Acute vs Chronic Stress-Enhanced Fear Learning

急性与慢性压力增强的恐惧学习

基本信息

项目摘要

Project Abstract Stress can have a profound detrimental impact on our behavior, predisposing us to anxiety disorders such as post-traumatic stress disorder and major depression. Given the high prevalence of these disorders understanding the basic biological and psychological processes is vitally important if we wish to address these significant problems and develop effective treatments. One question in the literature is whether a single (acute) exposure to stress or repeated (chronic) stress has similar effects. A second question is how severe must stress be in order to produce detrimental effects. Do repeated mild stressful experiences have an added impact that equals that of a more severe acute stressor? Does chronic stress exposure have a greater impact than an equally intense acute stressful experience? Surprisingly, while there is a large basic science literature on stress, that literature simply does not answer these questions. This is because the methods employed have totally confounded the chronic nature of stress with its severity. Typically what is compared are a series of repeated stressors to a single instance of the same stress. But repeated instances mean that the stress is not only chronic it is also, in total, more severe. We have developed a method were we can independently manipulate the chronicity and severity of stress that will for the first time allow us to accurately answer these important questions. The work begins from our extensive use of an intense acute stressor and the database we have collected on its effects on physiology and behavior. The design of our acute stressor allows us to break it into 15 “bits” than can be administered at one bit a day for 15 days because the acute stress repeats the same aversive stimulus 15 times over 90 min. We can also systematically vary the intensity of our aversive experience. Our preliminary data already indicate that chronic and acute stress provokes different behavioral responses. Our first aim tests the hypothesis that the differences occur because acute stress taps into a set of automatic “nonassociative” processes while chronic stress taps into learning or associative conditioning processes. Our second aim focuses on the physiological and neural changes that are differentially provoked by chronic vs acute stressors. Additionally, we will determine to what extent stress severity and not chronicity is the culprit. The third aim focuses on manipulations designed to block the effects of stress to help elucidate how stress chronicity and severity produce their effects via different biological mechanisms. We also hypothesize that males and females have different thresholds for how severe a stressor must be to provoke maladaptive changes in behavior. That hypothesis if true can begin to help explain why anxiety disorders and depression are more prevalent in females.
项目摘要

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray.
Negative valence systems: sustained threat and the predatory imminence continuum.
Dissociable consequences of moderate and high volume stress are mediated by the differential energetic demands of stress.
  • DOI:
    10.1371/journal.pone.0273803
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.7
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Michael S Fanselow其他文献

Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress
急性创伤应激所致恐惧敏感化的诱导与表达
  • DOI:
    10.1038/npp.2015.224
  • 发表时间:
    2015-08-06
  • 期刊:
  • 影响因子:
    7.100
  • 作者:
    Jennifer N Perusini;Edward M Meyer;Virginia A Long;Vinuta Rau;Nathaniel Nocera;Jacob Avershal;James Maksymetz;Igor Spigelman;Michael S Fanselow
  • 通讯作者:
    Michael S Fanselow

Michael S Fanselow的其他文献

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{{ truncateString('Michael S Fanselow', 18)}}的其他基金

Mechanisms of enhanced synaptic drive in basolateral amygdala following stress
应激后基底外侧杏仁核突触驱动增强的机制
  • 批准号:
    10723781
  • 财政年份:
    2023
  • 资助金额:
    $ 37.94万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9977941
  • 财政年份:
    2017
  • 资助金额:
    $ 37.94万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9484109
  • 财政年份:
    2017
  • 资助金额:
    $ 37.94万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    10219943
  • 财政年份:
    2017
  • 资助金额:
    $ 37.94万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9750570
  • 财政年份:
    2017
  • 资助金额:
    $ 37.94万
  • 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
  • 批准号:
    8600320
  • 财政年份:
    2012
  • 资助金额:
    $ 37.94万
  • 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
  • 批准号:
    8463349
  • 财政年份:
    2012
  • 资助金额:
    $ 37.94万
  • 项目类别:
Complete Fear Conditioning Suite for Rats and Mice
大鼠和小鼠的完整恐惧调节套件
  • 批准号:
    7794560
  • 财政年份:
    2010
  • 资助金额:
    $ 37.94万
  • 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
  • 批准号:
    7938672
  • 财政年份:
    2009
  • 资助金额:
    $ 37.94万
  • 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
  • 批准号:
    7810977
  • 财政年份:
    2009
  • 资助金额:
    $ 37.94万
  • 项目类别:

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