Translating Obesity, Metabolic Dysfunction and Comorbid Disease States

转化肥胖、代谢功能障碍和共存疾病状态

• 批准号: 10411630
• 负责人: John P Thyfault
• 金额: $ 10.55万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411630
• 关键词: Disease; Metabolic dysfunction; Obesity; Translating; comorbidity

PROJECT SUMMARY Obesity rates continue to rise in adolescents, adults, and aging populations leading to greater rates of chronic disease and comorbid disease conditions across the lifespan. Obesity and associated chronic disease conditions plague our healthcare system, negatively influence quality of life, and exact a terrible financial toll on society. Obesity induces pathologies that dramatically increase risk of metabolic disease states, cardiovascular dysfunction, chronic kidney disease, significant orthopedic limitations, and various forms of cancer. Obesity also increases risk for chronic debilitating pain conditions and mental health disorders (stress, depression, anxiety). Evidence over the last 3 decades shows that our current healthcare system is not effective in preventing or treating obesity and associated complications. Traditional methodologies have largely been ineffective because they have focused on single mode interventions (exercise, diet, pharmacology) or have not been effectively translated from the bench to the clinic or the clinic to population level. New research-driven solutions and therapies that bridge basic biomedical science, clinical, and population health research that are synergistically aligned and address the multi-modal constructs underlying obesity and co-morbid disease conditions are needed. Because obesity is central to so many diseases and comorbid conditions, and is increasingly prevalent, we argue that obesity should be a centerpiece in the training for the next generation of scientists. Our T32 proposal entitled “Translating Obesity, Metabolic Dysfunction and Comorbid Disease States” will provide foundational research training to predoctoral graduate students. The T32 training program will have 4 Pre- Doctoral trainees provided support for ~2 years and will strive to prepare trainees to work with divergent disciplines and foster synergistic and translational research teams. Trainees will be co-mentored by both basic science and clinical faculty and will interact with an internal advisory committee with basic, clinical, and translational scientific expertise. Trainees will take part in a unique training program involving both a diverse set of activities (seminars, meetings, didactic course work) and customized plans that meet the needs and goals of each trainee. The University of Kansas Medical Center (KUMC) has the necessary resources and scientific environment for this program including an established culture of translational researchers, a well-established community of federally funded investigators studying obesity and obesity associated comorbid disease conditions across the lifespan, synergy with the leading healthcare provider in the area (University of Kansas Health System), and access to a diverse population of research participants significantly impacted by obesity (urban, rural, various socioeconomic and ethnic groups). We expect that our T32 will provide unique training for predoctoral candidates, foster new collaborative research networks, and lead to new scientific discoveries for the treatment and prevention of obesity.

项目概要 青少年、成人和老年人口的肥胖率持续上升，导致肥胖率更高 整个生命周期的慢性疾病和合并症。肥胖和相关慢性疾病 这些状况困扰着我们的医疗保健系统，对生活质量产生负面影响，并对人们造成可怕的经济损失 社会。肥胖会诱发病理，显着增加代谢疾病、心血管疾病的风险 功能障碍、慢性肾病、严重的骨科限制和各种形式的癌症。肥胖也 增加慢性衰弱性疼痛和精神健康障碍（压力、抑郁、焦虑）的风险。 过去三十年的证据表明，我们当前的医疗保健系统并不能有效地预防或 治疗肥胖和相关并发症。传统的方法在很大程度上是无效的，因为 他们专注于单一模式的干预措施（运动、饮食、药理学），或者没有得到有效的治疗 从实验室到诊所或从诊所到人群水平。新的研究驱动的解决方案和 连接基础生物医学科学、临床和人口健康研究的协同疗法 协调并解决肥胖和共病疾病的多模式结构 需要。由于肥胖是许多疾病和合并症的核心，并且越来越普遍， 我们认为肥胖应该成为下一代科学家培训的核心内容。我们的T32 题为“转化肥胖、代谢功能障碍和共病疾病状态”的提案将提供 为博士前研究生提供基础研究培训。 T32培训计划将有4个Pre- 博士生提供了约 2 年的支持，并将努力帮助他们做好与不同领域工作的准备 学科并培养协同和转化研究团队。受训者将得到双方基础人员的共同指导 科学和临床教师，并将与内部咨询委员会互动，了解基础、临床和 转化科学专业知识。学员将参加一个独特的培训计划，涉及不同的群体 满足以下需求和目标的活动（研讨会、会议、教学课程）和定制计划 每个练习生。堪萨斯大学医学中心 (KUMC) 拥有必要的资源和科学 该计划的环境包括已建立的转化研究人员文化、完善的 由联邦资助的研究肥胖和肥胖相关合并症的研究人员组成的社区 整个生命周期的条件，与该地区领先的医疗保健提供者的协同作用（堪萨斯大学 卫生系统），以及接触受肥胖严重影响的不同研究参与者群体 （城市、农村、各种社会经济群体和种族群体）。我们期望我们的 T32 能够为以下人员提供独特的训练： 博士前候选人，培育新的合作研究网络，并带来新的科学发现 肥胖的治疗和预防。