Evaluation of radon progeny and air pollution effects in asthma

评估氡子体和空气污染对哮喘的影响

基本信息

批准号：
10723709
负责人：
Tina Banzon
金额：
$ 20.75万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-11 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10723709
关键词：
Absenteeism Affect Air Pollutants Air Pollution Allergens Allergic Disease Asthma Award Biological Biological Markers Child Child Health Childhood Childhood Asthma Chronic Disease Chronic Obstructive Pulmonary Disease Clinical Investigator Clinical Trials Collaborations Data Data Reporting Development Diagnosis Educational Activities Enrollment Environment Environmental Epidemiology Environmental Exposure Environmental Risk Factor Epidemiology Evaluation Exhalation Exposure to FGF2 gene Funding Gases Goals Health Hospitalization IL8 gene Indoor Air Pollution Inflammation Inflammatory Infrastructure Inhalation Institution Interleukin-6 Intervention Intervention Studies Intervention Trial Learning Link Longitudinal Studies Lung Malignant neoplasm of lung Measures Mentors Modeling Morbidity - disease rate Nitric Oxide Obstructive Lung Diseases Outcome Outcomes Research Oxidative Stress Participant Particulate Matter Patients Peer Review Persons Phenotype Physical assessment Physical environment Planet Earth Policies Population Protocols documentation Public Health Schools Public Policy Publications Radiation Radioactive Radioactivity Radioisotopes Radon Regulation Research Research Personnel Research Project Grants Resources Respiratory System Risk Risk Factors Role Sampling School-Age Population Schools Serum Shapes Students Symptoms Testing Time Training United States United States National Institutes of Health Universities Uranium air cleaner airway inflammation asthma exacerbation biomarker identification carcinogenicity career career development catalyst cell injury clinical investigation cohort design disability elementary school fine particles health care service utilization high efficiency particulate air filter improved indoor allergen indoor exposure indoor pollutant inner city modifiable risk mortality novel parent grant particle particle exposure pollutant predictive modeling programs public health intervention pulmonary function remediation response skills spatiotemporal

项目摘要

PROJECT SUMMARY/ABSTRACT Research: Children exposed to indoor air pollution are known to more likely develop asthma, and in those with asthma, indoor air pollution can worsen asthma symptoms. Radon (Rn), a radioactive gas known for its lung cancer effects, decays into radiation-emitting progeny which has potential to induce cellular damage once inhaled. While residential Rn exposure is common, less is known about the non-cancer health effects of Rn decay products. Current health regulations and priorities are based solely on its carcinogenic effects in the lung. Indoor exposure to radon has been recently associated with COPD morbidity and mortality and an increased risk for hospital admissions. Given the association linking residential Rn exposure to COPD morbidity, in this exploratory application, we propose adverse health effects associated with Rn decay products via particle radioactivity in asthma morbidity, a common condition of obstructive lung disease in the pediatric population. Candidate: Dr. Banzon’s long-term goal is to become an independent NIH-funded investigator focused on the role of assessing the physical environment with a specific focus on air pollution and asthma morbidity in inner- city children. This proposal details a five-year project to provide Dr. Banzon the training and expertise necessary to study the effects of radon progeny and particle radioactivity in asthma by measuring its health effects in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). Her aim is to identify a novel and modifiable environmental exposure that contributes to asthma morbidity in children. The findings have potential to aid in the design of public health intervention trials, directly inform activities regarding radon mitigation as an intervention to alleviate disability from asthma, and identify biomarkers associated with particle radioactivity which may help phenotype patients and help predict those who may have a more favorable response to personalized asthma treatment based on biomarkers. Environment: Dr. Banzon will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. She has assembled an extraordinary team of advisors, including Drs. Petros Koutrakis, Jonathan Gaffin, and Brett Coull, who have committed their time, resources, and expertise to facilitate Dr. Banzon’s career development and successful completion of the proposed project. During this award period, Dr. Banzon will complete complementary coursework through the Harvard School of Public Health and Harvard Catalyst Program, with a focus to hone on her skills in environmental epidemiology targeted toward air pollution and childhood asthma. The academic environment created by the mentor, institution, Harvard University, and its affiliates provides fertile ground for learning and collaborating specific to her research. Dr. Banzon will emerge an expert in the field of environmental epidemiology, with a unique understanding of the physical environmental that will shape her into a successful independent investigator.

项目摘要/摘要研究：众所周知，暴露于室内空气污染的儿童更有可能发展哮喘哮喘，室内空气污染可能会恶化哮喘症状。 ra（RN），一种以肺而闻名的放射性气体癌症的影响，发射辐射进展，有可能诱导细胞损伤吸入。虽然居民RN暴露很常见，但对RN的非癌症健康影响的了解较少衰减产品。当前的健康法规和优先级仅基于其在肺中的致癌作用。室内暴露于ra的情况最近与COPD发病率和死亡率有关，并增加住院的风险。考虑到将居民接触到COPD发病率的关联，探索性应用，我们提出与RN衰减产物相关的不良健康影响哮喘发病率的放射性，这是小儿种群阻塞性肺部疾病的常见状况。候选人：Banzon博士的长期目标是成为一名独立的NIH资助的调查员评估物理环境的作用，特定着重于空气污染和哮喘发病率城市儿童。该建议详细介绍了一个为期五年的项目，以向Banzon博士提供必要的培训和专业知识通过测量其在哮喘中的影响，研究辐射进展的影响成立了哮喘的内城儿童参加了学校内城哮喘研究（PI： Phipatanakul）。她的目的是确定一种新颖且可修改的环境暴露，有助于哮喘儿童发病。这些发现有可能帮助设计公共卫生干预试验，直接告知有关缓解辐射的活动，以减轻哮喘的残疾，并确定与颗粒放射性相关的生物标志物，这可能有助于表型患者，并有助于预测可能对基于生物标志物的个性化哮喘治疗的反应更有利。环境：Banzon博士将由流行病学，临床试验专家Phipatanakul博士考虑哮喘和过敏性疾病的临床投资。她组建了一个非凡的顾问团队，包括Drs。 Petros Koutrakis，Jonathan Gaffin和Brett Coull，他们都投入了时间，资源，和专业知识，以促进Banzon博士的职业发展并成功完成该项目。在此颁奖期间，Banzon博士将通过哈佛学校完成完成课程公共卫生和哈佛催化剂计划，重点是磨练她在环境流行病学方面的技能针对空气污染和童年哮喘。精神，机构创造的学术环境，哈佛大学及其分支机构为学习和协作的研究提供了肥沃的基础。 Banzon博士将成为环境流行病学领域的专家，对物理环境将使她成为成功的独立研究者。