The Chemistry-Biology Interface Program at Johns Hopkins University

项目摘要 化学和生物等两个领域的研究生培训为学生提供 领导基础和应用生物医学研究的独特视角和技能。两种语言都流利 领域可以激发跨学科的方法来解决可能不被考虑的问题 在单一领域的传统中。这项提议要求重新支持化学 约翰霍普金斯大学(JHU)生物接口培训计划(CBI)。该计划 作为一个独立的学位授予组织运作，它已经形成了一个充满活力的社区 公共卫生学院(生物化学和分子生物学)、医学院的研究人员 学院(生物物理和生物物理化学，药理学)，克里奇艺术和 理科(生物、生物物理、化学)和工程学院(化学和化学) 生物分子工程学)。来自这七个系的精选教员已经联合起来 领导该项目的学术和行政结构。补充资金是 由各部门和克里格学校捐助，以帮助维持这一自主项目。 未来的学生直接申请CBI项目，并在同一批学生中分享 公共课程。课程旨在加强化学方面的坚实基础，同时 积累生物科学方面的专业知识。一系列三个实验室在不同位置的旋转 在选择学位论文导师之前，各系要确保有丰富的研究经验。 参与CBI计划的29名教职员工提供了一系列不同的研究主题 包括药物开发、生物无机化学、酶学、核酸和生物分子 结构、装配和动力学。一个为期两个学期的化学生物学研究生课程提供了核心 CBI项目的指导，也对JHU的所有人开放。学生在CBI保持活跃 通过参加学生主办的研讨会、文学 会议和一年一度的静修。此外，所有CBI学生都会参加每月一次的CBI论坛 并提供最新研究和独立建议以及教师介绍和 有关职业和职业发展的信息。 CBI计划是在2005年用该大学的种子资金发起的，并首次收到 美国国立卫生研究院在2007年提供了支持。这些资金也足够支持只有5名学生。目前的提案 要求为6名学生提供资金，以减少拒绝合格申请的必要性。在 在上一个资助周期，学生保留率非常高(95%)，自开学以来超过90% 程序。

Project Summary Graduate training at the interface of two fields such as chemistry and biology offers students a unique perspective and skills to lead basic and applied biomedical research. A fluency in both fields can inspire cross-disciplinary approaches for solving problems that may not be considered within the traditions of a single field. This proposal requests renewed support for the Chemistry Biology Interface Training program (CBI) at Johns Hopkins University (JHU). The program operates as an independent degree-granting organization that has nucleated a vibrant community of investigators from The School of Public Health (Biochemistry and Molecular Biology), The Medical School (Biophysics and Biophysical Chemistry, Pharmacology), The Kreiger School of Arts and Sciences (Biology, Biophysics, Chemistry) and The School of Engineering (Chemical and Biomolecular Engineering). Select faculty from these seven departments have joined together to lead the academic and administrative structure of this program. Supplementary funds are contributed by the departments and The Krieger School to help sustain this autonomous program. Prospective students apply directly to the CBI program and arrive in a cohort that shares a common curriculum. Courses are designed to reinforce a strong foundation in chemistry while building expertise in the biological sciences. A series of three laboratory rotations across different departments ensures a breadth of experience in research prior to selection of a dissertation advisor. A diverse array of research topics are available from the 29 faculty participating in the CBI program and include drug development, bioinorganic chemistry, enzymology, nucleic acids, and biomolecular structure, assembly and dynamics. A two-semester graduate course in chemical biology offers core instruction for the CBI program and is also open to all at JHU. Students remain active in the CBI program throughout their matriculation by participating in student-hosted seminars, literature meetings and an annual retreat. In addition, all CBI students join the monthly CBI Forum to hear and present research updates and independent proposals as well as faculty introductions and information pertaining to career and professional development. The CBI program was initiated with seed funds from the University in 2005 and first received NIH support in 2007. These funds are sufficient too support only 5 students. The current proposal requests funds for 6 students to reduce the necessity of turning away qualified applications. In the last funding cycle, student retention has been very high (95%) and over 90% since the start of the program.