Vermont Center for Cardiovascular and Brain Health

佛蒙特州心血管和脑健康中心

• 批准号: 10724871
• 负责人: MARY CUSHMAN
• 金额: $ 27.24万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724871
• 关键词: Address; American; American Heart Association; Area; Basic Science; Brain Diseases; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Core Facility; Dementia; Development; Dimensions; Discipline; Disease; Disparate; Education; Electrophysiology (science); Epidemiology; Ethnic Origin; Evaluation; Evolution; Faculty; Fostering; Funding; Future; Gender; Goals; Grant; Heart Diseases; Hematological Disease; Image; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; Mentors; Mentorship; Microvascular Dysfunction; Molecular Epidemiology; Myocardial Infarction; Organ; Persons; Phase; Physiology; Process; Program Development; Race; Research; Research Design; Research Institute; Research Personnel; Research Support; Resources; Role; Science; Scientist; Stroke; Teacher Professional Development; Training; United States; United States National Institutes of Health; Universities; Vermont; Whole Organism; Work; brain health; cardiovascular health; career; clinical epidemiology; cognitive function; college; cost; disability; early-career faculty; experience; improved; innovation; instrumentation; meetings; member; mortality; multidisciplinary; neurovascular; next generation; novel; optimal treatments; peer coaching; programs; recruit; skills; success; supportive environment; symposium; synergism; vascular cognitive impairment and dementia

PROJECT SUMMARY Cardiovascular disease is the #1 cause of mortality in the United States and stroke is the #5 cause. Stroke is also the #1 cause of disability, and it, along with covert neurovascular disease including small vessel disease of the brain, leads to Vascular Cognitive Impairment and Dementia (VCID). Each year 800,000 Americans have a stroke and 720,000 Americans have myocardial infarction. There will be 75 million people with dementia by 2030 and 131 million by 2050. Direct annual costs of cardiovascular disease and stroke are $318 billion and dementia $277 billion. The American Heart Association issued a Presidential Advisory in 2017 highlighting the central role of cardiovascular health to brain health and cognitive function. Much of VCID is driven by increases in covert stroke and small vessel disease of the brain, research areas of expertise for the PIs of this application. To address these issues, this University of Vermont (UVM) Center on Cardiovascular and Brain Health (VCCBH) will leverage NIH funding and institutional commitment to convene multidisciplinary researchers across career stages to determine causes and suggest optimal treatments for cardiovascular and neurovascular disease, including stroke and VCID. We have selected four junior faculty (Project Directors, PDs), from three departments and two UVM colleges, through a rigorous selection process. The VCCBH will support the PDs' transition to independence using a Strategic Mentoring Initiative (SMI), Faculty Development Program (FDP), and assistance and education from two new Core facilities. The SMI will employ multidisciplinary Mentor Teams, including Peer Mentors. The FDP will comprise several educational programs highlighted by an annual 2-Day Research Symposium, and an impactful Pilot Grant program (supported by institutional commitments) that will provide $200,000 to four interdisciplinary research teams of junior faculty. We will establish two new Core facilities: Study Design and Molecular Epidemiology, and Customized Physiology and Imaging. A pipeline of new project directors will be developed from a pool of 19 current candidates and five new junior faculty, who will be recruited with committed institutional support. Capstones of the Center will include continual quality evaluation, clear communication and commitment to diversity. By the completion of Phase I of funding, the Center will be on a strong path to sustainability in research excellence.

项目总结