Administrative Core

项目摘要/摘要：行政核心 内布拉斯加州分子目标发现和开发中心的行政核心将领导， 实施并支持中心的主要活动。这些活动包括创建关键基础设施 用于(1)识别疾病靶标，(2)产生操纵这些靶标的小分子，以及 (3)临床前模型分析，用于评估这些靶点的操作。创造这样的东西 基础设施将促进该中心向有前途的新调查人员提供培训和指导的目标 重点是发现改进疾病治疗的新方法。行政核心 将提供必要的组织和方案领导，以确保中心高效工作 为实现其目标而努力，并对新出现的提高其有效性的研究机会作出反应。 这将包括实施全中心的活动--包括年度务虚会、正式和非正式培训、 并支持外部研讨会演讲者-创造一个合作的研究环境，促进 以国家级为中心，在国家实验室建设一批有才华的博士和博士后 中心成员。行政核心将协调包括研究在内的教师发展计划 项目计划和试点资助计划旨在加快有才华的项目负责人向 独立，并支持开发多名调查员的赠款和方案项目。最后， 行政核心将成为中心成员与中心科研人员之间的协调点 核心。行政核心将支持一项研究计划和相关科学核心的开发 用于检测和验证分子目标的创新工具，并在实验中提供指导 设计和数据分析。

Project Summary/Abstract: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development will lead, implement, and support the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure will facilitate the Center's goal to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core will provide the organizational and programmatic leadership necessary to ensure the Center works efficiently toward attaining its goal, and is responsive to emerging research opportunities that improve its effectiveness. This will include implementing Center-wide activities – including an annual retreat, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the Center on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core will coordinate a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core will serve as a coordination point between Center members and the Center's Scientific Cores. The Administrative Core will support a research program and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.