Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy
社区赋权、血管风险和 ADRD 差异:将研究转化为公共政策
基本信息
- 批准号:10723077
- 负责人:
- 金额:$ 12.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanAreaAwardBlack PopulationsBlack raceBlood VesselsCaliforniaCardiovascular DiseasesCensusesCharacteristicsClinicalCollaborationsCommunitiesCommunity SurveysCountyDataData ScienceDepressed moodDeteriorationDevelopmentDisparityEconomic FactorsEconomicsElderlyEnsureEventExclusionFacultyFoundationsFutureGoalsHealth Care CostsHealth PolicyHealth and Retirement StudyHousingIncidenceInfrastructureInstitutionInterventionInvestmentsJointsKnowledgeLeadLinkLow incomeMachine LearningMediatingMediatorMedicareMedicare claimMentorsMentorshipMinorityModelingNeighborhoodsPatternPhasePoliciesPolitical FactorPoliticsPopulationPopulation Attributable RisksPositioning AttributePrevalencePreventionPublic HealthPublic PolicyRaceRacial SegregationReasons for Geographic And Racial Differences in StrokeRelative RisksResearchResearch PersonnelResourcesRiskRisk EstimateRisk FactorsRoleSamplingSan FranciscoScienceSocial EnvironmentStroke BeltStructural RacismSurveysTrainingTranslatingUniversity resourcesVariantbeneficiaryblack/white disparityburden of illnesscardiovascular disorder epidemiologycardiovascular disorder riskcardiovascular effectscohortcommunity-level factorcultural competencedementia riskdemographicsdisparity reductioneconomic indicatorempowermentinnovationmarginalizationmortalityneighborhood disadvantagepolicy implicationpreventracial disparityresidencescale upsegregationskillssocioeconomicssuccesssystemic barrier
项目摘要
PROJECT SUMMARY ABSTRACT
By 2050, racial disparities will persist among the projected 11 million adults with Alzheimer’s Disease and
Related Dementias (AD/ADRD). Prior research links racial segregation to AD/ADRD, highlighting the
need for structural solutions to mitigate the racially patterned cardiovascular disease (CVD) burden that
accelerates AD/ADRD onset. Economic disinvestment prevents Black, poor, and Stroke Belt
neighborhoods from investing in their local infrastructure, while systemic barriers lead to political
disenfranchisement among the very historically excluded groups who would benefit most from effective
health policy. However, it is not known how disinvestment and disenfranchisement—factors produced by
structural racism—contribute to AD/ADRD disparities via excess CVD risk.
This proposed K99/R00 harnesses the Reasons for Geographic and Racial Differences in Stroke
(REGARDS) Study, Health and Retirement Study (HRS), and administrative claims from Medicare
Beneficiaries. For my K99 phase, I will identify indicators of economic disinvestment and political
disenfranchisement that worsen AD/ADRD trajectories and widen racial disparities in REGARDS and
HRS. Then I will use these results to calculate the population attributable fraction of disinvestment and
disenfranchisement on AD/ADRD among Medicare Beneficiaries. During my R00 phase, I will analyze the
mediating role of CVD in associations of disinvestment or disenfranchisement and incident AD/ADRD in
Medicare claims. Finally, I will utilize the CVD Policy Model to forecast nationwide community
empowerment policies to reduce CVD risk factors for AD/ADRD up to three decades in the future.
Building upon my foundation of data science, causal inference, and CVD epidemiology, my training plan
consists of new knowledge domains: 1) AD/ADRD science, 2) spatial modeling, 3) Medicare claims, and
4) estimation of public health impact attainable with structural interventions.
Based at the richly resourced University of California, San Francisco, I have assembled a team of
distinguished mentors with the ideal combination of expertise to facilitate my success. The integrated
science, training, mentorship, and professional development will prepare me for a faculty position at an
R1 institution. My longterm goal is to become an independent investigator who develops interventions and
policies to prevent AD/ADRD among low-income, Black, and Stroke Belt communities.
