Kansas Center for Metabolism and Obesity REsearch (KC-MORE)

堪萨斯代谢和肥胖研究中心 (KC-MORE)

• 批准号: 10598012
• 负责人: John P Thyfault
• 金额: $ 232万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598012
• 关键词: Acute Pain; Adolescent; Adult; Affect; Aging; Anxiety; Area; Award; Basic Science; Behavior; Bioenergetics; Bioinformatics; Blood; Body Weight decreased; COVID-19; Cells; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Collaborations; Communities; Development; Diabetes Mellitus; Disease; Eating; Education; Energy Metabolism; Foundations; Funding; Future; Goals; Growth; Health; Home; Human; Hypertension; Incidence; Infection; Infrastructure; Institution; Interdisciplinary Study; Internal Medicine; Isotopes; Kansas; Kidney Diseases; Lead; Link; Liver diseases; Longevity; Malignant Neoplasms; Measures; Medical center; Mental Depression; Mental disorders; Mentors; Mentorship; Metabolic; Metabolic dysfunction; Metabolism; Mitochondria; Modern 1601-history; Neurosciences; Obesity; Obesity Epidemic; Obesity associated disease; Outcome; Pathology; Persons; Phase; Physical activity; Physiology; Population; Population Heterogeneity; Predisposition; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Rodent; Rodent Model; Role; Rural Community; Series; Syndrome; Talents; Time; Tissues; Translational Research; United States National Institutes of Health; Universities; Weight; Work; body system; career; career development; chronic pain; combat; energy balance; faculty support; fatty liver disease; human subject; improved; metabolic phenotype; multidisciplinary; neuroregulation; next generation; nutrition; obese patients; obesity prevention; obesity treatment; precision medicine; prevent; programs; recruit; rural area; synergism; translational research program; urban area

CENTER OVERALL: PROJECT SUMMARY This COBRE proposal seeks to establish the Kansas Center for Metabolism and Obesity REsearch (KC-MORE) which will unify investigators from multiple departments and research centers at the University of Kansas Medical Center to focus research on the pathology of obesity, metabolic dysfunction, and obesity-related disease. Obesity is a critical problem that is harming the health of people in Kansas as well as the entire U.S. New research-driven solutions and therapies are needed to prevent and treat obesity, investigate metabolic signatures that underly obesity, and examine mechanisms by which obesity initiates chronic disease. The KC- MORE will serve to merge these areas of focus by (1) creating a shared intellectual home for obesity-related researchers through a common educational and seminar program, (2) providing funding and mentorship for early stage obesity-related investigators to establish independent research careers, (3) establishing scientific cores to facilitate translational research of both early stage and established investigators, and (4) partnering with departments to jointly recruit new investigators to KUMC focused on themes of the KC-MORE. This central role in leading and coordinating obesity research and incentivizing future resources and recruitment will allow KUMC to synergize efforts and form multi-disciplinary collaborations on obesity, metabolism, and obesity-induced disease research in ways that would not occur without COBRE funding. The KC-MORE will be led by two multi- PIs, Drs. Steven Weinman and John Thyfault, and a renowned senior investigator, Dr. Joseph Donnelly who will serve as Chair of the Steering Committee and lead human energy balance research. These leaders have multi- disciplinary but complimentary expertise in basic, clinical, and translational research. Phase 1 of the Center will support the development of four Research Project Leaders (RPLs) with studies on neural control of energy balance, clinical-based approaches to weight loss in rural communities, and basic mechanisms of obesity-related fatty liver disease and hypertension. KC-MORE will also administer a Pilot Awards Program to develop additional KC-MORE researchers. The KC-MORE will lead 3 new scientific cores that provide a foundation for translational research capabilities (the Metabolism (MET) core, the Cells, Tissues, Bioanalysis and Bioinformatics (CTBB) core, and the Human Energy Balance (HEB) core). The cores will support infrastructure and methodologies for the Research Project Leaders, the Pilot Award recipients, and a large pool of established obesity-related researchers on campus. A critical goal of phase 1 of the KC-MORE COBRE will be to help RPLs develop independent, R01-funded research programs. Overall, the establishment of the KC-MORE will serve to develop a translational and multi-disciplinary obesity research program that will have a significant future impact by reducing the burden of obesity-related disease conditions.

中心总体情况：项目摘要 该 COBRE 提案旨在建立堪萨斯代谢和肥胖研究中心 (KC-MORE) 这将联合堪萨斯大学医学院多个部门和研究中心的研究人员 该中心专注于肥胖病理学、代谢功能障碍和肥胖相关疾病的研究。 肥胖是危害堪萨斯州乃至整个美国人民健康的一个严重问题 需要研究驱动的解决方案和疗法来预防和治疗肥胖、研究代谢 肥胖的特征，并检查肥胖引发慢性疾病的机制。 KC- MORE 将通过以下方式融合这些重点领域：(1) 为肥胖相关问题创建一个共享的知识家园 研究人员通过共同的教育和研讨会计划，（2）为早期研究提供资金和指导 阶段肥胖相关研究人员建立独立的研究事业，（3）建立科学核心 促进早期和成熟研究人员的转化研究，以及（4）与 各部门联合招募新的调查员到 KUMC，重点关注 KC-MORE 的主题。这个核心角色 领导和协调肥胖研究并激励未来的资源和招聘将使 KUMC 在肥胖、代谢和肥胖引起的问题上协同努力并形成多学科合作 如果没有 COBRE 的资助，疾病研究就不会发生。 KC-MORE 将由两位多方领导 PI、博士。 Steven Weinman 和 John Thyfault，以及著名的高级研究员 Joseph Donnelly 博士，他将 担任指导委员会主席并领导人类能量平衡研究。这些领导人拥有多 基础、临床和转化研究方面的学科但互补的专业知识。该中心一期工程将 支持四名研究项目负责人（RPL）的发展，研究能量的神经控制 平衡、农村社区减肥的临床方法以及肥胖相关的基本机制 脂肪肝和高血压。 KC-MORE 还将管理试点奖励计划，以开发更多 KC-MORE 研究人员。 KC-MORE 将领导 3 个新的科学核心，为转化奠定基础 研究能力（代谢（MET）核心、细胞、组织、生物分析和生物信息学（CTBB） 核心、人体能量平衡 (HEB) 核心）。这些核心将支持基础设施和方法 研究项目负责人、试点奖获得者以及大量与肥胖相关的研究人员 校园里的研究人员。 KC-MORE COBRE 第一阶段的关键目标是帮助 RPL 发展 R01 资助的独立研究项目。总体而言，KC-MORE的成立将有助于发展 一项转化和多学科肥胖研究计划，将对未来产生重大影响 减轻肥胖相关疾病的负担。