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AIDS Malignancy Clinical Trials Consortium

AIDS Malignancy Clinical Trials Consortium
艾滋病恶性肿瘤临床试验联盟
批准号:
7689545
负责人:
RONALD T. MITSUYASU
金额:
$24.96万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-08-29 至 2010-07-31
关键词:
1-Phosphatidylinositol 3-Kinase11p15q20q3q213q22.23q22.33q285-(6)-carboxyfluorescein diacetate succinimidyl ester90YAIDS Malignancy ConsortiumAIDS VaccinesAIDS and Cancer Specimen BankAIDS chemotherapyAIDS clinical trial groupAIDS diagnosisAIDS epidemiologyAIDS related cancerAIDS related neoplasmAIDS therapyAIDS with Kaposi&aposs sarcomaAIDS-Related Burkitt&aposs LymphomaAIDS-Related DisorderAIDS-Related Hodgkin&aposs LymphomaAIDS-Related LymphomaAIDS-Related Non-Hodgkin&aposs LymphomaAIDS-Related Primary Central Nervous System LymphomaAbbreviationsAbdomenAberrant DNA MethylationAblationAcademic Medical CentersAcademyAccountabilityAccountingAcquired Immunodeficiency SyndromeAcuteAcute T Cell LeukemiaAddressAdherenceAdjuvantAdministratorAdoptedAdoptive TransferAdrenal Cortex HormonesAdultAdult Burkitt&aposs LymphomaAdvanced Malignant NeoplasmAdverse effectsAdverse eventAdvisory CommitteesAdvisory ServicesAdvocacyAdvocateAffectAffinityAfricaAfrica South of the SaharaAfricanAfrican AmericanAfrican Burkitt&aposs lymphomaAftercareAgeAge-YearsAggressive behaviorAgingAgreementAgricultureAlabamaAldesleukinAlgorithmsAll SitesAllergic ReactionAlternative MedicineAmendmentAmericanAmerican College of SurgeonsAmerican Society of Clinical OncologyAnal Intraepithelial NeoplasiaAnal canalAnal carcinomaAnemiaAnestheticsAngiogenesis InhibitionAngiogenesis InhibitorsAngiogenic FactorAnnexinsAnogenital Human Papilloma Virus InfectionAnogenital cancerAnogenital venereal wartsAnthracycline AntibioticsAnthracyclinesAnti-Retroviral AgentsAntibodiesAntibody AffinityAnticonvulsantsAntigen TargetingAntigensAntineoplastic AgentsAntiretroviral resistanceAntisense OligonucleotidesAntiviral AgentsAntiviral TherapyAntsAnusAplastic AnemiaApoptosisApoptoticAppearanceAppendixApplications GrantsAppointmentArchivesAreaArginine ButyrateArthralgiaArtsAryl Hydrocarbon ReceptorAscaridilAspirate substanceAstheniaAttentionAustraliaAuthorization documentationAutologousAutologous Stem Cell TransplantationAutomobile DrivingAwardAzacitidineB Cell ProliferationB lymphoid malignancyB-Cell ActivationB-Cell LymphomasB-Cell NeoplasmB-Cell NonHodgkins LymphomaB-LymphocytesBCL2L1 geneBMS-275291Bacterial InfectionsBasement membraneBasic ScienceBehaviorBenchmarkingBenefits and RisksBindingBioavailableBiochemicalBioethicsBioinformaticsBiologic CharacteristicBiologicalBiological AssayBiological FactorsBiological MarkersBiologyBiomedical ResearchBiometryBiopsyBiopsy SpecimenBisexualBlindedBloodBlood CellsBlood PlateletsBlood VesselsBlood capillariesBlood donorBlood donor screeningBlood specimenBolus InfusionBone MarrowBone Marrow DiseasesBone Marrow SuppressionBook ChaptersBooksBortezomibBos taurusBostonBowen&aposs DiseaseBowenoid PapulosisBoxingBrainBrassicaceaeBrazilBreast FeedingBritish ColumbiaBryostatin 1/VincristineBudgetsBurkitt LymphomaBurn injuryBusiness RulesBusinessesBusulfanBylawBypassCCI-779CD3 AntigensCD34 geneCD4 Lymphocyte CountCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCD8B1 geneCDE protocol-cyclophosphamide/doxorubicin/etoposideCHK geneCI-1040COL-3CT2103CXCL13 geneCYP2D6 geneCYP3A4 geneCalendarCaliforniaCameroonCancer CenterCancer EtiologyCancer PatientCancer Research ProjectCancer Therapy Evaluation ProgramCancer Trials Support UnitCancer VaccinesCancer cell lineCancer-Related