Advancing Research-Related Operations with Nonhuman Primate Caging and Enrichment

项目总结 马里兰大学巴尔的摩分校(UMB)S的使命是“改善人类生活条件，服务人类” 马里兰州和整个社会的公共利益通过教育、研究、临床护理和 服务。“在2021财年，美国国立卫生研究院(NIH)向UMB提供了2.34亿美元。在……里面 就收到的资金而言，医学院与其他公立学校相比排名第15 医学排行榜，排名第29位。UMB研究的一部分是高调使用狒狒进行的研究 公文包。最近，UMB的心脏异种移植研究导致了一项医学研究 将转基因猪的心脏移植到人类体内的突破。这 这一成就得到了UMB比较计划内对狒狒所做工作的支持 药物和兽医资源(VR)动物设施。异种移植可能很快成为一种 为美国成千上万等待移植的人提供选择，其中许多人将 在接受器官之前死亡。UMB也使用狒狒来研究雌激素对女性的影响 作为母胎医学长期研究计划的一部分，胎儿生长和发育。 作为一种体型更大、更有知觉的物种，具有对生的拇指、笼子、丰富、福利， 而且安全问题可能相当复杂。进行了开创性的异种移植研究 UMB的数量正在增加，对更多动物和新笼子的需求也增加了。虚拟现实的电流 网箱库存不足以支持这一增长。在母胎研究项目中， 繁殖的动物必须合住，这需要灵活的笼子配置，更大的笼子， 以及为断奶和幼崽提供额外的笼子。所有动物都必须被关在笼子里 足够的大小以满足动物福利法条例(AWR)和 《保护和使用实验动物指南》(《指南》)。除了支持我们的 对狒狒及其住房的需求不断增长，现代笼子可以为 为改善动物的福利和行为管理而提供的其他丰富选择 当他们在学习的时候。提供丰富机会，促进物种典型行为 也是一项监管要求。非人灵长类群居物种(NHP)必须被安置 与其他动物在一起，除非单独安置是合理的。这一要求进一步增加了对大型 与保持架配置不一致且不能实现的保持架和灵活性 VR目前的狒狒笼子库存。现代笼子还设计了安全功能，以 那些关心这些大型NHP并与其合作的人。这提高了人类的安全，并促进了 更有成效的研究，增强了安全控制和操纵动物的能力 他们家的笼子。

PROJECT SUMMARY University of Maryland, Baltimore (UMB)'s mission is “To improve the human condition and serve the public good of Maryland and society at-large through education, research, clinical care, and service.” In FY 2021, the National Institutes of Health (NIH) awarded $234 million to UMB. In terms of funding received, the School of Medicine ranked 15th compared to other public schools of medicine and 29th overall. High profile research using baboons is part of UMB's research portfolio. Recently, cardiac xenotransplantation research at UMB resulted in a medical breakthrough where the heart of a genetically modified pig was transplanted into a human. This achievement was supported by work done with baboons within UMB's Program for Comparative Medicine and Veterinary Resources (VR) animal facilities. Xenotransplantation may soon be an option for the thousands of people in the United States waiting for transplants, many of whom will die before they receive an organ. Baboons are also used at UMB to study estrogen effects on fetal growth and development as part of a long-term research program in maternal-fetal medicine. As a larger, more sentient species with opposable thumbs, baboon caging, enrichment, welfare, and safety can be quite complex. The groundbreaking xenotransplantation research conducted at UMB is growing, and the need for more animals and new caging has increased. VR's current cage inventory is insufficient to support this growth. In the maternal-fetal research program, breeding animals must be co-housed, which requires flexible cage configurations, larger cages, and additional cages for weaned and juvenile baboons. All animals must be housed in cages of sufficient size to meet the requirements of the Animal Welfare Act Regulations (AWR) and The Guide For The Care And Use Of Laboratory Animals (The Guide). In addition to supporting our growing need for baboons and their housing, modern caging can provide the opportunity for additional enrichment options to improve the welfare and behavioral management of the animals while they are on study. Providing enrichment opportunities to promote species typical behaviors is also a regulatory requirement. Social species of nonhuman primates (NHP) must be housed with other animals unless single housing is justified. This requirement furthers the need for large cages and flexibility in cage configurations that is not consistent with and cannot be achieved with VR's current inventory of baboon cages. Modern caging is also designed with safety features for those who care for and work with these large NHPs. This improves human safety and promotes more productive research with enhanced abilities to safely restrain and manipulate animals in their home cage.