Administrative Core

项目概要/摘要：行政核心 内布拉斯加州分子靶点发现和开发中心的行政核心将领导， 支持和支持中心的主要活动。这些活动包括建立关键基础设施 用于（1）鉴定疾病靶标，（2）产生操纵这些靶标的小分子，以及 (3)分析临床前模型，以评估这些目标的操作。设立该 基础设施将有助于中心实现为有前途的新调查人员提供培训和指导的目标 专注于发现改善疾病治疗的新方法。行政核心 将提供必要的组织和方案领导，以确保中心有效运作 朝着实现其目标，并对提高其有效性的新兴研究机会作出反应。 这将包括开展全中心范围的活动，包括年度务虚会、正式和非正式培训， 和支持外部研讨会发言人-创造一个合作研究的环境，促进 以国家级为中心，在国家级实验室建立一个优秀的博士和博士后人才库， 中心成员。行政核心将协调教师发展计划，其中包括研究 项目计划和试点赠款计划，旨在加快有才华的项目领导人的过渡， 独立性和支持多研究者赠款和方案项目的发展。最后 行政核心将作为中心成员和中心科学中心之间的协调点。 丹行政核心将支持研究计划和相关的科学核心， 用于检测和验证分子靶点的创新工具，并为实验 设计和数据分析。

Project Summary/Abstract: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development will lead, implement, and support the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure will facilitate the Center's goal to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core will provide the organizational and programmatic leadership necessary to ensure the Center works efficiently toward attaining its goal, and is responsive to emerging research opportunities that improve its effectiveness. This will include implementing Center-wide activities – including an annual retreat, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the Center on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core will coordinate a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core will serve as a coordination point between Center members and the Center's Scientific Cores. The Administrative Core will support a research program and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.