Experience-dependent tuning of socially selective neural circuits

社会选择性神经回路的经验依赖调节

• 批准号: 10723708
• 负责人: Christopher M Jernigan
• 金额: $ 12.5万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723708
• 关键词: Address; Adult; Affect; Age; Animals; Area; Award; Behavior; Behavioral; Brain; Cells; Central Nervous System; Classification; Color; Complex; Coupled; Cues; Detection; Development; Developmental Process; Dimensions; Discrimination; Elderly; Electrophysiology (science); Eye; Face; Female; Future; Goals; Growth; Health; Human; Image; Individual; Invertebrates; Laboratory Study; Measures; Mediating; Memory; Modality; Modeling; Nervous System; Neuroanatomy; Neurons; Paper; Personal Satisfaction; Phase; Physiological; Population; Primates; Property; Research; Shapes; Siblings; Social Development; Social Discrimination; Social Environment; Social Identification; Social Interaction; Social Reinforcement; Social isolation; Sorting; Synapses; System; Techniques; Temporal Lobe; Testing; Time; Training; Universities; Vision; Visual; Wasps; Work; behavioral response; brain shape; brain volume; career; design; emerging adult; experience; experimental study; innovation; neural; neural circuit; nonhuman primate; novel; response; social; social cognition; social group; social relationships; statistics; visual stimulus

PROJECT SUMMARY Appropriately recognizing and responding to social partners is a fundamental principle guiding every social interaction from single cells to humans. Social environment is known to interact with development to give rise to typical behavioral responses, however the mechanisms by which social experience shapes the development and tuning features of the nervous system to give rise to these behaviors remains poorly understood. How does the social environment throughout development interact to shape how the brain encodes and discriminates social information? The proposed research addresses these questions in a novel experimentally tractable system for investigating social development of a neural circuit, the northern paper wasp, Polistes fuscatus. P. fuscatus females have highly diverse color markings on their face which they use to discriminate social partners via vision alone. Like humans, P. fuscatus wasps treat faces as special visual objects and the development of this specialized recognition ability is dependent on social experience. The social lives of these wasps are rich and complex, allowing for highly refined social memory and even transitive inference of social relationships. Conveniently, wasps do not possess image forming eyes prior to adult emergence. This key feature allows for the ability to precisely control both the timing and diversity of social experience, while maintaining normal larval development. Further, we have recently discovered a common population of socially responsive neurons in the central brain of P. fuscatus, which show selective tuning to visual stimuli of forward- facing wasps above other visual objects, analogous to the ‘face cells’ in the primate brain. These cells encode both social detection and identity discrimination, providing a clear neural target to study how social experience shapes the tuning features of a socially selective circuits. The proposed experiments take advantage of the unique strengths of this system to address this question at three levels. First, we will assess how these circuits are impacted by long-term social isolation. Second, we will track the developmental tuning trajectory of these circuits to identify how these circuits develop and are refined through maturity to give rise to the highly selective features found in mature adult wasps. Third, we will investigate how both individual neural and population-level tuning features are affected by the diversity of social experiences wasps have, via manipulation of facial diversity among groups. These experiments will aid in discovering fundamental features of how social circuits are tuned via social experience and guide future experiments to identify shared principles guiding social cognition. Further this award will also support the awardee’s transition to an independent research career at a research-intensive university and support the establishment of their laboratory studying how social experience shapes the development of circuits underlying social cognition.

项目总结 正确认识和回应社会伙伴是指导每个社会团体的基本原则 从单细胞到人类的相互作用。众所周知，社会环境与发展相互作用，从而产生 然而，对于典型的行为反应，社会经验塑造发展的机制 而调节神经系统的功能以产生这些行为仍然知之甚少。多么 整个发育过程中的社会环境是否相互作用，以塑造大脑的编码和 歧视社会信息？这项拟议的研究在一项新的实验中解决了这些问题 用于研究神经回路社会发展的易处理系统，北方纸蜂，Polistes Fuscatus。褐斑潜蝇雌性在脸上有高度多样化的颜色斑纹，它们用这些斑纹来区分 仅通过视觉的社交伙伴。像人类一样，褐飞虱将人脸视为特殊的视觉对象，而 这种特殊认知能力的发展依赖于社会经验。这些人的社会生活 黄蜂是丰富和复杂的，允许高度精炼的社会记忆，甚至传递性的社会推理 两性关系。便利的是，黄蜂在成虫羽化之前没有形成图像的眼睛。这把钥匙 功能允许精确控制社交体验的时间和多样性，同时 维持幼虫的正常发育。此外，我们最近发现了一个共同的社会群体 中央脑内的反应神经元对前向视觉刺激表现出选择性的调谐。 面对黄蜂高于其他视觉物体，类似于灵长类动物大脑中的“面细胞”。这些细胞编码 社会检测和身份歧视，为研究社会体验提供了一个明确的神经目标 塑造了社会选择电路的调谐功能。拟议中的实验利用了 这一系统具有独特的优势，可以在三个层面上解决这一问题。首先，我们将评估这些电路是如何 受到长期的社会孤立的影响。第二，我们将跟踪这些项目的发展调整轨迹 电路，以确定这些电路是如何发展和完善的，以产生高度的 在成熟的成年黄蜂身上发现的选择性特征。第三，我们将研究个体神经和 种群水平的调整特征受到黄蜂社会经验的多样性的影响，通过 操纵不同群体之间的面部多样性。这些实验将有助于发现基本特征 如何通过社会经验调整社交网络，并指导未来的实验以确定共同的原则 引导社会认知。此外，该奖项还将支持获奖者向独立的 在研究密集型大学从事研究工作，并支持他们建立实验室学习 社会经验如何塑造潜在的社会认知回路的发展。