METEOR-Data Synthesis and Transfer (METEOR-DST)

Meteor-DST摘要 流星数据合成和传输(DST)共享资源为以下方面提供专业知识和系统 合成流星中所有数据源的数据，并能够传输合成的 将数据存储到更大的NCI数据生态系统和存储库中。DST解决了聚合多个数据的关键问题 组学数据、成像、放射治疗和临床数据，并使这些数据能够在用户友好的 举止。随着上述目标的圆满完成，我们将确保收集和管理 以符合公平和信任原则的方式进行患者派生数据的处理。 我们将增强Cielo，这是一个HIPAA安全的健康研究开放科学平台，以支持工作流 以及Robin所需的数据类型。Cielo允许不同的最终用户共享、发现和适应/采用 “捆绑”的健康信息，如多尺度、纵向定义的表型。这将作为一种 全面的端到端解决方案，可实现以数据为中心的跨罗宾研究协作 涉及多个罗宾中心和更远的地方。我们将添加：(1)从多个 资源，然后通过为患者、组织和组织创建一致的标识符来协调和集成数据 示例；(2)与RedCap、XNAT等多个内部平台和系统的基于API的接口 Openspecimen和机构EHR仓库；(3)增加对外部数据导出到其他数据的支持 NCI数据生态系统中的存储库。 我们将部署和增强XNAT，以支持Robin中的成像和放射治疗数据，并与 谢洛。XNAT是一个基于Web的软件平台，旨在促进共同管理和提高工作效率 用于成像和关联数据的任务。它由一个图像存储库组成，用于存储原始图像和后处理图像 图像、用于存储元数据和非成像测量的数据库、以及用于访问、 查询、可视化和浏览数据。我们将增强XNAT以存储放射治疗DICOM格式(RT 结构集、RT剂量、分割对象)，并在XNAT的网络中可视化放射治疗注释- 基于图像查看器。我们将通过XNAT丰富的REST API将XNAT与Cielo完全集成。 我们将确保以一致的方式收集和管理患者派生的数据 秉持公平和信任的原则。所有流星数据(eCRF、生物样品可用性和特性)将 使用REST接口聚合到Cielo和XNAT中，并从我们的研究中自动提取数据 数据核心，以及手动上传功能。流星BLST团队基因组学的处理结果， 转录组学、蛋白质组学和代谢组学分析，包括整体、单细胞和空间实验， 将被上传到Cielo。

METEOR-DST SUMMARY The METEOR Data Synthesis and Transfer (DST) shared resource provides expertise and systems for synthesizing data from across all data sources in METEOR and enabling the ability to transfer the synthesized data into the larger NCI Data ecosystem and repositories. DST addresses the critical issue of aggregating multi- omics data, imaging, radiotherapy, and clinical data as well as enabling these data to be shared in a user-friendly manner. With the successful completion of the aims outlined, we will ensure that the collection and management of patient-derived data is performed in a manner consistent with FAIR and TRUST principles. We will augment CIELO, a HIPAA-secure open science platform for health research, to support the workflows and data types needed for ROBIN. CIELO allows diverse end-users to share, discover, and adapt/adopt “bundles” of health information, such as multi-scale, longitudinally defined phenotypes. This will serve as a comprehensive and “end-to-end” solution for enabling Trans-ROBIN data-centric research collaborations involving multiple ROBIN Centers and beyond. We will add: (1) the capability to ingest the data from multiple sources and then harmonize and integrate the data by creating consistent identifiers for patients, tissues, and sample; (2) API-based interfaces with a number of internal platforms and systems such as REDCap, XNAT OpenSpecimen, and institutional EHR warehouse; (3) addition of support for external data export to other data repositories in the NCI data ecosystem. We will deploy and enhance XNAT to support imaging and radiation therapy data in ROBIN and integrate with CIELO. XNAT is a web-based software platform designed to facilitate common management and productivity tasks for imaging and associated data. It consists of an image repository to store raw and post-processed images, a database to store metadata and non-imaging measures, and user interface tools for accessing, querying, visualizing, and exploring data. We will enhance XNAT to store radiation therapy DICOM formats (RT Structure Set, RT Dose, Segmentation Objects) and to visualize radiation therapy annotations in XNAT’s web- based imaging viewer. We will fully integrate XNAT with CIELO via XNAT’s extensive REST API. We will ensure that the collection and management of patient-derived data is performed in a manner consistent with FAIR and TRUST principles. All METEOR data (eCRFs, biospecimen availability & characterization) will be aggregated into CIELO and XNAT, using REST interfaces, and automated data extraction from our Research Data Core, as well as manual upload capabilities. Processed results of the METEOR-BLST team’s genomics, transcriptomics, proteomics, and metabolomics analyses, including bulk, single-cell, and spatial experiments, will be uploaded into CIELO.