Daily Memory Lapses and Sympathetic-Cardiovascular Dysfunction: Pathways to Prevention of Alzheimer's Disease and Related Dementias (ADRD)

日常记忆衰退和交感心血管功能障碍：预防阿尔茨海默病和相关痴呆症 (ADRD) 的途径

• 批准号: 10724860
• 负责人: Jody Greaney
• 金额: $ 31.86万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724860
• 关键词: Acceleration; Accounting; Acute; Adult; Affective; Age; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Applications Grants; Area; Blood Pressure; Blood Vessels; Cardiovascular Physiology; Cardiovascular system; Cerebrum; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Collaborations; Color; Data; Data Analyses; Early Intervention; Emotional; Emotions; Equation; Event; Exposure to; Frequencies; Functional disorder; Future; Health; Hypertension; Impaired cognition; Individual; Individual Differences; Intervention; Laboratories; Life; Link; Longevity; Major Depressive Disorder; Measurement; Measures; Memory; Mental Depression; Modeling; Names; Neurocognitive; Neurocognitive Deficit; Participant; Pathway interactions; Perception; Physiological; Physiological Processes; Prevention; Research; Risk; Risk Factors; Severities; Standardization; Stress; Techniques; Testing; Time; Work; arterial stiffness; associated symptom; clinically relevant; cognitive task; critical period; depressive symptoms; diaries; emotional distress; emotional experience; experience; forgetting; high risk; high risk population; innovation; insight; lifestyle intervention; middle age; mild cognitive impairment; negative affect; neural circuit; prevent; psychologic; response; stressor; symptomatology; treatment strategy; young adult

PROJECT SUMMARY The current project will examine whether and how negative affective responsivity to daily memory lapses is related to sympathetic-cardiovascular dysfunction in young, healthy adults. Daily memory lapses are a common, everyday experience that cause emotional distress among some adults regardless of age. Our previous work demonstrates that this emotional distress is heightened among young adults and persists even after accounting for other types of daily stress experiences (e.g., arguments or work stressors). Given that emotional distress in response to stressors is associated with a number of physical, emotional, and cognitive health consequences, it is critical to identify the physiological pathways that link daily experiences of emotional distress like negative affective responsivity to broader cardiovascular functioning. Further, as individuals higher in depressive symptoms are more likely to experience negative affective responsivity and cardiovascular dysfunction, depressive symptoms are a key individual difference factor that may make individuals more vulnerable to these pathways. This secondary data analysis aims to daily diary assessments of memory lapses and their impacts on daily emotions to direct lab-based assessments of micro-vascular functioning. We will use multilevel structural equation modeling to examine three primary aims: 1) examine how frequency of daily memory lapses relates to sympathetic-cardiovascular dysfunction; 2) examine how negative affective responsivity to daily memory lapses relates to sympathetic-cardiovascular dysfunction; and 3) determine whether level of depressive symptoms moderates these relations. This application combines innovative approaches that allow more precise measurement of both the experience of daily problems with memory and the physiological processes responsible for a wide range of health conditions including hypertension, major depressive disorder, and eventually Alzheimer’s disease. This work capitalizes on previously collected data to efficiently generate new research that will help identify intervention targets for the promotion of healthier cognitive aging that can be implemented earlier in the life span to prevent cognitive decline.

项目摘要 当前的项目将检查对每日记忆失误的负面情感反应性以及如何 与年轻，健康成年人的交感神经性心血管功能障碍有关。每日记忆失误是一个 常见的是，无论年龄多大，每天都会导致某些成年人的情绪困扰。我们的 以前的工作表明，这种情绪困扰在年轻人中加剧，甚至持续 在考虑了其他类型的日常压力经历（例如论点或工作压力源）之后。鉴于 响应压力源的情绪困扰与许多身体，情感和认知有关 健康后果，至关重要 苦难像对更广泛的心血管功能的负面情感反应性。此外，随着个人的越高 在抑郁症状中，更有可能经历负面情感反应性和心血管 功能障碍，抑郁症状是可能使个人更多的个体差异因素 容易受到这些途径的影响。该二次数据分析旨在每天日记评估记忆失误 以及它们对日常情绪的影响，直接基于实验室的微血管功能评估。我们将使用 多级结构方程模型，以检查三个主要目的：1）检查日常的频率 记忆失误与交感神经功能障碍有关； 2）检查如何负面情感 对每日记忆失误的反应与交感神经功能障碍有关； 3）确定 抑郁症状水平是否适应这些关系。该应用程序结合了创新 可以更精确地测量每日记忆问题的经验和 负责各种健康状况的物理过程，包括高血压，主要 抑郁症，最终是阿尔茨海默氏病。这项工作大写了先前收集的数据 有效地产生新的研究，以帮助确定促进更健康的干预目标 可以在生命周期中早期实施的认知衰老，以防止认知能力下降。