The neural mechanisms and mnemonic consequences of sound processing during sleep

睡眠期间声音处理的神经机制和记忆后果

• 批准号: 10734969
• 负责人: Ada Eban-Rothschild
• 金额: $ 49.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734969
• 关键词: Acoustics; Acute; Address; Amendment; Arousal; Auditory area; Auditory system; Behavioral; Brain; Brain region; Chronic; Communication; Dependence; Dopamine; Electroencephalography; Electrophysiology (science); Event; Exposure to; Familiarity; Health Policy; Hippocampus; Household; Impaired cognition; Impairment; Infant; Investigation; Joints; Knowledge; Light; Link; Memory; Memory impairment; Mus; Names; Neighborhoods; Neurons; Noise; Nucleus Accumbens; Optics; Pattern; Persons; Process; Property; Public Health; Research; Rodent; Role; Semantics; Signal Transduction; Sleep; Sleep disturbances; Stimulus; Testing; Ventral Tegmental Area; Wakefulness; behavioral response; cognitive process; cost; dopaminergic neuron; epidemiology study; experimental study; insight; long term memory; memory consolidation; memory process; memory retention; neural; neuromechanism; neurophysiology; noise exposure; noise pollution; novel; optogenetics; semantic processing; sound; urban setting

Project Summary Despite the overall reduced responsiveness to external stimuli during sleep, incoming sounds are processed by a highly active and broadly projecting auditory system. Moreover, not only the acoustic aspects of sounds are processed during sleep but also their associated meaning, as evidenced by a higher likelihood of awakening from novel and meaningful sounds as compared to familiar and meaningless sounds. These and other findings suggest that there is ongoing semantic neural processing during sleep, yet the underlying brain circuits and neurophysiological mechanisms remain poorly understood. Sound salience processing during sleep enables rapid arousal when a behavioral response is appropriate, such as in the presence of danger or when an infant is in need. However, as millions of people in the US and worldwide live in noisy urban environments, in which they are exposed to household, traffic and other neighborhood sounds during sleep, ongoing processing of sounds during sleep may come at a cost. During sleep in the absence of incoming sounds, brain circuits engage in internally generated neural activity patterns that underlie memory consolidation–the transformation of temporary and labile memory traces into long-term memories. A potential interaction between sound processing and memory processes during sleep has been proposed by recent epidemiological studies which link exposure to nighttime noise and memory impairments. Moreover, we have recently discovered that acute exposure to non-awakening sounds during sleep impairs subsequent memory retention in rodents. However, the acoustic properties of sounds impairing memory consolidation, the consequences of chronic exposure to sounds during sleep on memory capacities and the neural interactions between online sound processing with offline neurophysiological signatures of memory consolidation are largely unknown. We will fill these knowledge gaps using electrophysiological and optical recordings from multiple brain regions, closed-loop sound manipulations and light-activated modulation of neural activity in freely behaving and naturally sleeping mice. In Aim 1, we will determine the role of key brain regions in sound salience processing during wakefulness–the auditory cortex and ventral tegmental area–in processing of sound salience during sleep. In Aim 2, we will determine the acoustic properties of sounds that impair memory processes and the consequences of chronic sound exposure during sleep on memory capacities. In Aim 3, we will determine the acute and chronic consequences of sound processing during sleep on circuit-level neurophysiological mechanisms of memory consolidation. Together, these experiments will provide a mechanistic understanding of the neuronal substrates underlying sound processing during sleep and their mnemonic consequences.

项目摘要 尽管在睡眠期间对外界刺激的反应总体上降低， 由一个高度活跃和广泛投射的听觉系统。此外，不仅声音的声学方面 在睡眠期间被处理，而且它们的相关意义也被处理，正如更高的可能性所证明的那样， 与熟悉和无意义的声音相比，从新奇和有意义的声音中醒来。这些和 其他研究结果表明，在睡眠期间存在持续的语义神经处理， 电路和神经生理机制仍然知之甚少。声音显著性处理 当行为反应适当时，例如在存在危险或 当一个婴儿需要的时候。然而，由于美国和世界各地有数百万人生活在喧闹的城市中， 环境，在这些环境中，他们在睡眠期间暴露于家庭，交通和其他邻居的声音， 在睡眠期间对声音的持续处理可能是有代价的。在睡眠期间，在没有传入的情况下， 声音，大脑回路参与内部产生的神经活动模式，这些模式是记忆的基础 巩固-将暂时和不稳定的记忆痕迹转化为长期记忆。一个潜在 睡眠期间声音处理和记忆过程之间的相互作用已经由最近的 流行病学研究将夜间噪音暴露与记忆障碍联系起来。而且我们 最近发现，在睡眠期间急性暴露于非唤醒声音会损害随后的记忆 在啮齿类动物中的滞留。然而，声音的声学特性损害记忆巩固， 睡眠期间长期暴露于声音对记忆能力和神经相互作用的影响 在线声音处理与离线记忆巩固的神经生理学特征之间的联系， 大部分未知。 我们将使用来自多个大脑区域的电生理和光学记录来填补这些知识空白， 闭环声音操纵和光激活调制的神经活动在自由行为和 自然睡眠的老鼠在目标1中，我们将确定关键大脑区域在声音显著性处理中的作用 在清醒时-听觉皮层和腹侧被盖区-在处理声音的显着性， 睡吧在目标2中，我们将确定损害记忆过程的声音的声学特性， 睡眠期间慢性声音暴露对记忆能力的影响。在目标3中，我们将确定 睡眠期间声音处理对回路水平神经生理学的急性和慢性后果 记忆巩固的机制总之，这些实验将提供一个机械的理解， 睡眠期间声音处理的神经基质及其记忆后果。