Novel Implementation of Microporous Annealed Particle HydroGel for Next-generation Posterior Pharyngeal Wall Augmentation

合成水凝胶提供了一个很有前途的平台，用于增加呼吸消化系统的体积 精准医疗的方法。我们认为PPW的理想生物材料平台 增强治疗VPD将提供持久的组织膨胀效应，维持植入物 这是一种动态组织配置，并避免动态组织环境内的FBR。特别是微孔 退火粒子（MAP）水凝胶是微创治疗的理想材料平台， VPD的治疗这种新型生物材料是一项有前途的科学进步， 对改善唇腭裂和颅面疾病患者的VPD的影响， 与用于治疗VPD的咽壁增强相关。迫切需要利用 新的生物材料和微创方法，以改善长期结果， 管理和解决VPD。为了满足这一需求，我们开发了一种新的MAP迭代 优化用于肌肉植入的水凝胶，耐受动态运动，促进 出色的组织整合，并通过1：1体积置换提供持久的组织体积， 新生组织。在动物模型中应用这种独特的生物材料进行PPW加固 将允许MAP水凝胶的新分析和新的临床应用。这项建议 具体目的是（1）量化在兔模型中咽壁解剖结构的变化， 咽壁增强和（2）识别所需的宿主-植入物微环境， 在优化MAP凝胶咽壁填充后实现原位组织再生。

Synthetic hydrogels offer a promising platform for volumetric augmentation of the aerodigestive tract for precision medicine approaches. We propose that an ideal biomaterial platform for PPW augmentation to treat VPD would provide a durable tissue bulking effect, maintain implant configuration, and avoid FBR within a dynamic tissue environment. Specifically, Microporous Annealed Particle (MAP) hydrogels are an ideal material platform for the minimally invasive treatment of VPD. This novel biomaterial is a promising scientific advancement that has implications for improving VPD in patients with cleft and craniofacial conditions, particularly related to pharyngeal wall augmentation for managing VPD. There is a pressing need to utilize novel biomaterials and minimally invasive approaches to improve long-term outcomes for managing and resolving VPD. To address this need, we have developed a novel iteration of MAP hydrogel that is optimized for muscle implantation, tolerates dynamic movement, promotes excellent tissue integration, and provides persistent tissue bulk via 1:1 volume replacement with tissue de novo. Application of this unique biomaterial for PPW augmentation in an animal model will allow for novel analyses and new clinical applications for the MAP hydrogel. This proposal specifically aims to (1) quantify changes in pharyngeal wall anatomy in a rabbit model after pharyngeal wall augmentation and (2) identify the host-implant microenvironment required to achieve in situ tissue regeneration following optimized MAP gel pharyngeal wall augmentation.