Advancing Research-Related Operations with Nonhuman Primate Caging and Enrichment

通过非人类灵长类动物笼养和富集推进与研究相关的操作

• 批准号: 10734488
• 负责人: Kelly Jean Hopper
• 金额: $ 34.76万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10734488
• 关键词: Achievement; Adolescent; Animal Experimentation; Animal Welfare Act; Animals; Award; Baltimore; Behavioral; Cardiac; Caring; Censuses; Complex; Data; Device or Instrument Development; Devices; Education; Environment; Equipment and supply inventories; Estrogens; Ethics; Family suidae; Fetal Development; Fetal Growth; Fetal Research; Food; Funding; Growth; Health; Heart; Home; Housing; Human; Investments; Maryland; Maternal-fetal medicine; Medical; Medical Device; Medicine; Mission; Modernization; Organ; Outcomes Research; Papio; Persons; Pharmaceutical Preparations; Physiological; Play; Productivity; Regulation; Research; Research Personnel; Resources; Role; Safety; Science; Services; Societies; Thumb structure; Transplantation; United States; United States National Institutes of Health; Universities; Vaccines; Water; Weaning; Work; Xenograft procedure; animal breeding; animal facility; animal resource; animal safety; clinical care; comparative; design; flexibility; guide for the care and use of laboratory animals; improved; medical schools; nonhuman primate; operation; professional atmosphere; programs; restraint; social; species typical behavior; welfare

PROJECT SUMMARY University of Maryland, Baltimore (UMB)'s mission is “To improve the human condition and serve the public good of Maryland and society at-large through education, research, clinical care, and service.” In FY 2021, the National Institutes of Health (NIH) awarded $234 million to UMB. In terms of funding received, the School of Medicine ranked 15th compared to other public schools of medicine and 29th overall. High profile research using baboons is part of UMB's research portfolio. Recently, cardiac xenotransplantation research at UMB resulted in a medical breakthrough where the heart of a genetically modified pig was transplanted into a human. This achievement was supported by work done with baboons within UMB's Program for Comparative Medicine and Veterinary Resources (VR) animal facilities. Xenotransplantation may soon be an option for the thousands of people in the United States waiting for transplants, many of whom will die before they receive an organ. Baboons are also used at UMB to study estrogen effects on fetal growth and development as part of a long-term research program in maternal-fetal medicine. As a larger, more sentient species with opposable thumbs, baboon caging, enrichment, welfare, and safety can be quite complex. The groundbreaking xenotransplantation research conducted at UMB is growing, and the need for more animals and new caging has increased. VR's current cage inventory is insufficient to support this growth. In the maternal-fetal research program, breeding animals must be co-housed, which requires flexible cage configurations, larger cages, and additional cages for weaned and juvenile baboons. All animals must be housed in cages of sufficient size to meet the requirements of the Animal Welfare Act Regulations (AWR) and The Guide For The Care And Use Of Laboratory Animals (The Guide). In addition to supporting our growing need for baboons and their housing, modern caging can provide the opportunity for additional enrichment options to improve the welfare and behavioral management of the animals while they are on study. Providing enrichment opportunities to promote species typical behaviors is also a regulatory requirement. Social species of nonhuman primates (NHP) must be housed with other animals unless single housing is justified. This requirement furthers the need for large cages and flexibility in cage configurations that is not consistent with and cannot be achieved with VR's current inventory of baboon cages. Modern caging is also designed with safety features for those who care for and work with these large NHPs. This improves human safety and promotes more productive research with enhanced abilities to safely restrain and manipulate animals in their home cage.

项目摘要 马里兰州，巴尔的摩（UMB）的大学的使命是“改善人类的条件和服务 马里兰州和整个社会通过教育，研究，临床护理， 服务。”2021财年，美国国立卫生研究院（NIH）向UMB拨款2. 34亿美元。在 就获得的资金而言，医学院与其他公立学校相比排名第15位。 第29名，总的来说。使用狒狒的高调研究是UMB研究的一部分 portfolio.最近，在UMB的心脏异种移植研究导致了一个医学 转基因猪的心脏被移植到人类身上。这 这一成就得到了UMB比较项目中狒狒工作的支持。 医学和兽医资源（VR）动物设施。异种移植可能很快就会成为一种 这是美国成千上万等待移植的人的选择，其中许多人将 在接受器官移植前就死了狒狒也在UMB用于研究雌激素对 胎儿生长和发育作为母胎医学长期研究计划的一部分。 作为一个更大，更有感知力的物种，狒狒有对生拇指，关在笼子里，丰富，福利， 和安全性是相当复杂的。开创性的异种移植研究 在UMB的数量正在增长，对更多动物和新笼子的需求也在增加。VR的当前 笼库存不足以支持这种增长。在母胎研究项目中， 繁殖动物必须共同圈养，这需要灵活的笼子结构，较大的笼子， 以及用于断奶和幼年狒狒的额外笼子。所有动物必须圈养在 足够的大小，以满足动物福利法法规（AWR）和 《实验动物护理和使用指南》（Guide For The Care And Use Of Laboratory Animals）除了支持我们的 对狒狒和它们的住房的需求不断增长，现代笼子可以提供机会， 额外的富集选择，以改善动物的福利和行为管理 在他们学习的时候。提供丰富的机会，促进物种的典型行为 这也是一个监管要求。非人类灵长类动物（NHP）的社会物种必须被圈养 与其他动物一起饲养，除非单独饲养是合理的。这一要求进一步需要大 融合器和融合器配置的灵活性与 虚拟现实目前的狒狒笼库存。现代笼舍还设计有安全功能， 那些照顾和与这些大型NHP一起工作的人。这提高了人类的安全性， 更富有成效的研究，增强安全地约束和操纵动物的能力， 他们的家笼子。