Rural-Urban Differences in Polygenic Associations for Health and Health Behaviors

健康和健康行为多基因关联的城乡差异

基本信息

批准号：
10734666
负责人：
Jason D Boardman
金额：
$ 15.54万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734666
关键词：
Adolescent Adult Biological Biological Markers Cardiovascular system Cause of Death Characteristics Cholesterol Communities Complex Data Data Sources Diabetes Mellitus Diagnosis Dimensions Disparity Environment Epidemiologist Funding Genes Genetic Genetic Anticipation Genetic Polymorphism Genetic Predisposition to Disease Genetic Risk Genotype Health Health Disparities Research Health Policy Health and Retirement Study Health behavior Heritability Hypertension Individual Interdisciplinary Study Investments Life Cycle Stages Life Expectancy Life Style Link Literature Location Longitudinal Studies Measures Morbidity - disease rate National Longitudinal Survey of Adolescent to Adult Health Nature Obesity Outcome Pathway interactions Patient Self-Report Persons Phenotype Play Public Health Publishing R24 Research Research Personnel Respondent Risk Role Rural Rural Population Social Interaction Social Sciences Stress United States Woman Work aging population cardiovascular health cohort data resource food desert gene environment interaction genetic association genetic epidemiology genome-wide health care availability health care service utilization health data health disparity innovation insight interest men population health professional atmosphere rural area rural dwellers rural setting social social epidemiology symposium urban area urban disparity urban health disparities urban setting

项目摘要

PROJECT SUMMARY This project offers a different perspective on rural-urban health disparities by examining the potential role played by genetic predisposition toward cardiovascular health (CVH) risk. The findings from this work provide critical insight for population health policy given the importance of understanding the fundamental and complex origins of health challenges, be they social or biological, or a combination of both. We use five waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and build upon recent research that has demonstrated a clear urban cardiovascular health advantage across four measured and self-reported indicators of CVH: 1) Obesity; 2) High Cholesterol; 3) Hypertension; and 4) Diabetes. Our study examines rural-urban differences in the association between each of these measures of CVH and its corresponding polygenic score (PGS) which measures genetic predisposition toward each of the health outcomes. PGS values for three of these health outcomes already exist and we create PGS estimates for hypertension. This measure will be made available to Add Health users to fuel additional research on the intersections between social and genetic aspects of health disparities. Based on the small amount of research published on rural-urban disparities, we anticipate that genetic influences on CVH will be substantially lower among residents of rural areas compared to urban area residents. In doing so, this study will contribute to literatures in both social and genetic epidemiology related to rural-urban health disparities.

项目摘要该项目通过检查潜在的作用来对农村的城市健康差异提供不同的看法通过对心血管健康（CVH）风险的遗传倾向。这项工作的发现提供了关键鉴于了解基本和复杂起源的重要性，对人口健康政策的见识健康挑战，无论是社会还是生物学，还是两者的结合。我们使用了五个来自国家对成人健康的青少年纵向研究（增加健康），并以最新的研究为基础在四个测量和自我报告的指标中证明了明显的城市心血管健康优势 CVH：1）肥胖； 2）高胆固醇； 3）高血压；和4）糖尿病。我们的研究检查了农村城市 CVH的每个度量及其相应的多基因评分之间的关联差异（PG）测量对每个健康结果的遗传易感性。其中三个的PGS值健康结果已经存在，我们为高血压创建PGS估计。将采取此措施可用于增加健康用户，以推动有关社会和遗传方面之间相交的更多研究健康差异。根据关于农村城市差异的少量研究，我们预计与城市相比，农村地区居民对CVH的遗传影响将大大降低地区居民。在此过程中，这项研究将有助于社会和遗传流行病学相关的文献到城市健康差异。