Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)

项目摘要 我们建议在全国范围内进行一项基于湾区人群的前瞻性队列研究， 亚裔美国人（阿萨）男性和女性，以解决相关因素和决定因素证据中的主要差距 疾病风险和健康。我们将招募，描述和跟踪中国，菲律宾和越南人 美国人，三个未被充分研究的阿萨族群，他们的人口在美国迅速增长， States.具体来说，我们将招募2,100名中国人、菲律宾人和越南裔美国人（每种族裔700人 组）在旧金山弗朗西斯科湾区，以表征心脏代谢概况和社会心理及其他 通过广泛的调查，临床评估和分析，成像研究，多组学， 数字技术虽然不同的阿萨组的疾病模式和危险因素似乎不同， 先前的研究表明AsAs受到心脏代谢紊乱如糖尿病的高度影响， 高血压、血脂异常、心血管疾病、中风、非酒精性脂肪肝和肥胖症， 以及与移民创伤有关的诊断不足的心理健康状况和心理社会问题， 歧视和边缘化。然而，关于单个阿萨组的流行病学数据很少， 大多数临床指南和治疗是基于来自高加索人的数据。我们的UG 3/UH 3研究中心 将与协调中心（U24）、其他研究中心和NHLBI合作， 10，000名成员，以描述各个阿萨A种族群体的风险因素和疾病模式。具体 拟议研究的目的是：1）促进制定研究的共同议定书， 与NHLBI，U24和其他UG 3/UH 3研究人员合作，建立最先进的人口组学 队列; 2）测量基线自我报告的健康和风险因素的患病率或分布，以及临床 每个种族群体中的标记物，并在种族群体之间进行比较;以及3）确定 每个阿萨种族组的基线风险因素，包括自我报告的压力和睡眠以及心率 来自可穿戴生物传感数据的可变性衍生的睡眠质量和压力，以及随后的（事件）健康 在后续的结果。这项拟议的研究是创新的，在其深入的麻烦组表型，通过 全面的调查，除了传统的风险外，还包括对幸福感和焦虑的评估 因素，基线临床评估，先进的数字技术和综合组学，以了解 流行病学、生物学、心理学和技术在身心健康方面的交叉点。我们将 利用这些创新以及斯坦福大学在人口健康科学方面的世界级资源， 揭示关键的心脏代谢和心理社会因素的健康和疾病的基础。本研究 将促进健康和疾病的预防和治疗，并将改善健康和福祉 AsA的结果。 1

Project Summary We propose to contribute a Bay Area, population-based prospective cohort to a nationwide cohort study of Asian American (AsA) men and women to address major gaps in evidence on the correlates and determinants of disease risk and health. We will recruit, characterize, and follow Chinese, Filipino, and Vietnamese Americans, three understudied AsA ethnic groups whose populations are rapidly expanding in the United States. Specifically, we will recruit 2,100 Chinese, Filipino, and Vietnamese Americans (700 of each ethnic group) in the San Francisco Bay Area to characterize cardiometabolic profiles and psychosocial and other health factors through extensive surveys, clinical assessments and assays, imaging studies, multi-omics, and digital technology. Although disease patterns and risk factors appear to vary among different AsA groups, previous research suggests that AsAs are highly affected by cardiometabolic disorders such as diabetes, hypertension, dyslipidemia, cardiovascular disease, stroke, non-alcoholic fatty liver disease, and obesity, as well as underdiagnosed mental health conditions and psychosocial issues related to immigration trauma, discrimination, and marginalization. However, epidemiological data on individual AsA groups are sparse, and most clinical guidelines and treatments are based on data derived from Caucasians. Our UG3/UH3 study site will collaborate with the Coordinating Center (U24), other study sites, and NHLBI to develop a large cohort of 10,000 members to characterize risk factors and disease patterns in individual AsA ethnic groups. The specific aims of the proposed study are to 1) contribute to the development of a Common Protocol for the study in collaboration with NHLBI, U24, and other UG3/UH3 investigators and establish a state-of-the-art populomics cohort; 2) measure the prevalence or distribution of baseline self-reported health and risk factors and clinical markers in each ethnic group and compare across ethnic groups; and 3) determine relationships among baseline risk factors in each AsA ethnic group, including self-reported stress and sleep as well as heart rate variability-derived sleep quality and stress from wearable biosensing data, with subsequent (incident) health outcomes during follow-up. This proposed study is innovative in its in-depth exposome phenotyping through comprehensive surveys that will include assessments of well-being and anxiety in addition to traditional risk factors, baseline clinical assessments, advanced digital technology, and integrative omics to understand the intersections of epidemiology, biology, psychology, and technology in physical and mental health. We will leverage these innovations alongside Stanford’s world-class resources in population health sciences to uncover critical cardiometabolic and psychosocial factors underlying health and disease in AsAs. This study will advance health and disease prevention and treatment and will lead to improved health and well-being outcomes for AsAs. 1