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An Ultra High Resolution MRI-Compatible SPECT System

超高分辨率 MRI 兼容 SPECT 系统

基本信息

批准号：
7622636
负责人：
LING-JIAN MENG
金额：
$ 15.07万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7622636
关键词：
Address Anodes Area Brain Brain Neoplasms Brain imaging Caliber Cathodes Charge Collection DCNU Development Due Process Electronics Electrons Evaluation Event Extravasation Figs - dietary Goals Head Hybrids I125 isotope Illinois Image Imaging Device Imaging Phantoms Immune response Immunotherapy Investigation Letters Magnetic Resonance Imaging Magnetism Mechanics Modality Modeling Mus Noise Operative Surgical Procedures Performance Photons Polychlorinated Biphenyls Positioning Attribute RF coil Research Research Design Resolution Sampling Scanning Semiconductors Signal Transduction Simulate Surface System T-Lymphocyte Technetium 99m Testing Thick Time Tracer Uncertainty Universities Work base bioimaging data acquisition design detector digital imaging detector imaging modality improved in vivo magnetic field mouse model novel prototype public health relevance research study response sensor single photon emission computed tomography tumor ultra high resolution

项目摘要

DESCRIPTION (provided by applicant): In this proposed investigation, we will develop a prototype very high resolution MR- compatible SPECT system that will be installed inside a pre-existing 4.7 Tesla Varian MRI scanner and allows for very high resolution, simultaneous mouse brain imaging using both SPECT and MRI modalities. This system is optimized for very-high resolution simultaneous SPECT and MR imaging study of mouse brain. It would substantially benefit the on-going research at UIUC for developing immunotherapy for brain tumors. This MR-compatible SPECT system is based on a very high resolution imaging sensor based on a novel energy resolved photon counting (ERPC) hybrid pixel sensor that we are currently developing. Multiple detector modules are used in a stationary ring configuration, which allows a sufficient angular sampling without moving the SPECT system. In this R21 project, the prototype MR-compatible SPECT system consists of three ERPC detector modules, fitted inside the 33cm diameter bore of the Varian MRI scanner. The major design goals of this system are to allow simultaneous data acquisition and to offer comparable imaging resolution (250-400um from SPECT and 100-200 from MRI) with both modalities. The use of the semiconductor detector allows the use of multiple tracers, such as Tc-99m, I-125 etc, at the same time, which further improve the versatility of this SPECT/MRI dual-modality imaging system. This proposed R21 effort will be focused on (a) develop a triple-headed SPECT system, (b) integration of the SPECT system with an existing 4.7T MRI system and (c) evaluate the prototype dual modality system for phantom imaging studies. In particular, substantial efforts will be dedicated to minimize the interferences between the simultaneously operated SPECT and MRI systems. This proposed R21 investigation will be concluded by a design study for a complete MR-compatible very-high resolution SPECT system. PUBLIC HEALTH RELEVANCE: The very-high resolution MR-compatible SPECT system will be dedicated to in vivo SPECT/MRI dual-modality imaging. It offers very-high resolution images simultaneous acquired with both SPECT and MRI, will is proven to be important for brain caner study using mouse models. This development will substantially benefit the on-going research at UIUC on developing immunotherapy for brain tumors.

描述（由申请人提供）：在本拟定研究中，我们将开发一种原型极高分辨率MR兼容SPECT系统，该系统将安装在预先存在的4.7 Tesla Varian MRI扫描仪内，并允许使用SPECT和MRI模态进行极高分辨率的同步小鼠脑成像。该系统是优化的非常高的分辨率同步SPECT和MR成像研究的小鼠大脑。这将大大有利于UIUC正在进行的研究，以开发脑肿瘤的免疫疗法。该MR兼容SPECT系统基于非常高分辨率的成像传感器，该成像传感器基于我们目前正在开发的新型能量分辨光子计数（ERPC）混合像素传感器。多个探测器模块用于固定环配置，这允许在不移动SPECT系统的情况下进行足够的角度采样。在该R21项目中，原型MR兼容SPECT系统由三个ERPC探测器模块组成，安装在Varian MRI扫描仪的33 cm直径孔内。该系统的主要设计目标是允许同时进行数据采集，并在两种模式下提供相当的成像分辨率（SPECT为250- 400 um，MRI为100-200 um）。半导体探测器的使用允许同时使用多种示踪剂，如Tc-99 m、I-125等，这进一步提高了该SPECT/MRI双模态成像系统的通用性。该拟议的R21工作将侧重于（a）开发三头SPECT系统，（B）SPECT系统与现有4.7 T MRI系统的集成，以及（c）评价用于体模成像研究的原型双模态系统。特别是，大量的努力将致力于最大限度地减少同时操作的SPECT和MRI系统之间的干扰。将通过对完整MR兼容超高分辨率SPECT系统的设计研究来结束本次拟定的R21研究。公共卫生相关性：超高分辨率MR兼容SPECT系统将专用于体内SPECT/MRI双模态成像。它提供了非常高的分辨率图像同时获得SPECT和MRI，将被证明是重要的脑癌研究使用小鼠模型。这一发展将大大有利于UIUC正在进行的关于开发脑肿瘤免疫疗法的研究。