Rural-Urban Differences in Polygenic Associations for Health and Health Behaviors

健康和健康行为多基因关联的城乡差异

• 批准号: 10734666
• 负责人: Jason D Boardman
• 金额: $ 15.54万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734666
• 关键词: Adolescent; Adult; Biological; Biological Markers; Cardiovascular system; Cause of Death; Characteristics; Cholesterol; Communities; Complex; Data; Data Sources; Diabetes Mellitus; Diagnosis; Dimensions; Disparity; Environment; Epidemiologist; Funding; Genes; Genetic; Genetic Anticipation; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic Risk; Genotype; Health; Health Disparities Research; Health Policy; Health and Retirement Study; Health behavior; Heritability; Hypertension; Individual; Interdisciplinary Study; Investments; Life Cycle Stages; Life Expectancy; Life Style; Link; Literature; Location; Longitudinal Studies; Measures; Morbidity - disease rate; National Longitudinal Survey of Adolescent to Adult Health; Nature; Obesity; Outcome; Pathway interactions; Patient Self-Report; Persons; Phenotype; Play; Public Health; Publishing; R24; Research; Research Personnel; Respondent; Risk; Role; Rural; Rural Population; Social Interaction; Social Sciences; Stress; United States; Woman; Work; aging population; cardiovascular health; cohort; data resource; food desert; gene environment interaction; genetic association; genetic epidemiology; genome-wide; health care availability; health care service utilization; health data; health disparity; innovation; insight; interest; men; population health; professional atmosphere; rural area; rural dwellers; rural setting; social; social epidemiology; symposium; urban area; urban disparity; urban health disparities; urban setting

PROJECT SUMMARY This project offers a different perspective on rural-urban health disparities by examining the potential role played by genetic predisposition toward cardiovascular health (CVH) risk. The findings from this work provide critical insight for population health policy given the importance of understanding the fundamental and complex origins of health challenges, be they social or biological, or a combination of both. We use five waves of data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) and build upon recent research that has demonstrated a clear urban cardiovascular health advantage across four measured and self-reported indicators of CVH: 1) Obesity; 2) High Cholesterol; 3) Hypertension; and 4) Diabetes. Our study examines rural-urban differences in the association between each of these measures of CVH and its corresponding polygenic score (PGS) which measures genetic predisposition toward each of the health outcomes. PGS values for three of these health outcomes already exist and we create PGS estimates for hypertension. This measure will be made available to Add Health users to fuel additional research on the intersections between social and genetic aspects of health disparities. Based on the small amount of research published on rural-urban disparities, we anticipate that genetic influences on CVH will be substantially lower among residents of rural areas compared to urban area residents. In doing so, this study will contribute to literatures in both social and genetic epidemiology related to rural-urban health disparities.

项目概要 该项目通过研究所发挥的潜在作用，为城乡健康差异提供了不同的视角 心血管健康 (CVH) 风险的遗传倾向。这项工作的发现提供了重要的 鉴于了解基本和复杂起源的重要性，对人口健康政策的洞察力 健康挑战，无论是社会挑战还是生物挑战，或者两者兼而有之。我们使用来自 国家青少年至成人健康纵向研究（Add Health）并以最近的研究为基础 在四项测量和自我报告指标中表现出明显的城市心血管健康优势 CVH的影响： 1）肥胖； 2）高胆固醇； 3）高血压； 4) 糖尿病。我们的研究考察了城乡 这些 CVH 测量值与其相应的多基因评分之间的关​​联差异 （PGS）衡量每种健康结果的遗传倾向。其中三个的 PGS 值 健康结果已经存在，我们对高血压进行了 PGS 估计。将采取这一措施 可供 Add Health 用户推动对社会和遗传方面交叉点的进一步研究 健康差异。根据已发表的有关城乡差异的少量研究，我们预计 与城市居民相比，农村地区居民的遗传对 CVH 的影响要低得多 地区居民。在此过程中，本研究将为社会和遗传流行病学相关文献做出贡献 城乡健康差距。