A developmental biological analysis: Neurotropic effects of estrogen on the perinatal hypothalamic tissue transplanted into the adult rat brain.

发育生物学分析：雌激素对移植到成年大鼠大脑的围产期下丘脑组织的神经营养作用。

• 批准号: 61570031
• 负责人: ARAI Yasumasa
• 金额: $ 1.41万
• 依托单位: Juntendo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570031/
• 关键词: neonatal preoptic area; brain transplantation; third ventricle; estrogen; タロシン水酸化酵素; エストロゲン; 向神経作用; シナプス形成の促進; NGF; ガングリオシド; 脳の発達; シナプス形成

The preoptic area (POA) or cerebral cortex taken from newborn female rats was transplanted into the third ventricle of ovariectomized adult rats. From the day of transplantation, estradiol-17 in a Silastic tube was implanted subcutaneously into host animals for 4 weeks. The POA of cerebral cortes transplants were examined at light- and electron-microscopic levels 4 weeks after transplantation.Estrogen exposure for 4 weeks via the host induced a significant increase in the volume of the POA grafts. The number of axodendritic shaft and spine synapses was significantly greater in the grafts exposed to estrogen than that of the POA grafts without estrogen tratment. In contrast, there was no significant difference in the volume of conticat tissues transplanted into the brain between the control and estrogentreated grups.The results suggest that estrogen has a stimulatory effect on the development of neuronal substrates in the ntraventricular POA graft, increasing its volume and synaptic population.

将新生雌性大鼠视前区（POA）或大脑皮质移植到去卵巢成年大鼠的第三脑室。从移植之日起，将硅胶管中的雌二醇-17皮下植入宿主动物体内4周。移植后4周，在光镜和电镜水平上观察大脑科尔特斯移植物的POA，通过宿主暴露雌激素4周可诱导POA移植物体积显著增加。雌激素处理组的轴-树轴和棘突触数明显多于未处理组。结果表明，雌激素对侧脑室内POA移植物中神经元基质的发育有促进作用，增加了移植物的体积和突触数量。

项目成果

Ari,Y.: Current Topics in Neuroendocrinology. 7. 291-307 (1986)

Ari，Y.：神经内分泌学的当前主题。

Matsumoto,A.: Cell Tiss.Res.(1988)

Matsumoto,A.：细胞 Tiss.Res.(1988)

Ari,Y.: Monographs in Neural Sciences. 12. 64-68 (1986)

Ari，Y.：神经科学专着。

Satoshi Ito: Brain & Development. 8. 463-468 (1986)

伊藤聪：大脑

Miyakawa, M.; Arai, Y.: "Synaptic plasticity to estrogen in the lateral septum of the adult male and female rats." Brain Res.436. 184-188 (1987)

宫川，M.；