Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive Decline
认知衰老、阿尔茨海默病和癌症相关的认知能力下降
基本信息
- 批准号:10715609
- 负责人:
- 金额:$ 31.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerAmyloid beta-42Assessment toolAstrocytesBasic ScienceBiological AssayBiological MarkersBreast Cancer survivorCancer ControlCancer SurvivorClinicalClinical ResearchClinical TrialsCognitiveCognitive agingCollaborationsDataDementiaDiagnosticDiseaseEnsureEnvironmental Risk FactorEtiologyFundingFutureGeneticGlial Fibrillary Acidic ProteinGoalsHeterogeneityHomeImpaired cognitionIndianaIndividualInstitutionLaboratoriesLeftLightLongevityMalignant NeoplasmsMeasuresMonitorMorbidity - disease rateOlder PopulationParticipantPathologicPathologyPharmacodynamicsPlasmaPopulationPreventionQuality ControlQuality of lifeReportingResearchResearch PersonnelRisk FactorsSamplingSocial isolationSpecific qualifier valueSpecimenSurvivorsSystemTestingTimeUniversitiesValidationaging brainamyloid pathologyblood-based biomarkercancer-related cognitive impairmentcognitive testingcostdata de-identificationdata sharing networksdisorder riskfollow-upgenome wide association studyhealth disparityimprovedinsightmortalitymultiplex assayneurofilamentneuroprotectionnovelnovel markernovel therapeuticsparent grantpatient screeningpredictive markerrepositoryresponserisk predictionscreeningtau-1therapeutic target
项目摘要
The goal of the parent grant is to study heterogeneity in cognitive aging and relationships between cancer-related
cognitive decline (CRCD) and Alzheimer’s disease related dementias (ADRD). The broad research question is
whether CRCD is the result of damage due to the cancer and its therapies that accelerate an underlying early
ADRD or damage to similar systems as are involved in ADRD. To address this question we are testing ADRD
plasma biomarkers and using the results to test the overarching hypothesis that breast cancer survivors ages
60+ with CRCD will have more plasma ADRD-pathology biomarker abnormalities than survivors with no
cognitive abnormalities or contemporaneously assessed non-cancer controls. The originally proposed
ADRD biomarkers in the parent grant were Aβ1-42, p-tau and neurofilament light chain [NfL]. These assays were
planned in a collaborating federal laboratory where the director has left the institution. In the interim, Dr. Jeff
Dage, a leading expert in plasma ADRD biomarkers, joined Indiana University (home of MPI Saykin) and the
NIA National Centralized Repository for Alzheimer’s and Related Dementias (NCRAD). During the timeframe of
this project there have also been significant new breakthroughs in the field of blood-based biomarkers for AD.
Measures of Aβ42 and Aβ40 (reported as the 42/40 ratio), P-tau and neurofilament light chain (NfL) are now
being used in clinical trials to screen for patients with AD pathology and monitor pharmacodynamic responses
to new drugs. Additionally, a marker of reactive astrocytes, GFAP, has been shown to be elevated in response
to amyloid pathology in the earliest stages of AD. These breakthroughs have been possible due to advances in
the precision of the plasma biomarker assays, although this has also been accompanied by increased costs
since the time of parent grant submission. With these rapid changes in the field, cost escalations and the
implementation of the NIA NCRAD laboratory, this supplement will: 1) take advantage of the opportunity to move
biomarker testing to the NCRAD laboratory, 2) use the supplemental funds to modify our assays to match the
most advanced biomarkers in the field (Aβ1-42, Aβ1-40, P-tau181, NfL, and GFAP [new markers bolded]), and
3) expand the number of longitudinal samples that can be tested from two time points (n=617 samples) to a
baseline sample and two longitudinal follow-up time points (n=817 samples). Responding to changes in the field
that were not anticipated at the time of our parent grant submission will allow us to expand the parent grant aims
to address new research questions in a robust, up-to-date manner with more sensitive assays, including use of
prespecified cutoffs being established for P-tau181 in the NCRAD lab and comparison of the cancer survivor
and control results to NCRAD standards. Additionally, because TLC participants were cognitively normal at
baseline, adding testing of more longitudinal specimens will allow us to better understand the time course of any
ADRD biomarker changes. The parent grant is now at the start of Year 3 (5/22-4/23), when all assays were
planned, so the timing is ideal to use multiplex assays in the NCRAD to test all available specimens in one batch
to ensure laboratory quality control. These results will provide an outstanding future resource for data sharing.
