Kansas Center for Metabolism and Obesity REsearch (KC-MORE)

中心总体：项目总结 这项COBRE提案旨在建立堪萨斯代谢和肥胖研究中心（KC-MORE） 这将联合来自堪萨斯医科大学多个部门和研究中心的研究人员 中心的重点研究肥胖，代谢功能障碍和肥胖相关疾病的病理学。 肥胖是一个严重的问题，它正在危害堪萨斯乃至整个美国人民的健康。 需要研究驱动的解决方案和疗法来预防和治疗肥胖，研究代谢， 肥胖症的潜在特征，并研究肥胖症引发慢性疾病的机制。KC- MORE将通过以下方式合并这些重点领域：（1）为肥胖相关的 研究人员通过一个共同的教育和研讨会计划，（2）提供资金和导师的早期 阶段性肥胖相关研究者建立独立的研究事业，（3）建立科学核心， 促进早期和成熟研究者的转化研究，以及（4）与 各部门联合招聘新的调查员KUMC集中在KC-MORE的主题。这一核心作用 在领导和协调肥胖研究和激励未来的资源和招聘将使KUMC 协同努力，形成多学科的合作，对肥胖，代谢，和肥胖引起的 如果没有COBRE的资助，疾病研究就不会发生。KC-MORE将由两个多- PI，Steven Weinman博士和John Thyfault博士，以及著名的高级研究员Joseph Donnelly博士， 担任指导委员会主席，领导人类能量平衡研究。这些领导人有多种... 在基础、临床和转化研究方面的学科性但互补的专业知识。中心一期将 支持四个研究项目负责人（RPL）的发展，研究神经控制能量 平衡，农村社区基于临床的减肥方法，以及肥胖相关的基本机制 脂肪肝和高血压。KC-MORE还将管理试点奖励计划，以开发更多的 KC-MORE研究人员。KC-MORE将领导3个新的科学核心，为翻译提供基础 研究能力（代谢（MET）核心，细胞，组织，生物分析和生物信息学（CTBB）） 人类能量平衡（HEB）核心。这些核心将支持基础设施和方法， 研究项目负责人，试点奖获得者，以及大量与肥胖相关的 研究人员在校园里。KC-MORE COBRE第一阶段的一个关键目标是帮助RPL开发 独立的，R 01资助的研究项目。总的来说，KC-MORE的建立将有助于发展 一个转化和多学科的肥胖研究计划，将有一个重大的未来影响， 减轻肥胖相关疾病的负担。

CENTER OVERALL: PROJECT SUMMARY This COBRE proposal seeks to establish the Kansas Center for Metabolism and Obesity REsearch (KC-MORE) which will unify investigators from multiple departments and research centers at the University of Kansas Medical Center to focus research on the pathology of obesity, metabolic dysfunction, and obesity-related disease. Obesity is a critical problem that is harming the health of people in Kansas as well as the entire U.S. New research-driven solutions and therapies are needed to prevent and treat obesity, investigate metabolic signatures that underly obesity, and examine mechanisms by which obesity initiates chronic disease. The KC- MORE will serve to merge these areas of focus by (1) creating a shared intellectual home for obesity-related researchers through a common educational and seminar program, (2) providing funding and mentorship for early stage obesity-related investigators to establish independent research careers, (3) establishing scientific cores to facilitate translational research of both early stage and established investigators, and (4) partnering with departments to jointly recruit new investigators to KUMC focused on themes of the KC-MORE. This central role in leading and coordinating obesity research and incentivizing future resources and recruitment will allow KUMC to synergize efforts and form multi-disciplinary collaborations on obesity, metabolism, and obesity-induced disease research in ways that would not occur without COBRE funding. The KC-MORE will be led by two multi- PIs, Drs. Steven Weinman and John Thyfault, and a renowned senior investigator, Dr. Joseph Donnelly who will serve as Chair of the Steering Committee and lead human energy balance research. These leaders have multi- disciplinary but complimentary expertise in basic, clinical, and translational research. Phase 1 of the Center will support the development of four Research Project Leaders (RPLs) with studies on neural control of energy balance, clinical-based approaches to weight loss in rural communities, and basic mechanisms of obesity-related fatty liver disease and hypertension. KC-MORE will also administer a Pilot Awards Program to develop additional KC-MORE researchers. The KC-MORE will lead 3 new scientific cores that provide a foundation for translational research capabilities (the Metabolism (MET) core, the Cells, Tissues, Bioanalysis and Bioinformatics (CTBB) core, and the Human Energy Balance (HEB) core). The cores will support infrastructure and methodologies for the Research Project Leaders, the Pilot Award recipients, and a large pool of established obesity-related researchers on campus. A critical goal of phase 1 of the KC-MORE COBRE will be to help RPLs develop independent, R01-funded research programs. Overall, the establishment of the KC-MORE will serve to develop a translational and multi-disciplinary obesity research program that will have a significant future impact by reducing the burden of obesity-related disease conditions.