Cochlear micromechanical mechanisms underlying psychoacoustic phenomena
心理声学现象背后的耳蜗微机械机制
基本信息
- 批准号:10715565
- 负责人:
- 金额:$ 58.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-16 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:Acoustic NerveAction PotentialsAffectApicalBasilar MembraneClinicCochleaComplexDetectionDiagnosisFrequenciesGerbilsHearing problemHumanInner Hair CellsKnowledgeLocationMeasurementMeasuresMechanicsMusicNerve FibersNoiseOuter Hair CellsPatientsPitch PerceptionProceduresPsychoacousticsPsychophysicsRoleScientistSeriesSpeechStimulusTestingcell motilityexperimental studyfascinatehearing impairmentimprovedneuralnovelresponsesoundvibration
项目摘要
Project Summary/Abstract
Although the pitch of missing fundamentals has been studied for more than a century, and psychophysical
tuning curves and gap detection have been used as non-invasive tests for diagnosing auditory disorders, the
cochlear mechanical mechanisms underlying these psychoacoustic phenomena remain unclear. This project
aims to study the cochlear micromechanical mechanisms contributing to the pitch of missing fundamentals,
psychophysical tuning curves, and gap detection by measuring the reticular lamina (RL) vibration from apical
ends of the outer hair cells (OHCs) and the auditory nerve potential in living gerbil cochleae. Our overarching
hypothesis is that the mechanical missing fundamental is generated by OHCs and can be detected at the
cochlear locations tuned to stimulus frequencies. Masker-induced suppression and enhancement and
poststimulation oscillation of the RL vibration contribute to the neural tuning curves and gap detection. This
hypothesis will be tested by conducting the following experiments. Experiment One will measure the cochlea-
generated fundamentals in the RL vibration and auditory nerve potential and observe the effect of a noise
masker on the RL and auditory nerve fundamentals. The unmaskable RL and auditory nerve fundamentals will
indicate that the cochlea can generate the fundamental, and this cochlea-generated fundamental can be
detected at cochlear locations tuned to stimulus frequencies. Experiment Two will measure the RL mechanical
tuning curves, the auditory nerve simultaneous and forward masking tuning curves, and the masker-induced
changes in the RL probe response. The results from this experiment will determine whether the simultaneous
or forward masking tuning curve can accurately reflect the RL mechanical tuning curve and whether the
masker-induced changes in the RL probe response contribute to the cochlear compound action potential
(CAP) tuning curves. Experiment Three will measure the RL poststimulation vibration and compare the
duration of this persistent vibration to the gap detection threshold. The expected result from this experiment will
indicate that the RL poststimulation can excite the inner hair cells and auditory nerve fibers during the gap
period, which affects the auditory nerve response to the stimulus after the gap. Thus, the results from this
study will reveal cochlear micromechanical mechanisms underlying the pitch of missing fundamentals,
psychoacoustic tuning curves, and gap detection. The knowledge gained from this project can benefit patients
by optimizing procedures and improving the interpretation of psychoacoustic tests in clinics.
项目总结/文摘
项目成果
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{{ truncateString('TIANYING REN', 18)}}的其他基金
Studies of cochlear mechanics: otoacoustic emissions
耳蜗力学研究:耳声发射
- 批准号:
6869513 - 财政年份:2004
- 资助金额:
$ 58.05万 - 项目类别:
Studies of cochlear mechanics: otoacoustic emissions
耳蜗力学研究:耳声发射
- 批准号:
6768962 - 财政年份:2004
- 资助金额:
$ 58.05万 - 项目类别:
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