Leveraging Ethnic Anotia-microtia Disparities for Discovery (LEADD) Study
Leveraging Ethnic Anotia-microtia Disparities for Discovery (LEADD) Study
批准号:
10715649
负责人:
Jeremy Schraw
金额:
$79.37万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-07-31 至 2028-02-29
关键词:
AddressAdverse eventAffectAmericanAmerindianAnxietyArchivesAwarenessBirthBloodCaliforniaCharacteristicsChildClinical ManagementConfidence IntervalsCongenital AbnormalityDataDiagnosisDietDiseaseDisparityEarEducationEnvironmentEnvironmental Risk FactorEpidemiologyEthnic OriginEthnic PopulationEtiologyExternal EarFacial nerve structureFutureGenesGeneticGenetic VariationGenomeGenotypeHealth Care CostsHearingHeritabilityHispanicHispanic PopulationsHuman GeneticsIndividualInfantInvestigationLatinx populationLife Cycle StagesLive BirthMachine LearningMapsMaternal ExposureMaternal HealthMental DepressionMethodsMonitorMothersNeighborhoodsNeonatalNot Hispanic or LatinoOperative Surgical ProceduresParticipantPatient Self-ReportPediatric ResearchPharmaceutical PreparationsPopulationPopulation HeterogeneityPrevalencePreventionPrimary PreventionReconstructive Surgical ProceduresRegistriesRiskRisk EstimateRisk FactorsRoleSocioeconomic FactorsSocioeconomic StatusSpottingsSyndromeTechniquesTexasTimeUpdateValidationWorkadverse outcomebiobankbioinformatics toolbiological specimen archivescase controlcausal variantchildhood hearing losscongenital anomalyethnic differenceethnic disparityforestgenetic variantgenome sequencinggenome wide association studygenome-widehealth disparityhearing impairmenthigh risk populationinsightmembermicrotiamulti-ethnicmultidisciplinarynon-geneticnovelpeerpopulation basedprogramsresidencesegregationsocialsociodemographic factorssociodemographicswhole genome
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Anotia/microtia is a birth defect characterized by an absent or hypoplastic external ear; it is estimated that
>80,000 Americans are living with this condition, which causes significant hearing loss in >75% of affected
individuals. This study will identify social/environmental and genetic drivers of anotia/microtia, with an
emphasis on addressing health disparities for Hispanic/Latinx populations. Notably, the birth prevalence of
anotia/microtia is increased in Hispanic relative to non-Hispanic white populations, but Hispanic infants are less
likely to be diagnosed with an anotia/microtia syndrome than their non-Hispanic white peers. This study will
use a three-part approach. First, by leveraging data on >10 million live births and >3,500 cases with
anotia/microtia from population-based birth defects registries in California and Texas, it will evaluate the extent
to which sociodemographic factors explain differences in the birth prevalence of anotia/microtia syndromes
between Hispanic and non-Hispanic populations. Second, using an ancestry-aware genome-wide association
method (Tractor), archived biospecimens from the California Biobank Program and National Birth Defects
Prevention Study, and publicly available whole-genome sequencing data from the Gabriella Miller Kids First
Pediatric Research Initiative, it will identify genetic variants associated with anotia/microtia in Hispanic and
non-Hispanic individuals. Next, it will apply a rigorous machine learning technique to data from the National
Birth Defects Prevention Study (N=699 cases with anotia/microtia and >10,000 controls without birth defects)
to identify maternal exposures associated with anotia/microtia in Hispanic and non-Hispanic populations.
Finally, it will perform an integrative assessment of the role of sociodemographic, genetic, and maternal factors
in determining risk for anotia/microtia. In accomplishing these objectives, the study will: identify drivers of
disparities in anotia/microtia among Hispanic populations; shed light on the etiology of anotia/microtia in
diverse populations by characterizing genetic variants associated with this disease, which will be targets for
future investigation; and identify potentially modifiable maternal exposures that could be used to facilitate
prevention.
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