Cell & Tissue Imaging and Data Science Core

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PROJECT SUMMARY: CELL & TISSUE IMAGING AND DATA SCIENCE CORE The Cell & Tissue Imaging and Data Science Core will enhance the activities and accomplishments of ongoing research projects by providing histology services, access to a range of advanced imaging equipment, and technical expertise for image analysis and implementation of artificial intelligence (AI) approaches. It will provide essential resources for microscopic evaluation of ocular tissues and extraction of biological data from images, thereby increasing the innovative capabilities of participating investigators for conducting productive vision research. The Core will provide equipment and technical expertise for performing histology, light/confocal and electron microscopy, live cell imaging, image analysis, and development/application of AI algorithms. The specific aims are to provide resources for: 1) performing histology of ocular tissue specimens; 2) enabling investigators to evaluate ocular tissues with the use of sophisticated light/confocal and electron microscopy and emerging imaging modalities; 3) training investigators and their research staff on the utility and operation of imaging equipment; 4) consultations on cell and tissue preparation and imaging for experimental design and appropriateness of techniques; 5) providing expertise and technical support for image analysis and development of AI methodologies.