Administrative Core

项目摘要：管理核心 内布拉斯加州分子目标发现和开发中心(CMTDD)的管理核心 领导、实施和支持中心的主要活动。这些活动包括创建关键的 用于(1)识别疾病靶点，(2)产生操纵这些目标的小分子的基础设施 目标，以及(3)临床前模型分析，其中评估这些目标的操作。创建 这一基础设施有助于该中心努力向有前途的新调查人员提供培训和指导 重点是发现改进疾病治疗的新方法。行政核心 提供必要的组织和方案领导，以确保CMTDD高效工作 为实现其目标而努力，并对新出现的提高其有效性的研究机会作出反应。 这一努力包括继续实施中心范围的活动--包括每月举行的年度务虚会 CMTDD成员的会议、正式和非正式培训以及对外部研讨会发言者的支持-- 创造协作研究环境，在国家层面推动CMTDD，并建立 中心成员实验室中有才华的博士后和博士后。行政核心 协调包括研究项目计划和试点资助计划在内的教师发展计划 旨在加快有才华的研究项目负责人向独立性的过渡，并支持 开发多名研究人员的赠款和方案项目。最后，管理核心作为一个 CMTDD成员和中心科学核心之间的协调点。行政核心 支持研究计划和相关科学核心开发创新工具，用于检测和 验证分子靶标，并在实验设计和数据分析中提供指导。

Project Summary: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development (CMTDD) leads, implements, and supports the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure facilitates the Center's effort to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core provides the organizational and programmatic leadership necessary to ensure the CMTDD works efficiently toward attaining its goal and is responsive to emerging research opportunities that improve its effectiveness. This effort includes continued implementation of Center-wide activities – including an annual retreat, monthly meetings of the CMTDD membership, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the CMTDD on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core coordinates a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Research Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core serves as a coordination point between CMTDD members and the Center's Scientific Cores. The Administrative Core supports research programs and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.