项目摘要
到2050年,预计1100万老年痴呆症患者中的种族差异将持续存在,
相关痴呆(AD/ADRD)。先前的研究将种族隔离与AD/ADRD联系起来,强调了
需要结构性解决方案,以减轻种族模式的心血管疾病(CVD)负担,
加速AD/ADRD发作。经济撤资防止黑人,穷人和中风带
社区投资当地基础设施,而系统性障碍导致政治
在历史上被排斥的群体中,
卫生政策。然而,目前还不知道如何撤资和剥夺公民权的因素产生的
结构性种族歧视-通过过度CVD风险导致AD/ADRD差异。
这一拟议的K99/R 00利用了卒中的地理和种族差异的原因
(关注)研究、健康与退休研究(HRS)和Medicare的行政索赔
受益人。在我的K99阶段,我将确定经济撤资和政治撤资的指标。
剥夺公民权,使AD/ADRD的发展轨迹恶化,并扩大了REGARDS和
HRS.然后,我将使用这些结果来计算人口可归因于撤资的比例,
医疗保险受益人中AD/ADRD的权利被剥夺。在R 00阶段,我将分析
心血管疾病在减少投资或剥夺公民权与AD/ADRD事件之间的中介作用
医疗保险索赔。最后,利用CVD政策模型对全国范围内的社区进行预测
在未来30年内,增强政策以减少AD/ADRD的CVD风险因素。
基于我的数据科学,因果推理和CVD流行病学基础,我的培训计划
包括新的知识领域:1)AD/ADRD科学,2)空间建模,3)医疗保险索赔,
4)估计通过结构性干预措施可达到的公共卫生影响。
在资源丰富的加州大学旧金山分校弗朗西斯科,我组建了一个团队,
杰出的导师与专业知识的理想结合,以促进我的成功。集成
科学,培训,指导和专业发展将准备我在一个教师职位
R1机构。我的长期目标是成为一名独立的研究人员,开发干预措施,
在低收入、黑人和中风带社区中预防AD/ADRD的政策。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Projected Impact of Nonpharmacologic Management of Stage 1 Hypertension Among Lower-Risk US Adults.
非药物治疗对低风险美国成年人 1 期高血压的预计影响。
- DOI:10.1101/2023.12.26.23300563
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Sims,KendraD;Wei,PengxiaoCarol;Penko,JoanneM;Hennessy,Susan;Coxson,PamelaG;Mukand,NitaH;Bellows,BrandonK;Kazi,DhruvS;Zhang,Yiyi;Boylan,Ross;Moran,AndrewE;Bibbins-Domingo,Kirsten
- 通讯作者:Bibbins-Domingo,Kirsten
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Kendra D Sims其他文献
Associations of Everyday and Lifetime Experiences of Discrimination With Willingness to Undergo Alzheimer Disease Predictive Testing.
日常和一生的歧视经历与接受阿尔茨海默病预测测试的意愿之间的关联。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:9.9
- 作者:
Tanisha G. Hill;Minhyuk Choi;P. Buto;Silvia Miramontes;Marilyn D Thomas;Yulin Yang;Min Hee Kim;Kendra D Sims;M. M. Glymour - 通讯作者:
M. M. Glymour
Association of Cancer History with Structural Brain Aging Markers of Alzheimer's Disease and Dementia Risk
癌症史与阿尔茨海默病和痴呆风险的结构性脑老化标志物的关联
- DOI:
10.1101/2023.02.19.23286154 - 发表时间:
2023 - 期刊:
- 影响因子:5.7
- 作者:
J. Wang;Kendra D Sims;S. Ackley;R. Chen;L. Kobayashi;E. Hayes‐Larson;E. Mayeda;P. Buto;S. Zimmerman;R. E. Graff;M. M. Glymour - 通讯作者:
M. M. Glymour
Abstract 055: Neighborhood-Wide Association Study Of Hypertension In The Health And Retirement Study
摘要 055:健康和退休研究中高血压的全社区协会研究
- DOI:
10.1161/circ.145.suppl_1.055 - 发表时间:
2022 - 期刊:
- 影响因子:37.8
- 作者:
Kendra D Sims;P. Hystad;G. D. Batty;E. Smit;Jessina C. McGregor;M. Odden - 通讯作者:
M. Odden
Kendra D Sims的其他文献
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