Vermont Center for Cardiovascular and Brain Health

佛蒙特州心血管和脑健康中心

• 批准号: 10724871
• 负责人: MARY CUSHMAN
• 金额: $ 27.24万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724871
• 关键词: Address; American; American Heart Association; Area; Basic Science; Brain Diseases; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Core Facility; Dementia; Development; Dimensions; Discipline; Disease; Disparate; Education; Electrophysiology (science); Epidemiology; Ethnic Origin; Evaluation; Evolution; Faculty; Fostering; Funding; Future; Gender; Goals; Grant; Heart Diseases; Hematological Disease; Image; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; Mentors; Mentorship; Microvascular Dysfunction; Molecular Epidemiology; Myocardial Infarction; Organ; Persons; Phase; Physiology; Process; Program Development; Race; Research; Research Design; Research Institute; Research Personnel; Research Support; Resources; Role; Science; Scientist; Stroke; Teacher Professional Development; Training; United States; United States National Institutes of Health; Universities; Vermont; Whole Organism; Work; brain health; cardiovascular health; career; clinical epidemiology; cognitive function; college; cost; disability; early-career faculty; experience; improved; innovation; instrumentation; meetings; member; mortality; multidisciplinary; neurovascular; next generation; novel; optimal treatments; peer coaching; programs; recruit; skills; success; supportive environment; symposium; synergism; vascular cognitive impairment and dementia

PROJECT SUMMARY Cardiovascular disease is the #1 cause of mortality in the United States and stroke is the #5 cause. Stroke is also the #1 cause of disability, and it, along with covert neurovascular disease including small vessel disease of the brain, leads to Vascular Cognitive Impairment and Dementia (VCID). Each year 800,000 Americans have a stroke and 720,000 Americans have myocardial infarction. There will be 75 million people with dementia by 2030 and 131 million by 2050. Direct annual costs of cardiovascular disease and stroke are $318 billion and dementia $277 billion. The American Heart Association issued a Presidential Advisory in 2017 highlighting the central role of cardiovascular health to brain health and cognitive function. Much of VCID is driven by increases in covert stroke and small vessel disease of the brain, research areas of expertise for the PIs of this application. To address these issues, this University of Vermont (UVM) Center on Cardiovascular and Brain Health (VCCBH) will leverage NIH funding and institutional commitment to convene multidisciplinary researchers across career stages to determine causes and suggest optimal treatments for cardiovascular and neurovascular disease, including stroke and VCID. We have selected four junior faculty (Project Directors, PDs), from three departments and two UVM colleges, through a rigorous selection process. The VCCBH will support the PDs' transition to independence using a Strategic Mentoring Initiative (SMI), Faculty Development Program (FDP), and assistance and education from two new Core facilities. The SMI will employ multidisciplinary Mentor Teams, including Peer Mentors. The FDP will comprise several educational programs highlighted by an annual 2-Day Research Symposium, and an impactful Pilot Grant program (supported by institutional commitments) that will provide $200,000 to four interdisciplinary research teams of junior faculty. We will establish two new Core facilities: Study Design and Molecular Epidemiology, and Customized Physiology and Imaging. A pipeline of new project directors will be developed from a pool of 19 current candidates and five new junior faculty, who will be recruited with committed institutional support. Capstones of the Center will include continual quality evaluation, clear communication and commitment to diversity. By the completion of Phase I of funding, the Center will be on a strong path to sustainability in research excellence.

项目概要 心血管疾病是美国第一大死因，中风是第五大死因。行程是 也是导致残疾的第一大原因，它与隐性神经血管疾病（包括小血管疾病）一起 大脑的损伤，导致血管性认知障碍和痴呆（VCID）。每年有 80 万美国人 中风和 720,000 美国人患有心肌梗塞。到那时将有 7500 万人患有痴呆症 2030 年，到 2050 年将达到 1.31 亿。心血管疾病和中风的每年直接费用为 3,180 亿美元， 痴呆症价值 2770 亿美元。美国心脏协会于 2017 年发布了一份总统建议，强调 心血管健康对大脑健康和认知功能的核心作用。 VCID 的大部分是由增长推动的 在隐性中风和大脑小血管疾病方面，该领域 PI 的专业研究领域 应用。为了解决这些问题，佛蒙特大学 (UVM) 心血管和大脑中心 卫生部门 (VCCBH) 将利用 NIH 的资金和机构承诺来召集多学科专家 研究人员在整个职业生涯阶段确定原因并提出心血管和疾病的最佳治疗方法 神经血管疾病，包括中风和 VCID。我们选拔了四名初级教师（项目总监、 PD），来自三个系和两所 UVM 学院，经过严格的选拔过程。 VCCBH 将 使用战略指导计划 (SMI)、教师发展支持 PD 向独立过渡 计划（FDP），以及两个新核心设施的援助和教育。 SMI 将聘用 多学科导师团队，包括同行导师。 FDP 将包括多个教育项目 年度为期 2 天的研究研讨会和有影响力的试点资助计划（由 机构承诺）将为四个由初级教师组成的跨学科研究团队提供 20 万美元。 我们将建立两个新的核心设施：研究设计和分子流行病学，以及定制 生理学和影像学。将从现有的 19 名项目总监中选拔新的项目总监。 候选人和五名新的初级教师，他们将在坚定的机构支持下招募。顶峰 该中心将包括持续的质量评估、清晰的沟通和对多样性的承诺。由 第一阶段资金完成后，该中心将走上卓越研究可持续发展的坚实道路。