Avian Influenza Vaccines for Pandemic Preparedness

用于预防流行病的禽流感疫苗

• 批准号: 7282756
• 负责人: DANIEL R PEREZ
• 金额: $ 25.23万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282756
• 关键词: Acute; Agriculture; American; Amino Acids; Animals; Antigens; Asia; Asians; Attenuated; Attenuated Live Virus Vaccine; Avian Influenza; Avian Influenza A Virus; Bird Flu vaccine; Birds; Cessation of life; Characteristics; Chickens; Country; Development; Discrimination; Disease; Disease Outbreaks; Domestic Fowls; Economics; Engineering; Genes; Genome; Goals; H5 hemagglutinin; Hemagglutinin; Human; Human Virus; Immune response; Infection; Influenza A Virus, H5N1 Subtype; Intervention; Life; Mammals; Mass Vaccinations; Meleagris gallopavo; Modeling; Molecular; Mus; Mutation; North America; Numbers; Pathogenesis; Phase; Phenotype; Policies; Quarantine; Range; Readiness; Recombinants; Reporting; Research Personnel; Seeds; Site; Temperature; Turkey bird; Vaccinated; Vaccination; Vaccines; Vietnam; Virus; Virus Diseases; aquatic bird; base; disorder control; immunogenicity; in vivo; influenzavirus; pandemic disease; pandemic influenza; positional cloning; prevent; programs; response; success; transmission process

DESCRIPTION (provided by applicant): Our long-term goal is to generate the information needed to prepare for or prevent the emergence of pandemic influenza viruses. There is particular concern about the possibility that avian influenza (Al) viruses of the H5N1 subtype could cause a pandemic. H5N1 viruses, endemic in domestic poultry in several Asian countries, have caused an alarming number of deaths by crossing from poultry to humans. Eradication, quarantine and vaccination policies have not succeeded in containing the disease, and the virus continues to be an omnipresent pandemic threat. Two mechanisms are contributing to the perpetuation of H5N1 viruses in Asia: their malleability to adapt to multiple animal species and reassert with other influenza viruses and their constant geographic expansion. The list of countries reporting outbreaks of H5N1 HPAI continues to increase despite the 160 million domestic poultry that have died or been culled in Asia to control the spread of the disease. The estimated economic losses to the Asian poultry sector are around $10 billion, threatening the livelihood of millions of people. This unprecedented outbreak of highly pathogenic avian influenza has taken a new twist having spread to migratory wild aquatic birds that could spread the virus to other parts of the world, including North America. This situation requires the development of intervention strategies that could bring the spread of these viruses to a halt. The goal of this R21 proposal is based on the hypothesis that by manipulating the genome of Al viruses, live attenuated vaccines can be prepared that will not only be useful for pandemic preparedness in humans but also for the control of the disease in animals. Our vaccine approach will allow ease of administration, mass vaccination of live attenuated viruses, and discrimination of vaccinated from infected birds, which ultimately will effectively control the spread of the disease.

描述(由申请者提供)：我们的长期目标是产生为预防或预防大流行性流感病毒出现所需的信息。特别令人关切的是，H5N1亚型禽流感病毒可能导致大流行。H5N1病毒在几个亚洲国家的家禽中流行，通过家禽传播给人类造成了令人震惊的死亡人数。根除、检疫和疫苗接种政策未能成功遏制该疾病，该病毒仍然是一个无处不在的大流行威胁。有两种机制促成了H5N1病毒在亚洲的持续传播：它们适应多种动物物种的可塑性，并与其他流感病毒一起重申其可塑性，以及它们在地理上的不断扩张。报告H5N1高致病性禽流感暴发的国家名单继续增加，尽管亚洲已有1.6亿只家禽死亡或被扑杀，以控制疾病的传播。据估计，亚洲家禽养殖业的经济损失约为100亿美元，威胁到数百万人的生计。这场史无前例的高致病性禽流感疫情出现了新的转折，传播到了迁徙的野生水禽，可能会将病毒传播到世界其他地区，包括北美。这种情况要求制定干预策略，以阻止这些病毒的传播。R21提案的目标是基于这样一种假设，即通过操纵甲型H1N1病毒的基因组，可以制备出不仅对人类大流行预防有用，而且对动物疾病控制有用的减毒活疫苗。我们的疫苗接种方法将使管理变得容易，大规模接种减毒活病毒，并区分接种的疫苗和受感染的禽类，最终将有效地控制疾病的传播。

项目成果

A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice.

一种新型单克隆抗体，可有效对抗猪系病毒和 2009 年大流行 H1N1 流感病毒对小鼠的致命攻击。

• DOI: 10.1016/j.virol.2011.06.021
• 发表时间: 2011
• 期刊: Virology
• 影响因子: 3.7
• 作者: Shao,Hongxia;Ye,Jianqiang;Vincent,AmyL;Edworthy,Nicole;Ferrero,Andrea;Qin,Aijian;Perez,DanielR
• 通讯作者: Perez,DanielR