Rural-Urban Differences in Polygenic Associations for Health and Health Behaviors

项目摘要 该项目通过研究农村与城市健康差距的潜在作用， 心血管健康（CVH）风险的遗传易感性。这项工作的结果提供了关键的 鉴于了解人口健康问题的根本和复杂根源的重要性， 健康挑战，无论是社会的还是生物的，或者两者兼而有之。我们使用了五波数据， 国家青少年成人健康纵向研究（添加健康），并建立在最近的研究， 在四个测量和自我报告的指标中，显示出明显的城市心血管健康优势 CVH：1）肥胖; 2）高胆固醇; 3）高血压;和4）糖尿病。我们的研究考察了农村-城市 CVH的这些指标中的每一个与其相应的多基因评分之间的关联差异 (PGS)它测量每种健康结果的遗传倾向。其中三个的PGS值 健康结果已经存在，我们创建了高血压的PGS估计值。这项措施将在 可供Add Health用户使用，以促进对社会和遗传方面之间交叉点的进一步研究 健康差距。基于对城乡差距发表的少量研究，我们预计 与城市居民相比，农村居民对CVH的遗传影响将大大降低 地区居民。在这样做的过程中，本研究将有助于社会和遗传流行病学相关的文献， 城乡健康差距。

PROJECT SUMMARY This project offers a different perspective on rural-urban health disparities by examining the potential role played by genetic predisposition toward cardiovascular health (CVH) risk. The findings from this work provide critical insight for population health policy given the importance of understanding the fundamental and complex origins of health challenges, be they social or biological, or a combination of both. We use five waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and build upon recent research that has demonstrated a clear urban cardiovascular health advantage across four measured and self-reported indicators of CVH: 1) Obesity; 2) High Cholesterol; 3) Hypertension; and 4) Diabetes. Our study examines rural-urban differences in the association between each of these measures of CVH and its corresponding polygenic score (PGS) which measures genetic predisposition toward each of the health outcomes. PGS values for three of these health outcomes already exist and we create PGS estimates for hypertension. This measure will be made available to Add Health users to fuel additional research on the intersections between social and genetic aspects of health disparities. Based on the small amount of research published on rural-urban disparities, we anticipate that genetic influences on CVH will be substantially lower among residents of rural areas compared to urban area residents. In doing so, this study will contribute to literatures in both social and genetic epidemiology related to rural-urban health disparities.