A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy

利用散斑对比光学光谱进行功能性脑成像的变革性方法

• 批准号: 10724661
• 负责人: David A Boas
• 金额: $ 41.73万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724661
• 关键词: Adoption; Adult; Brain; Brain Injuries; Brain imaging; Cerebrovascular Circulation; Cerebrum; Child; Device or Instrument Development; Diffuse; Disease; Environment; Fiber; Functional Magnetic Resonance Imaging; Future; Geometry; Health; Hemoglobin; Human; Image; Imaging Device; Imaging Techniques; Infant; Measurement; Measures; Metabolism; Methods; Modeling; Monitor; Motion; Near-Infrared Spectroscopy; Neurodegenerative Disorders; Noise; Optical Methods; Optics; Oxygen; Pathologic; Patient Monitoring; Pattern; Performance; Phase; Photons; Population; Resolution; Semiconductors; Signal Transduction; Source; Specificity; Spectrum Analysis; System; Time; Variant; Work; brain computer interface; cerebral hemodynamics; cost; cranium; data analysis pipeline; density; detector; functional near infrared spectroscopy; hemodynamics; imaging modality; improved; metabolic rate; metal oxide; neuroimaging; non-invasive monitor; novel strategies; portability; response; temporal measurement; tomography; tool; wearable device

Abstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring patients with brain injuries or neurodegenerative disease, studies of brain function in natural environments, and brain-computer interfaces. Among the various brain imaging techniques, functional near infrared spectroscopy (fNIRS) is an optical method that images the hemodynamic response to brain activation by measuring the oxy-(HbO) and deoxy-(HbR) hemoglobin concentration changes due to brain activation. It is especially useful for populations and for studies for which other imaging modalities are limited, e.g. functional magnetic resonance imaging (fMRI), including for children, infants, and studies that involve motion and interactions or require high temporal resolution. However, fNIRS brain sensitivity in adult humans is typically around 10%, and fNIRS alone does not provide quantitative information about all the hemodynamic parameters as it does not measure changes in cerebral blood flow (CBF). Here, we propose to develop a fiber-based speckle contrast optical spectroscopy (SCOS) system to measure CBF variations due to brain activation in humans. SCOS uses relatively low-cost complementary metal–oxide– semiconductor (CMOS) cameras as detectors. The performance of SCOS can surpass that of existing optical systems for human measurements of CBF in terms of contrast to noise ratio (CNR) by at least one order of magnitude with equal or less cost. The combined SCOS-fNIRS system developed in the UG3 phase will provide measurements of all the hemodynamic parameters associated with brain activation, achieve an up to 3x improvement in brain sensitivity compared with fNIRS alone, and permit estimation of evoked changes in CMRO2. The high-density SCOS-fNIRS system developed in the UH3 phase will provide images of all the hemodynamic parameters with high spatial and temporal resolution. This work will result in a new approach for functional brain imaging and demonstrative results that will motivate adoption by others and future advancements towards wearable devices at a reduced cost.

摘要 在正常和病理条件下对人脑功能进行无创监测的进展将导致 我们对大脑在健康和疾病中的理解取得了突破，并导致了设备的发展， 可用于日常使用，应用程序包括监测脑损伤或神经退行性疾病患者 疾病，自然环境中的脑功能研究，以及脑机接口。的各种 脑成像技术，功能性近红外光谱（fNIRS）是一种光学方法， 通过测量氧合血红蛋白（HbO）和脱氧血红蛋白（HbR）对脑激活的血流动力学反应 由于大脑活动而引起的浓度变化。它对于以下人群和研究特别有用： 其他成像模式受到限制，例如功能性磁共振成像（fMRI），包括用于儿童， 婴儿，以及涉及运动和相互作用或需要高时间分辨率的研究。然而，fNIRS 成年人的大脑灵敏度通常在10%左右，单独的fNIRS不能提供定量的 因为它不测量脑血流量（CBF）的变化，所以它可以提供有关所有血液动力学参数的信息。 在这里，我们建议开发一种基于光纤的散斑衬度光谱（SCOS）系统来测量 由于人类大脑激活引起的CBF变化。SCOS使用相对低成本的互补金属氧化物， 半导体（CMOS）相机作为检测器。SCOS的性能可以超过现有的光学 根据对比度噪声比（CNR）的CBF的人类测量系统， 以相等或更少的成本。在UG 3阶段开发的组合SCOS-fNIRS系统将提供 与大脑激活相关的所有血液动力学参数的测量，实现了高达3倍的 与单独的fNIRS相比，脑灵敏度的改善，并允许估计诱发的变化， CMRO 2. UH 3阶段开发的高密度SCOS-fNIRS系统将提供所有 具有高空间和时间分辨率的血流动力学参数。这项工作将导致一种新的方法， 功能性脑成像和演示结果，将激励其他人采用和未来的进步 以降低的成本转向可穿戴设备。

项目成果

Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

• DOI: 10.1038/s42003-023-05211-4
• 发表时间: 2023-08-14
• 期刊: COMMUNICATIONS BIOLOGY
• 影响因子: 5.9
• 作者: Kim, Byungchan;Zilpelwar, Sharvari;Sie, Edbert J.;Marsili, Francesco;Zimmermann, Bernhard;Boas, David A.;Cheng, Xiaojun
• 通讯作者: Cheng, Xiaojun