ConditionCapitalCapsidCarcinomaCarcinoma in SituCardiovascular systemCaringCarmustine/Cisplatin/EtoposideCase Report FormCase StudyCaspaseCatalytic RNACategoriesCathetersCattleCause of DeathCell CountCell CycleCell Cycle ProgressionCell DeathCell FractionCell LineCell NucleusCell ProliferationCell SurvivalCellsCellular ImmunityCensusesCentral Nervous System LymphomaCentral Nervous System ProphylaxisCentrosomeCerebrospinal FluidCertificationCervicalCervical Intraepithelial NeoplasiaCervical dysplasiaCervix UteriCervix carcinomaCessation of lifeCetuximabChairpersonCharacteristicsChargeChelating AgentsChemicalsChemosensitizationChemotherapy-Oncologic ProcedureChicagoChickensChildChildhoodChildhood Non-Hodgkin&aposs LymphomaChileChimeric ProteinsChinChinaCholine KinaseChromosomal InstabilityChromosomal translocationChromosome ArmChromosomesChromosomes, Human, Pair 8ChronicChronic Lymphocytic LeukemiaChronic Myeloid LeukemiaCidofovirCisplatinCisplatin/Cytarabine/Etoposide/MethylprednisoloneCisplatin/MitomycinCitiesCivil RightsClassClassificationClinicClinicalClinical DataClinical Data Update SystemClinical EngineeringClinical EthicsClinical InvestigatorClinical ManagementClinical ProtocolsClinical ResearchClinical Research AssociateClinical TreatmentClinical TrialsClinical Trials Cooperative GroupClinical Trials Data Monitoring CommitteesClinical Trials DesignClinical Trials NetworkClinical effectivenessClonal ExpansionClonalityCloningClosureCluster AnalysisCoagulation ProcessCoccidiosisCocosCodeCoffeeCohort StudiesCoinCold TherapyCollaborationsCollagen Type ICollectionColonColon CarcinomaColon, RectumColoradoColorectalColorectal CancerColostomy ProcedureColposcopyCombination ChemotherapyCombined Modality TherapyCombivirCombretastatin A-4Combretastatin A4 Disodium PhosphateCombretastatin A4 PhosphateCommerceCommitCommittee MembersCommittee MembershipCommon Data ElementCommon Terminology Criteria for Adverse EventsCommunicable DiseasesCommunicationCommunitiesCommunity Clinical Oncology ProgramCommunity OutreachCommunity PhysicianCommunity RelationsCompanionsComparative StudyComplementary DNACompletion StatusComplexComprehensive Cancer CenterComputer SystemsComputer Systems DevelopmentComputer softwareComputersConditionConduct Clinical TrialsConfidence IntervalsConfidential InformationConfidentiality of Patient InformationConflict (Psychology)Conflict of InterestConjunctival Squamous Cell CarcinomaConsensusConsentConsent FormsConsultationsContinuous Ambulatory Peritoneal DialysisContinuous InfusionContract ServicesContractsControlled StudyContusionsCore FacilityCorrelation StudiesCorrelative StudyCosmeticsCost AllocationCost SharingCounselingCountCountryCountyCouplesCreamCremophorCross-Sectional StudiesCutaneousCutaneous InvolvementCyclin D1CyclophosphamideCyclophosphamide/Doxorubicin/Etoposide/Prednisone/VincristineCyclosporinsCytarabineCytidine DeaminaseCytochrome P450CytologyCytology HistologyCytomegalovirusCytomegalovirus RetinitisCytotoxic ChemotherapyCytotoxic T-LymphocytesDM-EtDNADNA FingerprintingDNA IntegrationDNA SequenceDNA Sequence RearrangementDNA copy numberDNA-Directed DNA PolymeraseDailyDataData AnalysesData CollectionData QualityData ReportingData SetDatabasesDeath RateDebridementDecision MakingDecision Support SystemsDefectDefective spinal cord developmentDeglutition DisordersDementiaDental ResearchDeoxyribonuclease IDeoxyribonucleasesDepositionDerivation procedureDermalDermatologicDetectionDeveloped CountriesDeveloping CountriesDevelopmentDevelopment PlansDevelopmental Therapeutics