Kansas Center for Metabolism and Obesity REsearch (KC-MORE)

整体中心：项目总结 科布雷的这项提议旨在建立堪萨斯代谢和肥胖研究中心(KC-MORE) 这将统一来自堪萨斯大学医学院多个部门和研究中心的研究人员 中心将重点研究肥胖、代谢功能障碍和肥胖相关疾病的病理。 肥胖是一个严重的问题，它正在损害堪萨斯州人民的健康，以及整个美国新的 需要研究驱动的解决方案和疗法来预防和治疗肥胖，研究新陈代谢 肥胖的信号，并检查肥胖引发慢性病的机制。KC- 更多将通过以下方式整合这些重点领域：(1)为肥胖相关的人创建一个共享的智力之家 通过共同的教育和研讨会计划，(2)为早期研究人员提供资金和指导 阶段肥胖相关研究人员建立独立的研究生涯，(3)建立科学核心，以 促进早期和成熟研究人员的翻译研究，以及(4)与 各部门联合招聘新的调查员到KUMC，重点关注KC-MORE的主题。这一核心角色 在领导和协调肥胖研究以及激励未来的资源和招聘方面，KUMC将允许 在肥胖、代谢和肥胖引发的问题上协同努力，形成多学科合作 如果没有科布雷的资助，疾病研究就不会发生。KC-MORE将由两名多- PIS，Steven Weinman博士和John Thyfaout博士，以及著名的高级调查员Joseph Donnelly博士 担任指导委员会主席，领导人体能量平衡研究。这些领导人有多个- 基础、临床和转化性研究方面的学科专业知识。该中心的第一阶段将 支持四个研究项目负责人(RPL)开展对能量的神经控制的研究 农村社区以临床为基础的平衡减肥方法和肥胖相关的基本机制 脂肪肝和高血压。KC-MORE还将管理一个试点奖励计划，以制定更多 KC-更多研究人员。KC-MORE将领导3个新的科学核心，为翻译 研究能力(代谢(MET)核心、细胞、组织、生物分析和生物信息学(CTBB)) 核心和人类能量平衡(HEB)核心)。这些核心将支持以下基础设施和方法 研究项目负责人、领航奖获得者和一大批与肥胖相关的既定群体 校园里的研究人员。KC-More Cobre第一阶段的关键目标将是帮助RPL开发 独立的、由R01资助的研究项目。总的来说，KC-MORE的成立将有助于发展 翻译和多学科肥胖研究计划，将在未来产生重大影响，通过 减轻肥胖相关疾病的负担。

CENTER OVERALL: PROJECT SUMMARY This COBRE proposal seeks to establish the Kansas Center for Metabolism and Obesity REsearch (KC-MORE) which will unify investigators from multiple departments and research centers at the University of Kansas Medical Center to focus research on the pathology of obesity, metabolic dysfunction, and obesity-related disease. Obesity is a critical problem that is harming the health of people in Kansas as well as the entire U.S. New research-driven solutions and therapies are needed to prevent and treat obesity, investigate metabolic signatures that underly obesity, and examine mechanisms by which obesity initiates chronic disease. The KC- MORE will serve to merge these areas of focus by (1) creating a shared intellectual home for obesity-related researchers through a common educational and seminar program, (2) providing funding and mentorship for early stage obesity-related investigators to establish independent research careers, (3) establishing scientific cores to facilitate translational research of both early stage and established investigators, and (4) partnering with departments to jointly recruit new investigators to KUMC focused on themes of the KC-MORE. This central role in leading and coordinating obesity research and incentivizing future resources and recruitment will allow KUMC to synergize efforts and form multi-disciplinary collaborations on obesity, metabolism, and obesity-induced disease research in ways that would not occur without COBRE funding. The KC-MORE will be led by two multi- PIs, Drs. Steven Weinman and John Thyfault, and a renowned senior investigator, Dr. Joseph Donnelly who will serve as Chair of the Steering Committee and lead human energy balance research. These leaders have multi- disciplinary but complimentary expertise in basic, clinical, and translational research. Phase 1 of the Center will support the development of four Research Project Leaders (RPLs) with studies on neural control of energy balance, clinical-based approaches to weight loss in rural communities, and basic mechanisms of obesity-related fatty liver disease and hypertension. KC-MORE will also administer a Pilot Awards Program to develop additional KC-MORE researchers. The KC-MORE will lead 3 new scientific cores that provide a foundation for translational research capabilities (the Metabolism (MET) core, the Cells, Tissues, Bioanalysis and Bioinformatics (CTBB) core, and the Human Energy Balance (HEB) core). The cores will support infrastructure and methodologies for the Research Project Leaders, the Pilot Award recipients, and a large pool of established obesity-related researchers on campus. A critical goal of phase 1 of the KC-MORE COBRE will be to help RPLs develop independent, R01-funded research programs. Overall, the establishment of the KC-MORE will serve to develop a translational and multi-disciplinary obesity research program that will have a significant future impact by reducing the burden of obesity-related disease conditions.