Administrative Core

项目概要：行政核心 内布拉斯加州分子靶标发现和开发中心 (CMTDD) 的行政核心 领导、实施和支持中心的主要活动。这些活动包括创建关键 用于（1）识别疾病目标，（2）生成操纵这些目标的小分子的基础设施 目标，以及（3）临床前模型分析，以评估这些目标的操作。创造 该基础设施有助于该中心为有前途的新研究人员提供培训和指导 专注于发现改善疾病治疗的新方法。行政核心 提供必要的组织和计划领导，以确保 CMTDD 高效运作 致力于实现其目标，并对新出现的研究机会做出响应，以提高其有效性。 这项努力包括继续实施中心范围内的活动——包括年度务虚会、每月一次的活动 CMTDD 成员会议、正式和非正式培训以及对外部研讨会发言人的支持 – 创建协作研究环境，在国家层面推广 CMTDD，并建立人才库 中心成员实验室的优秀博士生和博士后学生。行政核心 协调教师发展计划，包括研究项目计划和试点资助计划 旨在加速有才华的研究项目负责人向独立性的转变，并支持 开发多研究者资助和计划项目。最后，行政核心作为 CMTDD 成员与中心科学核心之间的协调点。行政核心 支持研究计划和相关科学核心，开发用于检测和检测的创新工具 验证分子靶点并为实验设计和数据分析提供指导。

Project Summary: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development (CMTDD) leads, implements, and supports the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure facilitates the Center's effort to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core provides the organizational and programmatic leadership necessary to ensure the CMTDD works efficiently toward attaining its goal and is responsive to emerging research opportunities that improve its effectiveness. This effort includes continued implementation of Center-wide activities – including an annual retreat, monthly meetings of the CMTDD membership, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the CMTDD on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core coordinates a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Research Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core serves as a coordination point between CMTDD members and the Center's Scientific Cores. The Administrative Core supports research programs and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.