Target Promoted Alkylation of Nucleic Acids

目标促进核酸烷基化

• 批准号: 7393199
• 负责人: STEVEN E ROKITA
• 金额: $ 24.44万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393199
• 关键词: Address; Affinity; Alkylation; Base Pairing; Binding; Biochemical; Biological; Biomimetics; Bizelesin; C-glycoside; Chemicals; Complementary DNA; Complex; Cyclophosphamide; DNA; DNA Alkylation; DNA Sequence; Evaluation; Funding; Future; Genes; Genetic Transcription; Glean; Goals; Guidelines; In Vitro; Major Groove; Malignant Neoplasms; Methods; Mustard; Nature; Nucleic Acids; Oligonucleotides; Peptide Nucleic Acids; Process; Proteins; Purines; Pyrimidine; Pyrimidines; RNA; Range; Rate; Reaction; Reagent; Scheme; Single-Stranded DNA; Site; Specificity; System; Testing; Therapeutic; Thermodynamics; Translations; Work; adduct; anticancer treatment; base; cellular targeting; design; experience; in vivo; nucleobase; purine; quinone methide; research study

项目成果

Sequence-specific delivery of a quinone methide intermediate to the major groove of DNA.

将醌甲基化物中间体序列特异性递送至 DNA 大沟。

• DOI: 10.1016/s0968-0896(01)00151-1
• 发表时间: 2001
• 期刊: Bioorganic & medicinal chemistry
• 影响因子: 3.5
• 作者: Zhou,Q;Pande,P;Johnson,AE;Rokita,SE
• 通讯作者: Rokita,SE

Inducible alkylation of DNA by a quinone methide-peptide nucleic acid conjugate.

• DOI: 10.1021/bi201492b
• 发表时间: 2012-02-07
• 期刊: BIOCHEMISTRY
• 影响因子: 2.9
• 作者: Liu, Yang;Rokita, Steven E.
• 通讯作者: Rokita, Steven E.

Targeting duplex DNA with the reversible reactivity of quinone methides.

• DOI: 10.1038/sigtrans.2016.9
• 发表时间: 2016
• 期刊: Signal transduction and targeted therapy
• 影响因子: 39.3
• 作者: Huang C;Liu Y;Rokita SE
• 通讯作者: Rokita SE

Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.

• DOI: 10.1021/ja062948k
• 发表时间: 2006-09
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Emily E. Weinert;R. Dondi;Stefano Colloredo-Melz;Kristen N Frankenfield;Charles H Mitchell;M. Freccero;S. Rokita