A developmental biological analysis: Neurotropic effects of estrogen on the perinatal hypothalamic tissue transplanted into the adult rat brain.

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The preoptic area (POA) or cerebral cortex taken from newborn female rats was transplanted into the third ventricle of ovariectomized adult rats. From the day of transplantation, estradiol-17 in a Silastic tube was implanted subcutaneously into host animals for 4 weeks. The POA of cerebral cortes transplants were examined at light- and electron-microscopic levels 4 weeks after transplantation.Estrogen exposure for 4 weeks via the host induced a significant increase in the volume of the POA grafts. The number of axodendritic shaft and spine synapses was significantly greater in the grafts exposed to estrogen than that of the POA grafts without estrogen tratment. In contrast, there was no significant difference in the volume of conticat tissues transplanted into the brain between the control and estrogentreated grups.The results suggest that estrogen has a stimulatory effect on the development of neuronal substrates in the ntraventricular POA graft, increasing its volume and synaptic population.