ProgramDevicesDiagnosisDiagnosticDiagnostic ImagingDiagnostic Neoplasm StagingDiagnostic ProcedureDiarrheaDidanosineDifferentiation AntigensDiffuseDiffuse Large-Cell LymphomaDigestionDigit structureDigital Rectal ExaminationDirect CostsDisabled PersonsDiscriminationDiseaseDisease OutcomeDisease ProgressionDisease regressionDisease remissionDisease-Free SurvivalDisorder by SiteDisputesDisruptionDisseminated eosinophilic collagen diseaseDistantDistrict of ColumbiaDocetaxel/ThalidomideDoctor of MedicineDoctor of PhilosophyDocumentationDominant-Negative MutationDoseDose-LimitingDouble-Blind MethodDown-RegulationDoxorubicinDoxorubicin/EtoposideDoxorubicin/MethotrexateDoxorubicin/PaclitaxelDropsDrug ApprovalDrug Delivery SystemsDrug EvaluationDrug FormulationsDrug InteractionsDrug KineticsDrug abuseDrug resistanceDrug usageDysmyelopoietic SyndromesDysplasiaE-SelectinEBV-associated malignancyEGF geneESHAP regimenEarly treatmentEastern Cooperative Oncology GroupEdemaEducationEducational workshopEffectivenessEffectiveness of InterventionsElectrocoagulationElectronicsElementsEligibility DeterminationEmergency SituationEmerging Communicable DiseasesEmployeeEncapsulatedEnd PointEndocrinologyEndopeptidasesEndothelial CellsEndpoint DeterminationEnrollmentEnsureEnvironmentEnvironment DesignEnzyme-Linked Immunosorbent AssayEnzymesEpidemicEpidemiologic StudiesEpidemiologistEpidemiologyEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEpithelialEpithelial CellsEpithelial ovarian cancerEpitheliumEpstein-Barr Virus InfectionsEpstein-Barr Virus latencyEpstein-Barr Virus-Related LymphomaEquipmentEquipment and supply inventoriesErbB Receptor Family ProteinErythrocytesErythropoietinEstrogensEtanerceptEthicistsEthicsEtiologyEtoposideEtoposide/IfosfamideEuropeEvaluationEvaluation ReportsEventEvidence Based MedicineEvolutionExanthemaExcisionExhibitsExonsExpenditureExposure toExtracellular MatrixExtracellular Signal Regulated KinasesExtramural ActivitiesExtranodalEye diseasesFaceFacilities and Administrative CostsFacultyFailureFamilyFamily memberFarming environmentFatigueFeedbackFeesFemaleFetusFeverFibrinogenFibroblast Growth FactorFibroblast Growth Factor 2Figs - dietaryFilgrastimFinancial compensationFloridaFlow CytometryFlowersFluorouracilFocus GroupsFollow-Up StudiesForensic MedicineFormalinFosteringFoundationsFoxesFranceFraudFreezingFrequenciesFriendsFringe BenefitFunctional disorderFundingFunding AgencyFunding MechanismsFunding OpportunitiesFutureG-Protein-Coupled ReceptorsGamma RaysGanciclovirGanciclovir/Interleukin-2/ZidovudineGastrointestinal NeoplasmsGastrointestinal Stromal TumorsGaysGelGelatinase AGelatinase BGenderGene ExpressionGene Expression ProfilingGene TargetingGene TransferGene-ModifiedGeneral HospitalsGeneral PopulationGenerationsGeneric DrugsGenesGeneticGenetic PolymorphismGenetic TranscriptionGenomeGenomic InstabilityGenomicsGenotypeGenus CapraGenus ColaGeographyGhanaGillsGlareGlassGleevecGlycolysisGlycoproteinsGoalsGovernmentGraft RejectionGrantGranulocyte Colony-Stimulating FactorGranulocyte-Macrophage Colony-Stimulating FactorGroup AffiliationGroup MeetingsGrowthGrowth FactorGuidelinesGynecologic OncologistGynecologistGynecologyHIF1A geneHIVHIV prevention trials networkHIV-1HairHalf-LifeHalofuginoneHalofuginone HydrobromideHandHarvestHawaiiHeadHead and Neck CancerHead and Neck Squamous Cell CarcinomaHeadacheHealthHealth Insurance Portability and Accountability ActHealth SciencesHealth Services ResearchHealthcareHealthcare SystemsHearingHeatingHelper-Inducer T-LymphocyteHelsinki DeclarationHemangiosarcomaHematologic