711728
• 关键词: Accidents; Address; Adult; Affect; Area; Behavior; Behavior Therapy; Behavioral; Caring; Centers of Research Excellence; Cessation of life; Clinical Sciences; Collaborations; Communication; Communities; Complement; Complex; Conflict (Psychology); Consultations; Data; Data Analyses; Data Collection; Development; Dissemination and Implementation; Educational workshop; Equipment; Event; Evidence based practice; Foundations; Funding; Goals; Growth and Development function; Healthcare Systems; Hospitals; Illicit Drugs; Institution; Interdisciplinary Study; Intervention; Laboratories; Language; Leadership; Mentors; Mentorship; Morbidity - disease rate; Neighborhoods; Opiate Addiction; Opioid; Overdose; Paper; Patients; Peer Review; Pharmaceutical Preparations; Policies; Policy Maker; Prevention; Process; Productivity; Protocols documentation; Publications; Publishing; Qualitative Research; Records; Research; Research Personnel; Research Project Grants; Resources; Rhode Island; Risk; Sampling; Schools; Science; Scientist; Social Sciences; Solid; Technology; Testing; Time; Training; Translating; Translational Research; Translations; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vulnerable Populations; War; Work; Writing; addiction; bench to bedside; career; design; experience; field study; forging; hackathon; innovation; literacy; meetings; member; mortality; novel; opioid epidemic; opioid overdose; opioid use; opioid use disorder; research study; research to practice; simulation; skill acquisition; social; social media; theories; therapy development; tool; translational approach; usability; virtual; web site

PROJECT SUMMARY Nationally, drug overdose is the leading cause of adult accidental death, claiming more lives every year than every armed conflict since the end of the World Wars. Rhode Island is a state devastated by overdose mortality and morbidity. The enormity and urgency of the opioid crisis call for new, translational approaches and faster dissemination of research and promising interventions to transform the care of opioid addiction and overdose, in Rhode Island and nationwide. To maximize the impacts of such scientific findings on the behaviors of patients, clinicians, healthcare systems, and policy makers, the COBRE on Opioids and Overdose needs concerted efforts and key resources to both generate and execute translational research and to create effective study dissemination tools. Local resources to encourage and nurture translational research in the social and behavioral to clinical sciences are limited, and opportunities for skill acquisition, concept development, simulation, and user testing in translational research are not sustained over time. To better optimize the efficacy and reach of the proposed projects, resources to generate and execute translational research and to create effective study dissemination tools are needed. The Translational and Transformative Research (T2) Core aims to continue to provide expert support and technical assistance to junior investigators and affiliated researchers at Rhode Island Hospital, Brown University, and other area hospitals and academic institutions. The long-term goal of the T2 Core is to establish a regional and national hub of translational and transformative resources capable of supporting junior investigators, COBRE projects, and the broader scientific community as they bridge theory to promising intervention and research to practice and policy change for opioid use disorder and overdose. The Core aims are to: 1) Support the execution of high-quality, impactful translational and implementation COBRE-affiliated studies through expert consultation and data collection support on qualitative research, translating theory into intervention, laboratory testing supports, and technology-driven interventions; 2) Develop a culture of excellence and innovation in translational and transformative training and research on opioid use and overdose by hosting annual meetings and contests and quarterly workshops and trainings; and 3) Promote and support implementation and dissemination of COBRE- affiliated research study findings by assisting with data presentation, plans for dissemination, and study communications, including to vulnerable populations and affected communities. Led by experienced and highly productive researchers with extensive mentoring experience, the T2 Core will inspire innovation in translational and transformative research and provide a valuable resource for the COBRE studies.

项目摘要 在全国范围内，药物过量是成年人意外死亡的主要原因，每年夺去的生命超过 自世界大战结束以来的所有武装冲突。罗得岛是一个被药物过量摧毁的州 死亡率和发病率。阿片类药物危机的紧迫性和紧迫性需要新的转化方法 更快地传播研究和有希望的干预措施，以改变阿片类药物成瘾的护理， 在罗得岛和全国范围内都有吸毒过量的人。为了最大限度地发挥这些科学发现对 患者，临床医生，医疗保健系统和政策制定者的行为，阿片类药物和过量的COBRE 需要协调一致的努力和关键资源，以产生和执行转化研究， 有效的研究传播工具。本地资源，以鼓励和培养在 社会和行为的临床科学是有限的，和机会的技能获得，概念 转化研究中的开发、模拟和用户测试不能长期持续。更好地 优化拟议项目的效率和覆盖范围，资源生成和执行翻译 需要进行研究并创建有效的研究传播工具。翻译与变革 研究（T2）核心旨在继续为初级研究人员提供专家支持和技术援助 和附属研究人员在罗得岛医院，布朗大学，和其他地区的医院和学术 机构职能体系T2核心的长期目标是建立一个区域和国家的翻译中心， 能够支持初级研究人员、COBRE项目和更广泛的科学研究的变革性资源 社区，因为他们桥梁理论有前途的干预和研究的实践和政策变化， 阿片类药物使用障碍和过量核心目标是：1）支持执行高质量，有影响力的 通过专家咨询和数据收集转化和实施COBRE-affiliated研究 支持定性研究，将理论转化为干预措施，实验室测试支持，以及 技术驱动的干预措施; 2）在翻译和 通过主办年度会议和竞赛，开展关于类阿片使用和过量的变革性培训和研究， 3）促进和支持COBRE的实施和传播， 通过协助数据介绍、传播计划和研究， 传播，包括向弱势群体和受影响社区传播。由经验丰富、 具有丰富指导经验的高效研究人员，T2核心将激发翻译创新 和变革性的研究，并为COBRE研究提供了宝贵的资源。