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Admittance to measure cardiac mechanics in mice

测量小鼠心脏力学的准入

基本信息

批准号：
7268052
负责人：
MARC David FELDMAN
金额：
$ 14.26万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7268052
关键词：
Acute Animals Applications Grants Blood Cardiac Cardiomyopathies Catheters Compatible Complex Computer Simulation Congestive Heart Failure Conscious Data Devices EFRAC Elements Equation Feedback Frequencies Generations Genes Goals Gold Heart Heart Rate Imaging technology Individual Inferior Vena Cava Occlusion Label Left Magnetic Resonance Imaging Measurable Measurement Measures Mechanics Methods Mind Modeling Morphologic artifacts Mus Muscle Myocardial Myocardium Operative Surgical Procedures Patients Pharmaceutical Preparations Phase Phenotype Physics Physiologic intraventricular pressure Physiological Plague Property Range Rate Research Personnel Sampling Signal Transduction Solutions Standards of Weights and Measures Stroke Volume Structure Study models Surface Technology Telemetry Testing Thick Time Two-Dimensional Echocardiography Ultrasonics United States Food and Drug Administration Ventricular Ventricular Function Work Working stroke analog base data acquisition desire digital electric field hemodynamics improved in vivo instrument miniaturize pressure programs response size trend voltage

项目摘要

DESCRIPTION (provided by applicant): Genetically altered mice provide a mechanism to define the in vivo phenotype of individual genes. This is especially relevant to genes implicated in producing myocardial diseases leading to congestive heart failure. The classic method to assess the hemodynamic phenotype in larger animals is through left ventricular (LV) pressure-volume (PV) analysis. However, determining absolute and instantaneous volume in the murine LV has been plagued by its small size and rapid heart rate. Conductance measurements offer an attractive solution to this problem by generating an instantaneous LV volume signal compatible with any myocardial size or heart rate. Unfortunately, the first generation conductance instrument generates an instantaneous conductance (volume) signal composed of blood and myocardium even at a single lower frequency. Only the blood component is desired for PV analysis. A mechanism to overcome this limitation is proposed by measuring admittance (complex conductance). Admittance is composed of both the magnitude of LV blood and myocardial conductance, and the phase angle of myocardial conductance. Traditional single frequency conductance measures only the magnitude of the conductance signal, which includes both the blood and myocardial components. Because measurable phase angle is unique to muscle, admittance offers a better method to determine and remove the instantaneous myocardial contribution to the combined LV conductance (volume) signal. The GOAL of this grant application is to develop, calibrate, and validate an INSTRUMENT to measure both the magnitude and the phase angle of the admittance signal in real time. To accomplish this goal, we will - 1) Develop both analog hardware and digital data acquisition Admittance Instruments, 2) Develop a more accurate method to derive LV volume from admittance measurements using FEM, and 3) Demonstrate that an Admittance Instrument is superior to traditional single frequency with MRI.

描述（由申请人提供）：转基因小鼠提供了一种机制来定义单个基因的体内表型。这与产生导致充血性心力衰竭的心肌疾病的基因尤其相关。评估大型动物血流动力学表型的经典方法是通过左心室（LV）压力-容积（PV）分析。然而，小鼠左室体积小、心率快，一直困扰着其绝对容积和瞬时容积的测定。电导测量通过产生与任何心肌大小或心率兼容的瞬时左室容积信号，为这个问题提供了一个有吸引力的解决方案。不幸的是，第一代电导仪即使在一个较低的频率下也会产生由血液和心肌组成的瞬时电导（体积）信号。PV分析只需要血液成分。通过测量导纳（复电导），提出了克服这一限制的机制。导纳由左室血和心肌电导的幅度以及心肌电导的相角组成。传统的单频电导仅测量电导信号的幅度，其中包括血液和心肌成分。由于可测量的相位角是肌肉所特有的，导纳提供了一种更好的方法来确定和消除心肌对组合左室电导（体积）信号的瞬时贡献。本拨款申请的目标是开发、校准和验证一台仪器，以实时测量导纳信号的幅度和相位角。为了实现这一目标，我们将- 1)开发模拟硬件和数字数据采集导纳仪器，2)开发一种更准确的方法，使用FEM从导纳测量中获得左室体积，以及3)证明导纳仪器优于传统的单频MRI。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validation of a new micro-manometer pressure sensor for cardiovascular measurements in mice.

DOI：
10.2345/0899-8205-44.1.75
发表时间：
2010-01-01
期刊：
Biomedical instrumentation & technology
影响因子：
0
作者：
Trevino, Rodolfo J;Jones, Douglas L;Feldman, Marc D
通讯作者：
Feldman, Marc D

A bio-telemetric device for measurement of left ventricular pressure-volume loops using the admittance technique in conscious, ambulatory rats.

DOI：
10.1088/0967-3334/32/6/007
发表时间：
2011-06
期刊：
Physiological measurement
影响因子：
3.2
作者：
Raghavan K;Feldman MD;Porterfield JE;Larson ER;Jenkins JT;Escobedo D;Pearce JA;Valvano JW
通讯作者：
Valvano JW

Accuracy considerations in catheter based estimation of left ventricular volume.

基于导管的左心室容量估计的准确性考虑因素。