Bioinformatics

项目摘要：生物信息学核心 视觉科学，就像生物学中的许多领域一样，正从技术中受益匪浅 使收集关于基因、蛋白质、脂质和 眼睛和大脑的完整组织中的细胞结构。同样，功能成像的进展 使得收集视网膜和大脑中神经元活动的信息变得更容易 他们是在对视觉图像做出反应。虽然伯克利分校的科学家在 收集大数据集，许多调查人员和他们的实验室缺乏知识、资源和 组织、处理和分析数据以显示有意义的结果的时间。通过输入 新视觉科学教员在生物信息学方面拥有丰富的专业知识，并提供 一大批非常精明的年轻专业数据科学家组成的本地劳动力池，我们决定 建立一个新的生物信息学核心，为视觉科学提供急需的服务 教职员工。核心的目标是1)建立基于云的管道，用于预处理、存储 和高通量单细胞转录和成像数据的检索，2)开发和 维护生物信息管道，以支持对新的和公开可用的信息进行下游分析 提供生物信息学方法方面的咨询和培训服务。

Project Summary Bioinformatics Core Vision science, like many fields in biology, is benefitting tremendously from technological advances that make it possible to collect huge amounts of data about genes, proteins, lipids, and cellular structures in intact tissues of the eye and brain. Likewise, advances in functional imaging are making it easier to collect information about activity of neurons in the retina and brain as they are responding to visual images. While Berkeley scientists have tremendous expertise in collecting “big data” sets, many investigators and their labs lack the knowledge, resources, and time to organize, process, and analyze the data to reveal meaningful results. With the entry of a new Vision Science faculty member with great expertise in Bioinformatics and the availability of a great local labor pool of highly astute young expert Data Scientists, we have decided to establish a new Bioinformatics Core that will provide sorely needed to services to Vision Science faculty. The Aims of the Core are 1) to establish cloud-based pipelines for preprocessing, storage and retrieval of high-throughput single-cell transcriptomics and imaging data, 2) develop and maintain bioinformatic pipelines to support downstream analysis of new and publicly available datasets, and 3) provide advisory and training services on bioinformatic methods.