Reversal Learning in Pediatric Bipolar Disorder

小儿双相情感障碍的逆转学习

基本信息

批准号：
7091131
负责人：
DANIEL P DICKSTEIN
金额：
$ 15.08万
依托单位：
EMMA PENDLETON BRADLEY HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-14 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7091131
关键词：
Adolescent Adult Aggressive behavior Alzheimer&apos s Disease Americas Amygdaloid structure Anxiety Disorders Applications Grants Attention deficit hyperactivity disorder Base of the Brain Behavior Behavioral Behavioral Paradigm Bipolar Disorder Brain Child Child Mental Health Childhood Comorbidity Condition Corpus striatum structure Data Decision Making Diagnosis Diagnostic Diagnostic Specificity Differential Diagnosis Disease Doctor of Medicine Early Diagnosis Emotional Environment Event Experimental Designs Experimental Psychology Failure Functional Magnetic Resonance Imaging Functional disorder Goals Grant Health Care Costs Image Impairment Knowledge Laboratories Link Magnetic Resonance Imaging Maps Measures Mediating Methods Mission Morbidity - disease rate National Institute of Mental Health Neurobiology Neurologic Pharmaceutical Preparations Positioning Attribute Prefrontal Cortex Process Purpose Range Rate Relative (related person)Reproduction Research Research Personnel Resolution Resources Reversal Learning Rewards Social Characteristics Source Specificity Stimulus Structure Symptoms Testing Time Training Ventral Striatum Work base behavior measurement brain behavior clinical Diagnosis clinically relevant disease classification emotion regulation expectation experience innovation mortality neural circuit neuroimaging programs relating to nervous system research study response skills social

项目摘要

DESCRIPTION (provided by applicant): Bipolar disorder (BPD) in a major source of morbidity and mortality for adults in America, with more than $24 billion spent annually; however, far less is known about BPD in children and adolescents. Emerging data shows that BPD children are impaired in reversal learning. This process requires behavioral adaptation to changing stimulus-reward contingencies and engages the ventral prefrontal cortex (vPFC), ventral striatum, and amygdala. My long-term goal is to understand how brain/behavior interactions, central to emotion regulation, differentiate normal from psychiatrically ill children, in order to develop more effective diagnostic and treatment strategies. The study of reversal learning will facilitate my efforts in this respect. The objectives of this application are to (1) acquire training in fMRI methods and experimental design, (2) identify neurological correlates of impaired reversal learning in pediatric BPD, and (3) develop an R01 application based on this work. My central hypothesis is that BPD children have specific impairments in reversal learning due to dysfunction in a neural circuit encompassing the vPFC, ventral striatum, and amygdala. To test this hypothesis, I will: (1) use fMRI to identify substrates of reversal learning in normal children; (2) determine functional neuroanatomical and behavioral differences in BPD children during reversal learning; (3) evaluate the specificity of reversal learning deficits in psychiatric controls. I will use the "response reversal" task developed by our group to evaluate reversal learning with 3 Tesla fMRI and behavioral data. This will be among the first studies to link behavioral dysfunction to brain abnormalities in children with strictly defined BPD. From these studies, I expect to determine that BPD children have selective alterations in fronto-temporal structures during reversal learning. The proposed work will positively impact child mental health advancing our knowledge of the underlying brain/behavior abnormalities mediating BPD in children and adolescents. In turn, greater pathophysiological understanding of pediatric BPD will move the field of pediatric BPD beyond symptom-based diagnosis, potentially allowing more accurate or earlier diagnosis, thus reducing the morbidity and mortality in children and adolescents suffering from this debilitating disorder.

描述（由申请人提供）：美国成年人发病和死亡率的躁郁症（BPD），每年花费超过240亿美元；但是，关于儿童和青少年的BPD知之甚少。新兴数据表明，BPD儿童在逆转学习中受到损害。此过程需要行为适应改变刺激奖励的突发事件，并参与腹侧前额叶皮层（VPFC），腹侧纹状体和杏仁核。我的长期目标是了解大脑/行为相互作用如何与情绪调节的核心，将正常与精神病患者区分开来，以制定更有效的诊断和治疗策略。对逆转学习的研究将促进我在这方面的努力。该应用程序的目标是（1）获取fMRI方法和实验设计的培训，（2）确定儿科BPD中逆转性学习受损的神经系统相关性，以及（3）根据这项工作开发R01应用程序。我的中心假设是，由于涉及VPFC，腹侧纹状体和杏仁核的神经回路，BPD儿童在逆转学习方面具有特定的障碍。为了检验这一假设，我将：（1）使用fMRI识别正常儿童逆转学习的底物；（2）确定逆转学习过程中BPD儿童的功能性神经解剖学和行为差异；（3）评估精神病控制中逆转学习缺陷的特异性。我将使用我们小组开发的“响应逆转”任务来评估3个特斯拉fMRI和行为数据的逆转学习。这将是最早将行为功能障碍与严格定义BPD儿童的脑异常联系起来的研究之一。从这些研究中，我希望在逆转学习过程中确定BPD儿童在额颞结构中有选择性改变。拟议的工作将对儿童心理健康产生积极影响，以促进我们对介导儿童和青少年BPD的潜在大脑/行为异常的了解。反过来，对小儿BPD的病理生理理解将使小儿BPD的领域超越基于症状的诊断，从而有可能更准确或更早的诊断，从而降低患有这种衰弱障碍的儿童和青少年的发病率和死亡率。