NeoplasmsHematologistHematologyHematopoietic Cell Growth FactorsHematopoietic Stem Cell MobilizationHematopoietic stem cellsHemorrhageHemorrhoidsHemosiderin DepositionHepaticHepatitis C virusHerpesviridaeHerpesviridae InfectionsHeterosexualsHigh PrevalenceHighly Active Antiretroviral TherapyHistologicHistologyHistone DeacetylaseHistone Deacetylase InhibitorHistopathologyHodgkin DiseaseHollyHome environmentHomologous GeneHomosexualsHospital DepartmentsHospitalsHourHousingHspE7HumanHuman Chorionic GonadotropinHuman Herpesvirus 4Human Herpesvirus 8Human PapillomavirusHuman ResourcesHuman T-lymphotropic virus 1Human immunodeficiency virus testHuman papilloma virus infectionHuman papillomavirus 16Human papillomavirus 6Humoral ImmunitiesHybridsHydroxylationHypergammaglobulinemiaHyperplasiaHypertensionHypoxiaHypoxia Inducible FactorIL2 geneIL6 geneIbritumomab TiuxetanIgEImageImatinibImatinib mesylateImiquimodImmuneImmune System DiseasesImmune responseImmune systemImmunityImmunizationImmunoblastImmunoblottingImmunocompetentImmunoglobulin AImmunoglobulin Class SwitchingImmunoglobulin GImmunoglobulin Somatic HypermutationImmunoglobulin Variable RegionImmunoglobulinsImmunohistochemistryImmunologic Deficiency SyndromesImmunologic MarkersImmunologicsImmunologistImmunologyImmunophenotypingImmunosuppressionImmunotherapeutic agentImmunotherapyImplantIn Situ HybridizationIn VitroIn complete remissionIncentivesIncidenceIncidence StudyIncomeIndinavirIndinavir/Lamivudine/StavudineIndividualInduction of ApoptosisIndustryInfantInfectionInfectious AgentInferiorInflammatoryInformation DisseminationInformation DistributionInformation SystemsInformation TechnologyInformed ConsentInfusion proceduresInjection Site ReactionInjection of therapeutic agentInstitutesInstitutionInstructionInsulin-Like Growth Factor IIntegral Membrane ProteinIntentionInterferon Alfa-2aInterferon Alfa-2bInterferon-alphaInterferonsInterleukin 2 ReceptorInterleukin 6 ReceptorInterleukin-1Interleukin-10Interleukin-12Interleukin-13Interleukin-2Interleukin-3Interleukin-4Interleukin-6InternationalInternational AIDSInternational Agency for Research on CancerInternational AspectsInternational Prognostic IndexInternational UnitInternetInterventionIntervention StudiesIntraepithelial NeoplasiaIntravenousIntravenous infusion proceduresInvasiveInvestigationInvestigational DrugsIrelandIslandIsotretinoinIsraelJNK-activating protein kinaseJointsJournal of the National Cancer InstituteJournalsJusticeKaposi SarcomaKarnofsky Performance StatusKenyaKidneyKidney DiseasesKidney FailureKidney TransplantationKnowledgeLabelLaboratoriesLaboratory ResearchLaboratory StudyLactate DehydrogenaseLamivudine/ZidovudineLaparotomyLarge-Cell Immunoblastic LymphomaLarge-Cell LymphomasLasersLatin AmericaLawsLawyersLeadLeadershipLearningLeftLegal patentLengthLesionLesion by StageLettersLeucovorinLibrariesLicensingLifeLife Cycle StagesLigandsLigationLightLightheadednessLinkLiposomal DoxorubicinLiposomesLiquid substanceLiteratureLiver DysfunctionLiver Function TestsLobbyingLocationLogisticsLong-Term EffectsLos AngelesLow PrevalenceLungLung Kaposi&aposs SarcomaLymphaticLymphatic EndotheliumLymphocyteLymphocyte ActivationLymphocyte CountLymphocyte FunctionLymphocyte antigenLymphoidLymphomaLymphomagenesisLymphopeniaLymphoproliferative DisordersLyticLytic PhaseMAP Kinase GeneMAPK14 geneMEKsMME geneMS4A1 geneMagnetic Resonance ImagingMailsMaintenanceMaizeMalawiMalignant - descriptorMalignant NeoplasmsMalignant Squamous Cell NeoplasmMalignant lymphoid neoplasmMalignant neoplasm of anusMalignant neoplasm of cervix uteriMalignant neoplasm