Core D: Special Populations

核心 D：特殊人群

• 批准号: 10711729
• 负责人: CURT G BECKWITH
• 金额: $ 28.54万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711729
• 关键词: Address; Applications Grants; Area; Attention; Behavioral Research; Black race; COVID-19 pandemic; Centers of Research Excellence; Clinical; Clinical Research; Color; Communities; Consultations; Data Collection; Drug user; Educational workshop; Environment; Ethics; Failure; Funding; Future; Goals; Harm Reduction; Health; Healthcare; Hospitals; Human Subject Research; Indigenous; Institution; Institutional Review Boards; Mentors; Mission; Names; Opioid; Overdose; Participant; Persons; Pharmaceutical Preparations; Phase; Reproducibility; Research; Research Activity; Research Design; Research Ethics; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Rhode Island; Role; Services; Special Population; Substance Use Disorder; Technology; Training; Translational Research; Trauma; Underserved Population; United States National Institutes of Health; Vulnerable Populations; community engaged research; community engagement; community organizations; empowerment; experience; fentanyl test; health disparity; marginalized community; opioid epidemic; opioid use disorder; overdose death; recruit; skills; test strip; underserved community; vulnerable community

PROJECT SUMMARY The Community Engaged Research Core (CERC) of the COBRE on Opioids and Overdose, formerly the Special Populations Core in Phase 1, promotes research among people who are impacted by opioids and overdose, particularly people who are vulnerable and underserved. The CERC supports the overall mission of the COBRE by building research infrastructure and providing services to early-stage investigators to support the recruitment and retention of vulnerable and underserved individuals as research participants and promotes the importance of community engagement with the goal of developing more robust, rigorous, and competitive research projects. Guided by the conceptual and theoretical framework of Community Engaged and Participatory Research, the CERC focuses on addressing the opioid epidemic by supporting and expanding community-engaged research. The near-term goals of the CERC are to support Project Leaders and pilot- funded investigators in the conduct of community-engaged research related to opioids and overdose. The long- term goals of the CERC are to build a sustainable research infrastructure to support research involving people impacted by opioids and overdose, particularly people from vulnerable and underserved communities, across Rhode Island Hospital and affiliated institutions. The CERC promotes clinical, behavioral, and translational research inclusive of community perspectives through four specific aims. Aim 1) Develop, promote, and support best practices related to community engagement in research on opioids and overdose by a) offering trainings and consultations to COBRE-supported investigators, affiliated researchers, and community partner organizations on the Core’s five Principles of Community Empowered Research; b) maintaining and promoting the established community advisory board to advise COBRE investigators at all stages of research; and c) developing and implementing standards for trauma-informed research for COBRE projects. Aim 2) Promote and support the ethical conduct of research on opioids and overdose by: a) providing regulatory support and consultation services for human subjects research; b) creating project-specific advisory panels comprised of researchers and community stakeholders to provide guidance on study design, implementation, and dissemination activities; and c) providing mentoring in traditional research ethics and the ethics of community- engaged research. Aim 3) Promote research on Harm Reduction (HR) by: a) facilitating HR research presentations/workshops and offering HR trainings to community partners; b) supporting investigators conducting HR research by engaging with HR organizations and people who use drugs; and 3) supporting drug checking research within impacted communities. Aim 4) Promote the role of community engagement in achieving rigor and reproducibility by: 1) mentoring new investigators on integrating community-engaged research into study design, recruitment, data collection, and analysis; and 2) conducting workshops on how community-engaged research can assist in strengthening attention to rigor, replication, and issues of external validity across COBRE research activities.

项目摘要 COBRE阿片类药物和过量社区研究核心（CERC），前身为 第一阶段的特殊人群核心，促进对受阿片类药物影响的人的研究， 过量服用，特别是那些脆弱和得不到充分服务的人。CERC支持以下总体使命： 通过建立研究基础设施和为早期研究人员提供服务， 招募和留住弱势和得不到充分服务的个人作为研究参与者， 社区参与的重要性，以发展更强大，更严格和更有竞争力的目标 研究项目。以社区发展的概念和理论框架为指导， CERC的重点是通过支持和扩大阿片类药物的流行来解决阿片类药物的流行问题。 社区参与的研究。CERC的近期目标是支持项目领导人和试点- 资助调查人员开展与类阿片和过量有关的社区参与研究。很长的- CERC的长期目标是建立一个可持续的研究基础设施，以支持涉及人类的研究 受阿片类药物和过量的影响，特别是来自脆弱和服务不足社区的人， 罗得岛医院及附属机构。CERC促进临床，行为和翻译 研究通过四个具体目标包括社区观点。目标1）开发、推广和 支持与社区参与类阿片和过量研究有关的最佳做法， 为COBRE-supported调查人员、附属研究人员和社区合作伙伴提供培训和咨询 （B）维护和促进社区赋权研究的核心五项原则; 设立社区咨询委员会，在研究的各个阶段为COBRE研究人员提供咨询;以及c） 为COBRE项目制定和实施创伤知情研究标准。目标2）促进 并通过以下方式支持阿片类药物和过量研究的道德行为：a）提供监管支持， 为人类受试者研究提供咨询服务; B）创建特定项目咨询小组， 研究人员和社区利益相关者就研究设计、实施和 传播活动;以及c）提供传统研究伦理和社区伦理方面的指导， 从事研究。目标3）通过以下方式促进减少伤害（HR）的研究：a）促进HR研究 向社区合作伙伴提供演讲/研讨会和人力资源培训; B）支持调查人员 通过与人力资源组织和吸毒者接触进行人力资源研究;以及3）支持药物 检查受影响社区内的研究。目标4）促进社区参与的作用， 通过以下方式实现严谨性和可重复性：1）指导新的研究人员将社区参与 对研究设计、招募、数据收集和分析进行研究; 2）举办研讨会，讨论如何 社区参与的研究可以帮助加强对严格性，复制和外部问题的关注。 COBRE研究活动的有效性。