Daily Memory Lapses and Sympathetic-Cardiovascular Dysfunction: Pathways to Prevention of Alzheimer's Disease and Related Dementias (ADRD)

日常记忆衰退和交感心血管功能障碍：预防阿尔茨海默病和相关痴呆症 (ADRD) 的途径

• 批准号: 10724860
• 负责人: Jody Greaney
• 金额: $ 31.86万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724860
• 关键词: Acceleration; Accounting; Acute; Adult; Affective; Age; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Applications Grants; Area; Blood Pressure; Blood Vessels; Cardiovascular Physiology; Cardiovascular system; Cerebrum; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Collaborations; Color; Data; Data Analyses; Early Intervention; Emotional; Emotions; Equation; Event; Exposure to; Frequencies; Functional disorder; Future; Health; Hypertension; Impaired cognition; Individual; Individual Differences; Intervention; Laboratories; Life; Link; Longevity; Major Depressive Disorder; Measurement; Measures; Memory; Mental Depression; Modeling; Names; Neurocognitive; Neurocognitive Deficit; Participant; Pathway interactions; Perception; Physiological; Physiological Processes; Prevention; Research; Risk; Risk Factors; Severities; Standardization; Stress; Techniques; Testing; Time; Work; arterial stiffness; associated symptom; clinically relevant; cognitive task; critical period; depressive symptoms; diaries; emotional distress; emotional experience; experience; forgetting; high risk; high risk population; innovation; insight; lifestyle intervention; middle age; mild cognitive impairment; negative affect; neural circuit; prevent; psychologic; response; stressor; symptomatology; treatment strategy; young adult

PROJECT SUMMARY The current project will examine whether and how negative affective responsivity to daily memory lapses is related to sympathetic-cardiovascular dysfunction in young, healthy adults. Daily memory lapses are a common, everyday experience that cause emotional distress among some adults regardless of age. Our previous work demonstrates that this emotional distress is heightened among young adults and persists even after accounting for other types of daily stress experiences (e.g., arguments or work stressors). Given that emotional distress in response to stressors is associated with a number of physical, emotional, and cognitive health consequences, it is critical to identify the physiological pathways that link daily experiences of emotional distress like negative affective responsivity to broader cardiovascular functioning. Further, as individuals higher in depressive symptoms are more likely to experience negative affective responsivity and cardiovascular dysfunction, depressive symptoms are a key individual difference factor that may make individuals more vulnerable to these pathways. This secondary data analysis aims to daily diary assessments of memory lapses and their impacts on daily emotions to direct lab-based assessments of micro-vascular functioning. We will use multilevel structural equation modeling to examine three primary aims: 1) examine how frequency of daily memory lapses relates to sympathetic-cardiovascular dysfunction; 2) examine how negative affective responsivity to daily memory lapses relates to sympathetic-cardiovascular dysfunction; and 3) determine whether level of depressive symptoms moderates these relations. This application combines innovative approaches that allow more precise measurement of both the experience of daily problems with memory and the physiological processes responsible for a wide range of health conditions including hypertension, major depressive disorder, and eventually Alzheimer’s disease. This work capitalizes on previously collected data to efficiently generate new research that will help identify intervention targets for the promotion of healthier cognitive aging that can be implemented earlier in the life span to prevent cognitive decline.

项目摘要 目前的项目将研究是否以及如何消极情感反应日常记忆的失误， 与年轻健康成人的交感心血管功能障碍有关。日常记忆缺失是一种 常见的，日常的经验，造成情绪困扰的一些成年人，无论年龄。我们 以前的研究表明，这种情绪困扰在年轻人中更为严重，甚至持续存在， 在考虑了其他类型的日常压力经历（例如，工作压力（stressors）。鉴于 对压力源的情绪困扰与许多身体、情绪和认知方面的因素有关。 健康的后果，这是至关重要的，以确定生理途径，连接日常经验的情绪 对更广泛的心血管功能的负面情感反应。此外，作为个体， 在抑郁症状中，更有可能经历消极的情感反应和心血管反应， 功能障碍，抑郁症状是一个关键的个体差异因素，可能使个人更多 易受这些途径的影响。这一次要数据分析的目的是每日日记评估记忆丧失 以及它们对日常情绪的影响，以指导基于实验室的微血管功能评估。我们将使用 多层次结构方程模型研究三个主要目标：1）研究日常频率 记忆丧失与交感心血管功能障碍有关; 2）检查负性情感如何影响 对日常记忆丧失的反应性与交感心血管功能障碍有关; 3）确定 抑郁症状的程度是否调节这些关系。该应用程序结合了创新的 这种方法可以更精确地测量日常记忆问题的经历， 生理过程负责广泛的健康状况，包括高血压，主要 抑郁症，最终导致老年痴呆症这项工作利用以前收集的数据， 有效地产生新的研究，这将有助于确定干预目标，以促进更健康的 认知老化，可以在生命的早期实施，以防止认知能力下降。