Translating Obesity, Metabolic Dysfunction and Comorbid Disease States

转化肥胖、代谢功能障碍和共存疾病状态

• 批准号: 10411630
• 负责人: John P Thyfault
• 金额: $ 10.55万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411630
• 关键词: Disease; Metabolic dysfunction; Obesity; Translating; comorbidity

PROJECT SUMMARY Obesity rates continue to rise in adolescents, adults, and aging populations leading to greater rates of chronic disease and comorbid disease conditions across the lifespan. Obesity and associated chronic disease conditions plague our healthcare system, negatively influence quality of life, and exact a terrible financial toll on society. Obesity induces pathologies that dramatically increase risk of metabolic disease states, cardiovascular dysfunction, chronic kidney disease, significant orthopedic limitations, and various forms of cancer. Obesity also increases risk for chronic debilitating pain conditions and mental health disorders (stress, depression, anxiety). Evidence over the last 3 decades shows that our current healthcare system is not effective in preventing or treating obesity and associated complications. Traditional methodologies have largely been ineffective because they have focused on single mode interventions (exercise, diet, pharmacology) or have not been effectively translated from the bench to the clinic or the clinic to population level. New research-driven solutions and therapies that bridge basic biomedical science, clinical, and population health research that are synergistically aligned and address the multi-modal constructs underlying obesity and co-morbid disease conditions are needed. Because obesity is central to so many diseases and comorbid conditions, and is increasingly prevalent, we argue that obesity should be a centerpiece in the training for the next generation of scientists. Our T32 proposal entitled “Translating Obesity, Metabolic Dysfunction and Comorbid Disease States” will provide foundational research training to predoctoral graduate students. The T32 training program will have 4 Pre- Doctoral trainees provided support for ~2 years and will strive to prepare trainees to work with divergent disciplines and foster synergistic and translational research teams. Trainees will be co-mentored by both basic science and clinical faculty and will interact with an internal advisory committee with basic, clinical, and translational scientific expertise. Trainees will take part in a unique training program involving both a diverse set of activities (seminars, meetings, didactic course work) and customized plans that meet the needs and goals of each trainee. The University of Kansas Medical Center (KUMC) has the necessary resources and scientific environment for this program including an established culture of translational researchers, a well-established community of federally funded investigators studying obesity and obesity associated comorbid disease conditions across the lifespan, synergy with the leading healthcare provider in the area (University of Kansas Health System), and access to a diverse population of research participants significantly impacted by obesity (urban, rural, various socioeconomic and ethnic groups). We expect that our T32 will provide unique training for predoctoral candidates, foster new collaborative research networks, and lead to new scientific discoveries for the treatment and prevention of obesity.

项目总结 青少年、成年人和老龄化人口的肥胖率持续上升，导致 一生中的慢性病和并存疾病状况。肥胖与相关的慢性病 疾病困扰着我们的医疗保健系统，对生活质量产生负面影响，并对 社会。肥胖引起的病理显著增加了患代谢性疾病的风险，心血管疾病 功能障碍、慢性肾脏疾病、严重的整形外科限制，以及各种形式的癌症。肥胖症也是 增加慢性衰弱疼痛状况和精神健康障碍(压力、抑郁、焦虑)的风险。 过去30年的证据表明，我们目前的医疗体系在预防或 治疗肥胖症及相关并发症。传统的方法在很大程度上是无效的，因为 它们要么侧重于单一模式的干预(运动、饮食、药理学)，要么效果不佳。 从替补席到诊所或诊所到人口层面。以研究为导向的新解决方案和 将基础生物医学科学、临床和人群健康研究结合起来的疗法 调整和解决肥胖和共病疾病条件下的多模式结构 需要的。因为肥胖是许多疾病和共病的核心，而且越来越普遍， 我们认为，肥胖应该是下一代科学家培训的核心内容。我们的T32 题为“翻译肥胖、代谢功能障碍和共患疾病状态”的提案将提供 对博士后研究生进行基础研究培训。T32培训计划将有4个Pre 博士实习生提供了~2年的支持，并将努力为实习生与不同的工作做好准备 并培养协同研究和翻译研究团队。受训人员将由两个基本人员共同指导 科学和临床教职员工，并将与一个内部咨询委员会互动，包括基础、临床和 翻译科学专业知识。学员将参加一项独特的培训计划，包括不同的培训方案 满足以下需求和目标的活动(研讨会、会议、授课工作)和定制计划 每个实习生。堪萨斯大学医学中心(KUMC)拥有必要的资源和科学 该项目的环境包括已建立的翻译研究人员文化、成熟的 联邦政府资助的研究肥胖和肥胖相关共病的研究人员社区 整个生命周期的条件，与该地区领先的医疗保健提供者的协同作用(堪萨斯大学 卫生系统)，以及获得受肥胖严重影响的不同研究参与者的机会 (城市、农村、各种社会经济和族裔群体)。我们期待我们的T32将为以下人员提供独特的培训 博士前候选人，培养新的合作研究网络，并导致新的科学发现 肥胖症的治疗和预防。