A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI

个性化数字冥想对改善 MCI 认知和睡眠以及减轻压力影响的初步研究

• 批准号: 10726054
• 负责人: Christine Mairead Walsh
• 金额: $ 52.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10726054
• 关键词: Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Attention; Biological Markers; Blood; Brain; Clinical Markers; Cognition; Cognitive; Cognitive deficits; Cognitive remediation; Controlled Clinical Trials; Coupled; Data; Dementia; Diagnosis; Elderly; Exhibits; Foundations; Future; Goals; Home; Impaired cognition; Individual; Intervention; Length; Measures; Meditation; Monitor; Outcome Measure; Participant; Patients; Pattern; Personal Satisfaction; Physiological; Pilot Projects; Population; Randomized, Controlled Trials; Reaction Time; Regulation; Reporting; Research; Retrospective Studies; Risk; Risk Factors; Sampling; Severities; Sleep; Sleep disturbances; Sleeplessness; Stage III Sleep; Stress; Subgroup; Testing; Therapeutic; Thinness; Time; Work; cognitive ability; cognitive reserve; cognitive task; cohort; digital; efficacy evaluation; functional decline; improved; improvement on sleep; indexing; magnetic resonance imaging/electroencephalography; mild cognitive impairment; neuroimaging; neuropathology; non rapid eye movement; normal aging; novel; pre-clinical; prevent; progression risk; sleep onset; sleep quality; stress reactivity; stress reduction; telomere; tool; young adult

Abstract The overall goal of this project is to collect pilot data to determine if treatment with a novel form of closed-loop digital meditation (MediTrain), which we have previously shown improves cognition and reduces stress in older adults (OA), also leads to sleep benefits in both cognitively normal OA and in those with mild cognitive impairment (MCI). MCI is a transitional stage between normal aging and dementia and is associated with increased risk of progressing to Alzheimer’s disease and related dementias (ADRD). We have demonstrated that a digital meditation intervention (MediTrain) improves regulation of focused attention in healthy OA. Variability in attention is a preclinical marker of incipient neuropathology and is elevated in MCI patients. In addition to exhibiting decreased stress reactivity and a lengthening of telomeres, there were several anecdotal reports from OA that they felt their sleep had improved. Because sleep disturbances are common in AD and significantly increase the risk of conversion from MCI to dementia, understanding if this intervention led to improved sleep is critical. The goal of this proposed research is to collect pilot data to evaluate the efficacy of MediTrain on improving quantitative metrics of sleep and stress in patients with MCI at levels beyond those seen in cognitively normal OA. To accomplish these aims, we will conduct a randomized controlled trial on 90 OA (45 cognitively normal and 45 with MCI) who will complete 6 weeks of our MediTrain intervention. Outcome measures will consist of cognitive/attention tasks coupled with neuroimaging (EEG and MRI), quantitative physiological indices of sleep and stress, and blood biomarkers of aging (telomere length). Objective measures of insomnia (latency to sleep onset and wake after sleep onset) and amount of NREM3 will be assessed using sleep profilers in participants’ homes throughout the intervention period. This research will provide an important contribution toward understanding the utility of using meditation as a therapeutic tool for bolstering cognitive reserve and increasing overall wellbeing in OA with MCI, by showing transfer to real-world metrics of improved sleep quality and reduced stress.

摘要 该项目的总体目标是收集试验数据，以确定是否使用一种新形式的 闭环数字冥想（MediTrain），我们之前已经证明可以改善认知， 减少老年人（OA）的压力，也导致认知正常OA和 轻度认知障碍（MCI）患者。MCI是正常衰老和 痴呆症，并与进展为阿尔茨海默病和相关疾病的风险增加有关。 痴呆症（ADRD）。我们已经证明，数字冥想干预（MediTrain）可以改善 调节健康OA的集中注意力。注意力的变异性是一个早期的临床前标志 神经病理学，并且在轻度认知障碍患者中升高。除了表现出降低的应激反应性 和端粒的延长，有几个来自OA的轶事报告说，他们感觉到他们的睡眠 已经有所改善。因为睡眠障碍在AD中很常见，并且显著增加了 从MCI到痴呆症的转变，了解这种干预是否会改善睡眠至关重要。 这项拟议研究的目标是收集试点数据，以评估MediTrain对 改善MCI患者的睡眠和压力的定量指标， 认知正常的OA为了实现这些目标，我们将进行一项随机对照试验， OA患者（45名认知正常，45名MCI患者）将完成为期6周的MediTrain干预。 结果测量将包括认知/注意力任务与神经成像（EEG和MRI）， 睡眠和压力的定量生理指标，以及衰老的血液生物标志物（端粒长度）。 失眠的客观测量（入睡的潜伏期和入睡后的觉醒）和失眠的量。 在整个干预期间，将在参与者家中使用睡眠分析仪评估NREM 3。 这项研究将为理解冥想的效用做出重要贡献 作为支持认知储备和增加OA伴MCI患者整体健康的治疗工具， 通过显示转移到改善睡眠质量和减少压力的真实世界指标。