Next-Generation Whole-Body MRI for Detection and Assessment of Therapy Response in Bone Lesions
用于检测和评估骨病变治疗反应的新一代全身 MRI
基本信息
- 批准号:10716642
- 负责人:
- 金额:$ 54.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AbdomenAddressAnatomyBone MarrowBone Marrow TransplantationBone marrow biopsyChestClinicalClinical TrialsDetectionDevelopmentDiagnosisDiagnosticDiffusionDiffusion Magnetic Resonance ImagingDiseaseFatty acid glycerol estersGenerationsGoalsImageImage EnhancementImaging TechniquesImaging technologyIndustry StandardLesionLimb structureLiquid substanceLocalized LesionLocationMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of prostateMapsMarrowMeasurementMeasuresMetastatic Neoplasm to the BoneMethodsMorphologic artifactsMotionMultiple MyelomaMusculoskeletalNeoadjuvant TherapyNon-MalignantOutcomePET/CT scanPainParalysedPathological fracturePathologyPatient CarePatientsPelvisPerformancePerfusionPrognosisPrognostic MarkerProgression-Free SurvivalsProtocols documentationQuality of lifeRecommendationReference StandardsRenal carcinomaResolutionRoentgen RaysScanningSignal TransductionSkeletonSolid NeoplasmTestingTimeVertebral columnVisualizationbonebone imagingbone lossclinical practiceclinical translationclinically relevantcontrast enhancedcostcost effectiveexperiencefluorodeoxyglucose positron emission tomographyimaging biomarkerimaging detectionimaging modalityimprovedin vivoinnovationmalignant breast neoplasmneoplastic cellnext generationnovelpediatric patientsspinal cord compressionstandard of caretreatment responsetumor
项目摘要
Project Summary
Bone lesions from solid tumors such as breast, prostate, or kidney cancers, tumors originating in the bone
marrow such as multiple myeloma (MM), or other non-malignant musculoskeletal pathologies can occur
anywhere in the skeleton. These bone lesions cause pain and spinal cord compressions, leading to pathologic
fractures and paralysis, thereby diminishing the patient's quality of life. Current therapies rely on diagnosing
these bone lesions by whole-body X-ray or bone scans, which only identify them at advanced stages. While
whole-body magnetic resonance imaging (WBMRI) is recommended for pretreatment assessment (e.g., in
MM), MRI is often limited to spine and pelvic regions in practice to minimize patient discomfort, compromised
image quality from geometric distortion, and high costs due to prolonged acquisition times. To address this
unmet clinical need, we developed a novel WBMRI technique: `Dual-Echo T2-weighted acquisition for
Enhanced Conspicuity of Tumors' (DETECT), for improved lesion visualization by simultaneously separating
the confounding signals of fat and fluid. Compared to WBMRI with diffusion-weighted imaging (DWI), single-
shot DETECT increased lesion detection (>40%) in considerably shorter scan times (<10 min) and without
image distortions. This method also improved robustness to motion in the thoracic and abdomen regions,
however, it suffers from image blurring due to T2-decay particularly in spine and extremities, limiting the
diagnostic performance. In the current proposal, we will address these limitations by developing the next-
generation WBMRI-DETECT using an efficient combination of single-shot and multi-shot acquisitions. DETECT
also generates fat signal for quantitative fat fraction (FF) maps that can be used as a prognostic biomarker in
MM, since tumor cells replace fat, a major constituent of bone marrow. This method also led us to develop a
DETECT-based DWI technique for accurate measurement of apparent diffusion coefficient (ADC). The specific
aims are: 1) To develop an integrated WBMRI using single-shot and multi-shot DETECT, along with
quantitative FF maps; 2) To develop a DETECT-based DWI with accurate ADC measurements; and 3) To
evaluate the integrated WBMRI, including DETECT-DWI and contrast-enhanced perfusion, for efficient bone
lesion detection and therapy response assessment. We will use bone lesions in MM as the proof-of-concept
disease to achieve these project goals. The successful outcome of this project will be an efficient WBMRI
protocol with accurate FF and ADC measures as imaging biomarkers, validated in detection and measuring
therapy response in MM patients. This WBMRI in combination with contrast-enhanced MRI including perfusion,
will be an excellent cost-effective and practical approach (<45 minutes of table time) for widespread use in
clinical practices across the world. This will benefit MM patients and patients suffering from other bone lesions,
including pediatric patients during long follow-ups, without the drawbacks of PET/CT. This will provide relevant
clinical information for treatment decisions to positively impact patients' quality of life and overall survival.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ananth Jayaseelan Madhuranthakam其他文献
Ananth Jayaseelan Madhuranthakam的其他文献
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{{ truncateString('Ananth Jayaseelan Madhuranthakam', 18)}}的其他基金
Quantitative Non-Contrast Perfusion using Arterial Spin Labeling for Assessment of Cancer Therapy Response
使用动脉旋转标记进行定量非对比灌注评估癌症治疗反应
- 批准号:
10475022 - 财政年份:2017
- 资助金额:
$ 54.82万 - 项目类别:
Quantitative Non-Contrast Perfusion using Arterial Spin Labeling for Assessment of Cancer Therapy Response
使用动脉旋转标记进行定量非对比灌注评估癌症治疗反应
- 批准号:
9765190 - 财政年份:2017
- 资助金额:
$ 54.82万 - 项目类别:
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