of gastrointestinal tractMalignant neoplasm of lungMalignant neoplasm of ovaryManualsManuscriptsMarrowMarylandMassachusettsMatrix Metalloproteinase InhibitorMatrix MetalloproteinasesMaximum Tolerated DoseMeasurementMeasuresMediatingMediationMedicalMedical HistoryMedical OncologistMedical OncologyMedical RecordsMedical ResearchMedical centerMedicineMelanocytic nevusMeleagris gallopavoMembrane ProteinsMemorial Sloan-Kettering Cancer CenterMental HealthMentorsMessenger RNAMetabolicMetabolic Clearance RateMetabolic PathwayMetadataMethodologyMethodsMethotrexateMethylationMicroarray AnalysisMicrobiologyMid-Career Clinical Scientist Award (K24)MindMinorMinorityMissionMitogen-Activated Protein Kinase InhibitorMitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesMitogensMitomycinMitoticMitotic spindleModalityModelingMole the mammalMolecularMolecular BiologyMolecular EpidemiologyMolecular ProfilingMolecular TargetMonitorMonoclonal AntibodiesMonoclonal Antibody C225MononuclearMoodsMorbidity - disease rateMossesMucositisMulti-Institutional Clinical TrialMulticenter StudiesMulticenter TrialsMulticentric Angiofollicular Lymphoid HyperplasiaMultidrug Resistance GeneMultinational PerspectivesMultiple MyelomaMultivariate AnalysisMusMutationMycobacterium bovisMycobacterium heat-shock protein 65MycosesMyelogenousMyelopoiesisMyelosuppressionMyelosuppressive TherapyN(delta)-acetylornithine, -isomerN-dodecanoylglutamic acid, -isomer, sodium saltNF-kappa BNamesNasopharynx CarcinomaNational Cancer InstituteNational Institute of Allergy and Infectious DiseaseNational Institute of Mental HealthNatural HistoryNatural Killer CellsNatureNeedlesNeeds AssessmentNeoadjuvant TherapyNeoplasmsNeurologicNeurologyNeuropathyNeutropeniaNew AgentsNew YorkNew York CityNewly DiagnosedNewsletterNewspapersNitrogenNodalNodular LesionNon-Hodgkin&aposs LymphomaNon-Small-Cell Lung CarcinomaNone or Not ApplicableNormal tissue morphologyNorth CarolinaNot DefinedNotificationNuclearNucleosidesNude MiceNumbersNursesNursing ResearchObject AttachmentObstetrics DepartmentsOccupational activity of managing financesOffice ManagementOffice of ManagementOhioOintmentsOkadaic AcidOligonucleotidesOncogene ActivationOncogene ProteinsOncogenesOncogenicOncogenic VirusesOncologistOncology GroupOnline SystemsOpen Reading FramesOperating RoomsOperative Surgical ProceduresOpportunistic InfectionsOralOrganOrgan TransplantationOther Agency or OrganizationOther Working GroupsOutcomeOutcome MeasureOutcome StudyOutpatientsOxygenPDGF inhibitionPDGFRB genePIK3CA genePIK3CB genePTPRC genePaclitaxelPainPalate Kaposi&aposs 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measurementPlatelet-Derived Growth FactorPlatelet-Derived Growth Factor ReceptorPlayPliabilityPodophyllotoxinPolandPoliciesPolyarthritidesPolymerasePolymerase Chain ReactionPolymersPopulationPopulation ControlPopulation GroupPopulation StudyPopulations at RiskPositioning AttributePositron-Emission TomographyPovertyPre-studyPrecancerous ConditionsPredictive FactorPredispositionPrednisonePregnancyPregnancy TestsPremalignantPremedicationPreparationPresbyterian ChurchPress ReleasesPrevalencePrevalence StudyPreventionPrevention approachPrevention strategyPreventivePrimary Care PhysicianPrimary Health CarePrimary NeoplasmPrimary carcinoma of the liver cellsPrincipal InvestigatorPrintingPrior ChemotherapyProceduresProcessProcollagen-Proline DioxygenaseProctitisProductionProductivityProfessional counselorPrognostic FactorPrognostic MarkerProgram Research Project GrantsProgram ReviewsProgress ReportsProgression-Free SurvivalsProgressive