The Chemistry-Biology Interface Program at Johns Hopkins University

项目摘要 在两个领域的接口，如化学和生物学研究生培训提供学生 独特的视角和技能，领导基础和应用生物医学研究。两种语言都很流利 领域可以激发跨学科的方法来解决可能不被考虑的问题， 在一个单一领域的传统中。该提案要求重新支持化学 约翰霍普金斯大学（JHU）的生物界面培训计划（CBI）。程序 作为一个独立的学位授予组织运作，已经形成了一个充满活力的社区， 来自公共卫生学院（生物化学和分子生物学），医学 学院（生物物理学和生物物理化学，药理学），克里奇艺术学院和 科学（生物学，生物物理学，化学）和工程学院（化学和 生物分子工程）。从这七个部门中挑选出的教师联合起来， 领导该计划的学术和行政结构。补充资金 由各部门和克里格学校贡献，以帮助维持这一自主计划。 未来的学生直接申请到CBI计划，并在一个队列中到达， 共同课程。课程旨在加强化学的坚实基础， 培养生物科学方面的专业知识。一系列的三个实验室轮换， 部门确保在选择论文顾问之前的研究经验的广度。 参加CBI项目的29名教师提供各种各样的研究课题 包括药物开发、生物无机化学、酶学、核酸和生物分子 结构、装配和动力学。两个学期的化学生物学研究生课程提供核心 CBI计划的指令，也是开放给所有在JHU。学生在CBI中保持活跃 通过参加学生主办的研讨会，文学节目在整个预科 会议和年度务虚会。此外，所有CBI学生参加每月CBI论坛听到 并提出研究更新和独立的建议，以及教师介绍， 有关职业和专业发展的信息。 CBI计划于2005年由大学的种子基金发起，并首次获得 2007年获得国家卫生研究院的支持。这些资金仅够支持5名学生。现时的建议 要求为6名学生提供资金，以减少拒绝合格申请的必要性。在 上一个资助周期，学生保留率非常高（95%），自2010年开始以来超过90%。 程序.

Project Summary Graduate training at the interface of two fields such as chemistry and biology offers students a unique perspective and skills to lead basic and applied biomedical research. A fluency in both fields can inspire cross-disciplinary approaches for solving problems that may not be considered within the traditions of a single field. This proposal requests renewed support for the Chemistry Biology Interface Training program (CBI) at Johns Hopkins University (JHU). The program operates as an independent degree-granting organization that has nucleated a vibrant community of investigators from The School of Public Health (Biochemistry and Molecular Biology), The Medical School (Biophysics and Biophysical Chemistry, Pharmacology), The Kreiger School of Arts and Sciences (Biology, Biophysics, Chemistry) and The School of Engineering (Chemical and Biomolecular Engineering). Select faculty from these seven departments have joined together to lead the academic and administrative structure of this program. Supplementary funds are contributed by the departments and The Krieger School to help sustain this autonomous program. Prospective students apply directly to the CBI program and arrive in a cohort that shares a common curriculum. Courses are designed to reinforce a strong foundation in chemistry while building expertise in the biological sciences. A series of three laboratory rotations across different departments ensures a breadth of experience in research prior to selection of a dissertation advisor. A diverse array of research topics are available from the 29 faculty participating in the CBI program and include drug development, bioinorganic chemistry, enzymology, nucleic acids, and biomolecular structure, assembly and dynamics. A two-semester graduate course in chemical biology offers core instruction for the CBI program and is also open to all at JHU. Students remain active in the CBI program throughout their matriculation by participating in student-hosted seminars, literature meetings and an annual retreat. In addition, all CBI students join the monthly CBI Forum to hear and present research updates and independent proposals as well as faculty introductions and information pertaining to career and professional development. The CBI program was initiated with seed funds from the University in 2005 and first received NIH support in 2007. These funds are sufficient too support only 5 students. The current proposal requests funds for 6 students to reduce the necessity of turning away qualified applications. In the last funding cycle, student retention has been very high (95%) and over 90% since the start of the program.