Administrative Core

行政核心

• 批准号: 10714237
• 负责人: Robert E. Lewis
• 金额: $ 50.02万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-16 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714237
• 关键词: Acceleration; Advisory Committees; Biology; Biotechnology; Certification; Clinical; Communication; Complex; Creativeness; Data Analyses; Dedications; Detection; Development; Development Plans; Disease; Drug Industry; Effectiveness; Ensure; Environment; Etiology; Experimental Designs; Faculty; Fostering; Funding; Generations; Goals; Grant; Health; Human; Infrastructure; Investments; Laboratories; Lead; Leadership; Mentors; Mission; Molecular; Molecular Target; Nebraska; Outcome; Performance; Pilot Projects; Postdoctoral Fellow; Pre-Clinical Model; Procedures; Program Research Project Grants; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Secure; Series; System; Talents; Teacher Professional Development; Training; Universities; Update; Validation; Work; career; career development; cohort; design; doctoral student; experience; experimental study; human disease; improved; innovation; interest; knowledge translation; meetings; member; novel strategies; programs; recruit; senior faculty; skills; small molecule; tool; voucher

Project Summary: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development (CMTDD) leads, implements, and supports the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure facilitates the Center's effort to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core provides the organizational and programmatic leadership necessary to ensure the CMTDD works efficiently toward attaining its goal and is responsive to emerging research opportunities that improve its effectiveness. This effort includes continued implementation of Center-wide activities – including an annual retreat, monthly meetings of the CMTDD membership, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the CMTDD on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core coordinates a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Research Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core serves as a coordination point between CMTDD members and the Center's Scientific Cores. The Administrative Core supports research programs and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.

项目摘要：行政核心 内布拉斯加州分子靶标发现与开发中心（CMTDD） 领导、实施和支持中心的主要活动。这些活动包括建立关键的 基础设施，用于（1）识别疾病靶点，（2）产生操纵这些靶点的小分子， 目标，和（3）临床前模型的分析，其中评估这些目标的操作。创建 该基础设施有助于中心为有前途的新调查人员提供培训和指导 专注于发现改善疾病治疗的新方法。行政核心 提供必要的组织和计划领导，以确保CMTDD有效工作 努力实现其目标，并对提高其有效性的新兴研究机会作出反应。 这一努力包括继续开展全中心范围的活动，包括年度务虚会、每月 CMTDD成员会议，正式和非正式培训，以及对外部研讨会发言人的支持- 创造一个合作研究的环境，在国家一级促进CMTDD，并建立一个 中心成员实验室的优秀博士和博士后学生。行政核心 协调教师发展计划，包括研究项目计划和试点补助金计划 旨在加速有才华的研究项目领导人的独立过渡，并支持 开发多研究者赠款和方案项目。最后，行政核心作为一个 CMTDD成员和中心科学核心之间的协调点。行政核心 支持研究计划和相关的科学核心，以开发用于检测的创新工具， 验证分子靶点，并为实验设计和数据分析提供指导。