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Rural-Urban Differences in Polygenic Associations for Health and Health Behaviors

健康和健康行为多基因关联的城乡差异

基本信息

批准号：
10734666
负责人：
Jason D Boardman
金额：
$ 15.54万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734666
关键词：
Adolescent Adult Biological Biological Markers Cardiovascular system Cause of Death Characteristics Cholesterol Communities Complex Data Data Sources Diabetes Mellitus Diagnosis Dimensions Disparity Environment Epidemiologist Funding Genes Genetic Genetic Anticipation Genetic Polymorphism Genetic Predisposition to Disease Genetic Risk Genotype Health Health Disparities Research Health Policy Health and Retirement Study Health behavior Heritability Hypertension Individual Interdisciplinary Study Investments Life Cycle Stages Life Expectancy Life Style Link Literature Location Longitudinal Studies Measures Morbidity - disease rate National Longitudinal Survey of Adolescent to Adult Health Nature Obesity Outcome Pathway interactions Patient Self-Report Persons Phenotype Play Public Health Publishing R24 Research Research Personnel Respondent Risk Role Rural Rural Population Social Interaction Social Sciences Stress United States Woman Work aging population cardiovascular health cohort data resource food desert gene environment interaction genetic association genetic epidemiology genome-wide health care availability health care service utilization health data health disparity innovation insight interest men population health professional atmosphere rural area rural dwellers rural setting social social epidemiology symposium urban area urban disparity urban health disparities urban setting

项目摘要

PROJECT SUMMARY This project offers a different perspective on rural-urban health disparities by examining the potential role played by genetic predisposition toward cardiovascular health (CVH) risk. The findings from this work provide critical insight for population health policy given the importance of understanding the fundamental and complex origins of health challenges, be they social or biological, or a combination of both. We use five waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and build upon recent research that has demonstrated a clear urban cardiovascular health advantage across four measured and self-reported indicators of CVH: 1) Obesity; 2) High Cholesterol; 3) Hypertension; and 4) Diabetes. Our study examines rural-urban differences in the association between each of these measures of CVH and its corresponding polygenic score (PGS) which measures genetic predisposition toward each of the health outcomes. PGS values for three of these health outcomes already exist and we create PGS estimates for hypertension. This measure will be made available to Add Health users to fuel additional research on the intersections between social and genetic aspects of health disparities. Based on the small amount of research published on rural-urban disparities, we anticipate that genetic influences on CVH will be substantially lower among residents of rural areas compared to urban area residents. In doing so, this study will contribute to literatures in both social and genetic epidemiology related to rural-urban health disparities.

项目总结