父母资助的目的是研究认知衰老的异质性和癌症相关
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care.
- DOI:10.1038/s41571-021-00580-3
- 发表时间:2022-03
- 期刊:
- 影响因子:78.8
- 作者:Carroll, Judith E.;Bower, Julienne E.;Ganz, Patricia A.
- 通讯作者:Ganz, Patricia A.
Daily functioning in glioma survivors: associations with cognitive function, psychological factors and quality of life.
- DOI:10.2217/cns-2022-0002
- 发表时间:2022-06-01
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Validating the PROMIS cognitive function short form in cancer survivors.
验证癌症幸存者的 PROMIS 认知功能简表。
- DOI:10.1007/s10549-023-06968-2
- 发表时间:2023
- 期刊:
- 影响因子:3.8
- 作者:Henneghan,AshleyM;VanDyk,Kathleen;Zhou,Xingtao;Moore,RaeanneC;Root,JamesC;Ahles,TimA;Nakamura,ZevM;Mandeblatt,Jeanne;Ganz,PatriciaA
- 通讯作者:Ganz,PatriciaA
Editorial: How Will Aducanumab Approval Impact AD Research?
- DOI:10.14283/jpad.2021.46
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Weiner MW;Aisen PS;Beckett LA;Green RC;Jagust W;Morris JC;Okonkwo O;Perrin RJ;Petersen RC;Rivera Mindt M;Saykin AJ;Shaw LM;Toga AW;Trojanowski JQ
- 通讯作者:Trojanowski JQ
Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE.
- DOI:10.1016/j.nbd.2022.105915
- 发表时间:2022-12
- 期刊:
- 影响因子:6.1
- 作者:Ng, Christi Anne S.;Biran, Lucas P.;Galvano, Elena;Mandelblatt, Jeanne;Vicini, Stefano;Rebeck, G. William
- 通讯作者:Rebeck, G. William
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Jeanne Mandelblatt其他文献
Jeanne Mandelblatt的其他文献
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{{ truncateString('Jeanne Mandelblatt', 18)}}的其他基金
Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and Aging
健康的社会决定因素作为细胞衰老的传导者:减少癌症和衰老交叉点的生存差异的新的多层次范式
- 批准号:
10736380 - 财政年份:2023
- 资助金额:
$ 31.37万 - 项目类别:
A Simulation Modeling Study to Support Personalized Breast Cancer Prevention and Early Detection in High-Risk Women
支持高危女性个性化乳腺癌预防和早期检测的模拟模型研究
- 批准号:
10371141 - 财政年份:2021
- 资助金额:
$ 31.37万 - 项目类别:
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive Decline
认知衰老、阿尔茨海默病和癌症相关的认知能力下降
- 批准号:
10617392 - 财政年份:2020
- 资助金额:
$ 31.37万 - 项目类别:
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive Decline
认知衰老、阿尔茨海默病和癌症相关的认知能力下降
- 批准号:
10408070 - 财政年份:2020
- 资助金额:
$ 31.37万 - 项目类别:
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive Decline
认知衰老、阿尔茨海默病和癌症相关的认知能力下降
- 批准号:
10225649 - 财政年份:2020
- 资助金额:
$ 31.37万 - 项目类别:
Cognitive Aging, Alzheimers disease, and Cancer-related Cognitive Decline
认知衰老、阿尔茨海默病和癌症相关的认知能力下降
- 批准号:
10028895 - 财政年份:2020
- 资助金额:
$ 31.37万 - 项目类别:
Bio-behavioral Research At The Intersection of Cancer and Aging
癌症与衰老交叉点的生物行为研究
- 批准号:
9978577 - 财政年份:2015
- 资助金额:
$ 31.37万 - 项目类别:
Bio-behavioral Research At The Intersection of Cancer and Aging
癌症与衰老交叉点的生物行为研究
- 批准号:
8952028 - 财政年份:2015
- 资助金额:
$ 31.37万 - 项目类别:
Bio-behavioral Research At The Intersection of Cancer and Aging
癌症与衰老交叉点的生物行为研究
- 批准号:
10224107 - 财政年份:2015
- 资助金额:
$ 31.37万 - 项目类别:
Bio-behavioral Research At The Intersection of Cancer and Aging
癌症与衰老交叉点的生物行为研究
- 批准号:
9117500 - 财政年份:2015
- 资助金额:
$ 31.37万 - 项目类别:
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