The role of serotonin in the control of feeding behavior in Drosophila

血清素在控制果蝇摄食行为中的作用

• 批准号: 7332824
• 负责人: TIMOTHY D TAYLER
• 金额: $ 4.96万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7332824
• 关键词: Address; Adult; Affect; Animal Model; Behavior; Behavioral; Cells; Child; Circadian Rhythms; Collection; Complex; Data; Digestion; Drosophila genus; Drosophila melanogaster; Eating; Enhancers; Family; Feeding behaviors; G-Protein-Coupled Receptors; Gastrointestinal tract structure; Goals; Health; Hunger; Invertebrates; Locomotion; Molecular; Nervous system structure; Neurons; Neuropeptides; Neurotransmitters; Obesity; Organism; Overweight; Physiological Processes; Public Health; RNA Interference; Regulation; Research Proposals; Role; Satiation; Serotonin; Signal Transduction; System; Taste Perception; Transgenes; Transgenic Organisms; Vertebrates; cellular targeting; design; feeding; fly; gain of function; insight; loss of function; motivated behavior; neural circuit; receptor; serotonin receptor; transgene expression

DESCRIPTION (provided by applicant): Project summary: The major goal of this research proposal is to elucidate the function of serotonin (5-HT) in feeding and feeding-related behaviors in Drosophila melanogaster. 5-HT affects the feeding behavior of both vertebrates and invertebrates, however the precise molecular mechanisms by which this occurs are largely unknown. 5-HT also influences numerous other behaviors and physiological processes that could affect feeding such as locomotion, circadian rhythm and digestion. Using the genetically tractable fruit fly, I will address the following questions: How does 5-HT affect both feeding and other feeding-related behaviors? Are there specific subpopulations of 5-HT neurons that affect feeding directly? What is the role of the serotonin receptors in these behaviors? I will address these questions with the following specific aims: Aim 1. Loss-of-function and gain-of-function manipulations of 5-HT signaling. Aim 2. Identification and characterization of 5-HT neuronal subsets. Aim 3. Analysis of 5-HT receptors in feeding behavior. Relevance to public health: Obesity is a serious health concern that confronts millions of people worldwide. In the U.S., more than 65% of adults and 15% of children are considered overweight. Exploration of feeding behavior in model organisms will promote our understanding of how complex behavioral states, such as hunger and satiety, are controlled in the nervous system.

项目描述（申请人提供）：项目概述：本研究计划的主要目标是阐明5-羟色胺（5-HT）在果蝇摄食和摄食相关行为中的功能。5-HT影响脊椎动物和无脊椎动物的摄食行为，但其发生的精确分子机制在很大程度上是未知的。5-HT还影响许多其他可能影响进食的行为和生理过程，如运动，昼夜节律和消化。利用遗传学上易处理的果蝇，我将解决以下问题：5-HT如何影响进食和其他与进食相关的行为？是否存在直接影响摄食的5-HT神经元的特定亚群？5-羟色胺受体在这些行为中的作用是什么？我将以以下具体目标来解决这些问题：目标1。5-HT信号传导的功能丧失和功能获得操纵。目标2. 5-HT神经元亚群的鉴定和表征。目标3。摄食行为中5-HT受体的分析与公共卫生的相关性：肥胖是全世界数百万人面临的严重健康问题。在美国，超过65%的成年人和15%的儿童被认为超重。对模式生物摄食行为的探索将促进我们对复杂行为状态（如饥饿和饱足）如何在神经系统中控制的理解。