Educational and Early Life Predictors of Mild Cognitive Impairment: New Evidence about Mediators and Moderators from High School & Beyond

项目摘要/摘要 我们建议对该奖项进行补充，以支持2021年高中及以后(HSB)的实地考察工作 将增加有关处方药历史的特殊行政记录。具体地说，我们将获得 关于所开药物的信息；准确的剂量；是否、何时和多久开一次处方 填写；处方遵从史；处方的名称、医疗专业和确切位置 医疗专业人员；处方的确切位置；以及可能的医疗状况(S) 医生开了药。 与我们的资助目标一致，拟议的补充活动将提供对 整个生命过程中的社会和生物过程如何调节早期生命的影响(特别是 教育)影响晚年生活认知功能的因素。从药房记录中获得的健康信息- 特别是关于身体和精神疾病的药物治疗的时机-将告知(A)我们 了解心脏代谢和其他生物途径如何塑造认知功能和(B)我们的 对HSB样本成员在2021年调查中测量的认知表现的解读。 具体地说，我们建议将HSB记录与同意的样本成员的药房记录联系起来(目标1)； 根据药房记录构建有用的总结措施(目标2)；记录结果总结 措施(目标3)；建立针对药房记录的抽样重量(目标4)；以及传播新的 测量、重量和文件编制(目标5)。所有拟议的补充活动将在 原五年期R01预算期结束。

PROJECT SUMMARY/ABSTRACT We propose a supplement to the award that supports the 2021 High School and Beyond (HSB) fieldwork that would add extraordinary administrative records about prescription drug histories. Specifically, we would obtain information about medications prescribed; exact dosages; whether, when, and how often prescriptions were filled; prescription compliance histories; the name, medical specialty, and exact location of the prescribing medical professional; exactly where prescriptions were filled; and the likely medical condition(s) for which medications were prescribed. Consistent with our funded Aims, the proposed supplemental activities will provide extraordinary insight into the ways in which social and biological processes across the life course mediate the effects of early life (especially educational) factors on later life cognitive functioning. Health information derived from pharmacy records— especially about the timing of pharmaceutical treatment for physical and mental conditions—will inform (a) our understanding of how cardiometabolic and other biological pathways shape cognitive functioning and (b) our interpretation of HSB sample members’ measured cognitive performance in the 2021 survey round. Specifically, we propose to link HSB records to pharmacy records for sample members who consented (Aim 1); construct useful summary measures from the pharmacy records (Aim 2); document the resulting summary measures (Aim 3); construct pharmacy record-specific sampling weights (Aim 4); and disseminate the new measures, weights, and documentation (Aim 5). All proposed supplemental activities would be completed by the end of the original five-year R01 budget period.