1 mm resolution single-photon spectral imaging of the brain

摘要： 在这项拟议的研究项目中，我们试图开发一种先进的脑SPECT系统，该系统提供 卓越的能量分辨率证明了独特的高光谱成像能力(例如，在140时为2.5keV) 能量范围宽(25-600 keV)，同时提供1-600 keV的 Mm空间分辨率和非常高的灵敏度，使多示踪剂摄取的详细可视化 不同的大脑区域。这一设备可能会对大脑研究产生革命性的影响，因为它允许 用于在各种实验条件下对大脑功能进行显微、多功能评估。 该研究项目将集成破坏性的高性能3D CZT成像光谱仪 采用新的合成复眼(SCE)相机设计的技术，以及创新的迭代 基于先验知识的深度学习图像重建方法，开发下一代临床脑 SPECT成像系统具有变革性的空间分辨率和成像灵敏度，是以往无法达到的。 长期目标是将这一创新的成像系统应用于人脑SPECT研究，使用 收集各种SPECT放射性示踪剂，开发和推进生理参数成像 方法论，以研究神经生物学中长期存在的问题，并改进我们的 对脑血流与脑组织、脑血流之间相互作用及关系的认识 不同认知挑战下的氧合作用、神经细胞代谢和脑细胞追踪 健康和疾病中的生物物理条件。我们设想拟议的系统将作为一个 独特的成像平台，显著提高了我们对神经细胞生物学和局部 大脑功能通过使用这些来响应各种认知、行为和生理挑战 前所未有的创新SPECT成像方法，以评估所有相关的定量 生理测量将以综合的方式和协同的方式进行解释，以便新的 大脑研究的前景是以前无法达到的，可以被阐明。

Abstract: In this proposed research project, we seek to develop an advanced brain SPECT system that offers a unique hyperspectral imaging capability substantiated by an excellent energy resolution (e.g., <2.5 keV at 140 keV and <3.5 keV at 250 keV) across a wide energy range (25-600 keV), and at the same time deliver a 1- mm spatial resolution and a very high sensitivity to allow detailed visualization of multi-tracer uptakes in various brain regions. This device could potentially have a transformative impact on brain research by allowing for microscopic, multi-functional assessment of brain functions under various experimental conditions. This proposed research project will integrate the disruptive high-performance 3D CZT imaging-spectrometer technologies with a novel synthetic compound eye (SCE) camera design, as well as an innovative iterative image reconstruction method using deep-learning based priors, to develop a next-generation clinical brain SPECT imaging system with transformative spatial resolution and imaging sensitivity unattainable previously. The long-term objective is to apply this innovative imaging system to human brain SPECT studies using a collection of various SPECT radiotracers, and develop and advance physiological parametric imaging methodologies, in order to investigate the long-standing issues in neurobiology and improve our understanding of the interplay and relationship among cerebral blood flow and perfusion, brain tissue oxygenation, neuronal cell metabolism, and brain cell tracking under different cognitive challenges and biophysical conditions in healthy and in disease. We would envision the proposed system to serve as a unique imaging platform to significantly advance our understanding of neural cell biology and regional brain functions in response to various cognitive, behavioral, and physiological challenges by employing these unprecedentedly innovative SPECT imaging methodologies in order to assess all relevant quantitative physiological measurements that will be interpreted in an integrated fashion and synergistically so that new perspectives in brain research unattainable previously can be formulated.