DiseaseProliferatingProlinePropertyProphylactic 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pathologymonocytemortalitymouse modelmulticatalytic endopeptidase complexmycobacterialmycophenolate mofetilneoplasm registryneoplasticneoplastic cellneovascularizationneutrophilnewsnon-nucleoside reverse transcriptase inhibitorsnovelnovel strategiesnovel therapeuticsnucleoside analogolder patientoncologyoptical imagingorganizational structureoutcome forecastovarian neoplasmoxaliplatinp27 Cell Cycle Proteinp27 Enzyme Inhibitorp65pandemic diseaseparacrineparkin gene/proteinpartial responsepathogenpatient safetypaymentpeerpenisperformance siteperipheral bloodpilot trialplacebo controlled studyplatelet-derived growth factor BBpol genesposterspre-clinicalpreclinical studypreconditioningpreventprofessorprogenitorprogesterone 11-hemisuccinate-(2-iodohistamine)prognosticprogramspromoterprospectiveprotein expressionprotocol developmentquality assuranceradiation resistancerandomized placebo controlled trialranpirnasereceptorreceptor downregulationreceptor 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DESCRIPTION (provided by applicant): The Group Chair' office of the AIDS Malignancy Consortium (AMC) is located in the UCLA Center for Clinical AIDS Research and Education (CARE Center), located at 9911 Pico Blvd, Ste 980, Los Angeles, CA 90035. The AMC is a clinical trials cooperative group established to evaluate new clinical interventions for the treatment and prevention of malignancies in HIV. The mission of the AMC is to improve the therapy of malignancies in HIV and to develop new and more effective treatment and prevention approaches. Dr. Ronald Mitsuyasu, the AMC Group Chair, is Director of the UCLA CARE Center and Professor of Medicine in the Division of Hematology-Oncology at UCLA. Dr. Mitsuyasu is responsible for the coordination, overall function, scientific direction, and fiscal accountability of the AMC. With input from the AMC working groups, Executive Committee and NCI Program Director, he sets the scientific agenda and oversees the execution of the AMC's protocols and other scientific endeavors. He chairs all meetings and conference calls of the Executive and Steering Committees, interacts with all components of the AMC and is the primary representative of the group to other oncology and HIV clinical trials groups, the AIDS Cancer and Specimen Resource (ACSR) and the NIAID Managing Partner Committee. Dr. Mitsuyasu will be assisted by a Project Manager who will coordinate the functions of the various group components and will maintain communications between the Group Chair and the sites, operations center, statistics center and core labs. She will also represent the Group Chair on working group calls and review protocols for accuracy and completeness prior to their being released to the sites. A project assistant will arrange and take minutes for all AMC conference calls and perform secretarial duties for the Group Chair and Project Manager. A project analyst will be responsible for monitoring all aspects of the finances of the group and preparing fiscal reports for the NCI. Malignancies are a growing problem in immune deficient HIV patients, and cancer remains one of the major causes of morbidity and mortality in AIDS patients. The AIDS Malignancy Consortium (AMC) conducts studies to improve the treatment of cancers in HIV disease. The AMC Group Chair's office is responsible for coordinating and overseeing all aspects of the functioning of the AMC.
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