Animal Models and In Vivo Imaging Core

动物模型和体内成像核心

• 批准号: 10714516
• 负责人: Biju Blavady Thomas
• 金额: $ 19.17万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714516
• 关键词: Acceleration; Address; Animal Disease Models; Animal Model; Basic Science; Center Core Grants; Consultations; Coupled; Development; Equipment; Evaluation; Experimental Animal Model; Eye diseases; Genotype; Harvest; Image; Imaging Techniques; Individual; Molecular; Operative Surgical Procedures; Process; Qualifying; Research; Research Personnel; Resources; Sampling; Signs and Symptoms; Structure; Technical Expertise; Technology; Testing; Therapeutic; Tissues; Training; Translations; Vision; Vision research; cost; in vivo; in vivo imaging; instrument; instrumentation; investigator training; novel diagnostics; novel therapeutic intervention; ocular imaging; operation; vision science

PROJECT SUMMARY: ANIMAL MODELS AND IN VIVO IMAGING CORE The Animal Models and In Vivo Imaging Core will meet the needs of participating investigators for using animal models of ocular diseases to conduct basic and translational vision research. The Core will provide access to advanced technologies and highly qualified technical support for generating and performing in vivo ocular imaging of animal models. The availability of animal models coupled with comprehensive in vivo tissue structure and function assessment will greatly accelerate study of molecular and cellular mechanisms underlying ocular disease processes, and facilitate translation of basic science findings for diagnostic and therapeutic applications. The specific aims are to provide instrumentation and technical expertise for: 1) generating and maintaining animal models of ocular diseases, performing surgical procedures, obtaining samples for genotyping, and harvesting ocular tissues; 2) enabling investigators to use various in vivo ocular imaging and visual function testing technologies; 3) training investigators and research staff on the utility and operation of ocular imaging and function testing equipment; and 4) providing consultation on the appropriate animal models, surgical and imaging procedures, addressing the research needs of participating investigators. .

项目概要：动物模型和体内成像核心 动物模型和体内成像核心将满足参与研究者使用动物模型的需求 眼科疾病的模型进行基础和翻译的视觉研究。核心将提供访问 先进的技术和高素质的技术支持，用于生成和执行体内眼 动物模型的成像。动物模型的可用性加上全面的体内组织 结构和功能评估将大大加速分子和细胞机制的研究 潜在的眼部疾病过程，并促进基础科学发现的诊断和 治疗应用。具体目标是为以下方面提供仪器和技术专门知识： 产生和维持眼部疾病的动物模型，进行外科手术，获得 用于基因分型的样品和收获眼组织; 2）使研究者能够使用各种体内眼组织， 成像和视觉功能测试技术; 3）培训研究人员和研究人员的效用， 操作眼部成像和功能测试设备;以及4）提供适当的咨询 动物模型、手术和成像程序，满足参与研究者的研究需求。 .