Advancing Research-Related Operations with Nonhuman Primate Caging and Enrichment

通过非人类灵长类动物笼养和富集推进与研究相关的操作

• 批准号: 10734488
• 负责人: Kelly Jean Hopper
• 金额: $ 34.76万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10734488
• 关键词: Achievement; Adolescent; Animal Experimentation; Animal Welfare Act; Animals; Award; Baltimore; Behavioral; Cardiac; Caring; Censuses; Complex; Data; Device or Instrument Development; Devices; Education; Environment; Equipment and supply inventories; Estrogens; Ethics; Family suidae; Fetal Development; Fetal Growth; Fetal Research; Food; Funding; Growth; Health; Heart; Home; Housing; Human; Investments; Maryland; Maternal-fetal medicine; Medical; Medical Device; Medicine; Mission; Modernization; Organ; Outcomes Research; Papio; Persons; Pharmaceutical Preparations; Physiological; Play; Productivity; Regulation; Research; Research Personnel; Resources; Role; Safety; Science; Services; Societies; Thumb structure; Transplantation; United States; United States National Institutes of Health; Universities; Vaccines; Water; Weaning; Work; Xenograft procedure; animal breeding; animal facility; animal resource; animal safety; clinical care; comparative; design; flexibility; guide for the care and use of laboratory animals; improved; medical schools; nonhuman primate; operation; professional atmosphere; programs; restraint; social; species typical behavior; welfare

PROJECT SUMMARY University of Maryland, Baltimore (UMB)'s mission is “To improve the human condition and serve the public good of Maryland and society at-large through education, research, clinical care, and service.” In FY 2021, the National Institutes of Health (NIH) awarded $234 million to UMB. In terms of funding received, the School of Medicine ranked 15th compared to other public schools of medicine and 29th overall. High profile research using baboons is part of UMB's research portfolio. Recently, cardiac xenotransplantation research at UMB resulted in a medical breakthrough where the heart of a genetically modified pig was transplanted into a human. This achievement was supported by work done with baboons within UMB's Program for Comparative Medicine and Veterinary Resources (VR) animal facilities. Xenotransplantation may soon be an option for the thousands of people in the United States waiting for transplants, many of whom will die before they receive an organ. Baboons are also used at UMB to study estrogen effects on fetal growth and development as part of a long-term research program in maternal-fetal medicine. As a larger, more sentient species with opposable thumbs, baboon caging, enrichment, welfare, and safety can be quite complex. The groundbreaking xenotransplantation research conducted at UMB is growing, and the need for more animals and new caging has increased. VR's current cage inventory is insufficient to support this growth. In the maternal-fetal research program, breeding animals must be co-housed, which requires flexible cage configurations, larger cages, and additional cages for weaned and juvenile baboons. All animals must be housed in cages of sufficient size to meet the requirements of the Animal Welfare Act Regulations (AWR) and The Guide For The Care And Use Of Laboratory Animals (The Guide). In addition to supporting our growing need for baboons and their housing, modern caging can provide the opportunity for additional enrichment options to improve the welfare and behavioral management of the animals while they are on study. Providing enrichment opportunities to promote species typical behaviors is also a regulatory requirement. Social species of nonhuman primates (NHP) must be housed with other animals unless single housing is justified. This requirement furthers the need for large cages and flexibility in cage configurations that is not consistent with and cannot be achieved with VR's current inventory of baboon cages. Modern caging is also designed with safety features for those who care for and work with these large NHPs. This improves human safety and promotes more productive research with enhanced abilities to safely restrain and manipulate animals in their home cage.

项目概要 马里兰大学巴尔的摩分校 (UMB) 的使命是“改善人类状况并服务 通过教育、研究、临床护理和 服务。” 2021 财年，美国国立卫生研究院 (NIH) 向 UMB 拨款 2.34 亿美元。在 就获得的资助而言，医学院在其他公立学校中排名第15 医学专业，总体排名第 29 位。使用狒狒进行的备受瞩目的研究是 UMB 研究的一部分 文件夹。最近，UMB 的心脏异种移植研究取得了医学成果 将转基因猪的心脏移植到人类身上的突破。这 这一成就得到了 UMB 比较计划中对狒狒所做的工作的支持 医学和兽医资源 (VR) 动物设施。异种移植可能很快就会成为一种 为美国数千名等待移植的人提供了选择，其中许多人将 在接受器官之前死亡。 UMB 还利用狒狒来研究雌激素对 胎儿生长和发育作为母胎医学长期研究计划的一部分。 作为一个体型更大、更有感知能力的物种，有对生拇指、狒狒关在笼子里、丰富、福利， 安全性可能相当复杂。开创性的异种移植研究 UMB 的规模正在不断扩大，对更多动物和新笼具的需求也在增加。 VR的现状 网箱库存不足以支持这种增长。在母胎研究计划中， 饲养动物必须共同饲养，这需要灵活的笼子配置、更大的笼子、 以及用于断奶和幼年狒狒的额外笼子。所有动物必须关在笼子里 足够的尺寸以满足《动物福利法条例》(AWR) 和《动物福利法》的要求 实验动物护理和使用指南（指南）。除了支持我们的 对狒狒及其住房的需求不断增长，现代笼养可以为狒狒提供机会 额外的丰富选项，以改善动物的福利和行为管理 当他们在学习的时候。提供丰富机会以促进物种典型行为 也是监管要求。必须安置非人类灵长类动物 (NHP) 的社会物种 与其他动物一起饲养，除非单一饲养是合理的。这一要求进一步推动了对大型 保持架和保持架配置的灵活性与以下不一致且无法实现 VR目前的狒狒笼子库存。现代笼子还设计有安全功能 那些关心这些大型 NHP 并与之合作的人。这提高了人类安全并促进 更富有成效的研究，增强安全约束和操纵动物的能力 他们家的笼子。