Core C: Translational and Transformative Research

项目摘要 在全国范围内，药物过量是成年人意外死亡的主要原因，每年夺去的生命超过 自世界大战结束以来的所有武装冲突。罗得岛是一个被药物过量摧毁的州 死亡率和发病率。阿片类药物流行病的严重性和紧迫性需要新的，翻译 方法，更快地传播研究和有希望的干预措施，以改变阿片类药物的护理 成瘾和过量，在罗得岛和全国。为了最大限度地发挥这些科学发现的影响， 关于患者、临床医生、医疗保健系统和政策制定者的行为， 阿片类药物成瘾和过量需要协调一致的努力和关键资源来产生和执行 转化研究，并创建有效的研究传播工具。当地资源，以鼓励和 培养社会和行为临床科学的转化研究是有限的， 翻译研究中的技能获取、概念开发、模拟和用户测试没有持续下去 随着时间为了更好地优化拟议项目的效率和覆盖面， 执行转化研究，并创建有效的研究传播工具是必要的。平移 和转型（T2）核心旨在为初级调查人员提供专家支持和技术援助 以及布朗大学罗得岛医院和其他地区医院和机构的附属研究人员。 T2核心的长期目标是建立一个翻译和变革的区域和国家中心， 能够支持初级研究人员、COBRE项目和更广泛的科学界的资源， 他们将理论与有希望的干预措施联系起来，将研究与阿片类药物成瘾的实践和政策变化联系起来 还有吸毒过量核心目标是：1）支持执行高质量的翻译和实施 通过专家咨询和数据收集支持，开展与COBRE-affiliated研究有关的定性研究， 将理论转化为干预措施和技术驱动的干预措施; 2）发展卓越的文化， 创新阿片类药物成瘾和过量的转化和变革培训和研究， 举办年度会议和竞赛，以及季度研讨会和培训;以及3）促进和支持 通过协助提供数据，执行和传播COBRE-affiliated研究结果 介绍、传播计划和研究交流。由经验丰富、工作效率高的 T2核心将激发翻译和创新领域的创新， 变革性的研究，并为COBRE研究提供了宝贵的资源。

PROJECT SUMMARY Nationally, drug overdose is the leading cause of adult accidental death, claiming more lives every year than every armed conflict since the end of the World Wars. Rhode Island is a state devastated by overdose mortality and morbidity. The enormity and urgency of the opioid epidemic call for new, translational approaches, and faster dissemination of research and promising interventions to transform the care of opioid addiction and overdose, in Rhode Island and nationwide. To maximize the impacts of such scientific findings on the behaviors of patients, clinicians, healthcare systems, and policy makers, the proposed COBRE on Opioid Addiction and Overdose needs concerted efforts and key resources to both generate and execute translational research, and to create effective study dissemination tools. Local resources to encourage and nurture translational research in the social and behavioral to clinical sciences are limited, and opportunities for skill acquisition, concept development, simulation, and user testing in translational research are not sustained over time. To better optimize the efficacy and reach of the proposed projects, resources to generate and execute translational research, and to create effective study dissemination tools are needed. The Translational and Transformative (T2) Core aims to provide expert support and technical assistance to junior investigators and affiliated researchers at Rhode Island Hospital, Brown University, and other area hospitals and institutions. The long-term goal of the T2 Core is to establish a regional and national hub of translational and transformative resources capable of supporting junior investigators, COBRE projects, and the broader scientific community as they bridge theory to promising intervention, and research to practice and policy change for opioid addiction and overdose. The Core aims are to: 1) Support the execution of high-quality translational and implementation COBRE-affiliated studies through expert consultation and data collection support on qualitative research, translating theory into intervention, and technology-driven interventions; 2) Develop a culture of excellence and innovation in translational and transformative training and research on opioid addiction and overdose by hosting annual meetings and contests, and quarterly workshops and trainings; and 3) Promote and support implementation and dissemination of COBRE-affiliated research study findings, by assisting with data presentation, plans for dissemination, and study communications. Led by experienced and highly productive researchers with extensive mentoring experience, the T2 Core will inspire innovation in translational and transformative research, and provide a valuable resource for the COBRE studies.