Racial and social contextual factors in relation to epigenome and bladder cancer outcome.

与表观基因组和膀胱癌结果相关的种族和社会背景因素。

• 批准号: 10762268
• 负责人: Nagireddy Putluri
• 金额: $ 4万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762268
• 关键词: Address; African American; African American population; American; Antineoplastic Agents; Behavior; Biological; Biological Factors; Biology; Biomedical Research; Cancer Patient; Cancer Research Project; Carcinogens; Categories; Censuses; Characteristics; Clinical; Collaborations; Communities; Community Developments; Community Health; Comprehensive Cancer Center; Consent; Cross-Sectional Studies; Cystectomy; DNA; DNA Methylation; Data; Data Set; Development; Disadvantaged; Disease Progression; Disparate; Disparity; Drug Kinetics; Economics; Education; Environment; Environmental Risk Factor; Environmental and Occupational Exposure; Epigenetic Process; Ethnic Origin; European; Event; Exhibits; Faculty; Functional disorder; Genes; Geographic Information Systems; Health; Health Services Accessibility; Historically Black Colleges and Universities; Housing; Human; Incidence; Individual; Industry; Inferior; Infrastructure; Institution; Intervention; Interview; Interviewer; Joints; Life Cycle Stages; Link; Location; Malignant Neoplasms; Malignant neoplasm of urinary bladder; Measures; Mediating; Medicine; Methylation; Minority Groups; Modification; Molecular and Cellular Biology; Neighborhoods; Neoplasm Circulating Cells; Neoplasm Metastasis; Occupational; Occupational Exposure; Outcome; Outcome Measure; Pathway interactions; Patients; Persons; Pilot Projects; Plants; Play; Policies; Policy Research; Printing; Prognostic Marker; Public Health; Race; Recording of previous events; Reporting; Research; Resource Sharing; Risk; Role; Rubber; Running; Smoking History; Social Environment; Source; Specimen; Surveys; Testing; Texas; Textiles; Tissue Sample; Tumor Bank; U.S. Department of Housing and Urban Development; Universities; Work; Workplace; Xenobiotics; anticancer research; built environment; cancer health disparity; carcinogenicity; college; community engagement; contextual factors; drug discovery; education research; epigenome; epigenomics; ethnic minority; experience; health care availability; health data; health disparity populations; member; methylation pattern; mortality; neighborhood disadvantage; outreach; programs; racial disparity; racial minority; recruit; social culture; social factors; social health determinants; socioeconomics; software systems; stressor; timeline; tumor; tumor progression

CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU), an institution serving underserved health disparity populations and a historically black college and university (HBCU), to establish the Baylor-Texas Southern P20 consortium or BCM-TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED). BCM-TSU P20 CURED will develop the infrastructure for a cancer research program with a specific focus on cancer health disparities (including biology, outcomes, and access to treatment) and community engagement with a joint Cancer Research Education Program. This collaboration builds upon complementary expertise in cancer health disparities at DLDCCC/BCM and TSU, cancer drug discovery and pharmacokinetics at TSU, and robust patient and community- focused outreach and engagement focused on predominantly minority populations of both institutions with complementary expertise and allowance of shared resources and ongoing joint endeavors with both institutions. The proposal for BCM-TSU P20 CURED includes the Center of Excellence for Housing and Community Development Policy Research (CEHCDPR), a U.S. Department of Housing and Urban Development Center of Excellence, at TSU as a member of the research team. Faculty with CEHCDPR will partner with faculty from the Department of Molecular and Cellular Biology at BCM to study the associations between the social determinants of health (SDOH) and bladder cancer to understand the racial disparities in disease progression, in which African Americans experience more severe outcomes than Whites. CEHCDPR will develop a SDOH interviewer-administered survey that will include questions about socioeconomic characteristic, smoking history, and health care access, and residential and workplace history. BCM will administer the survey to consenting bladder cancer patients. Once BCM has completed the survey, CEHCDPR will use Geographic Information Systems software to geolocate each patient’s historical residential location. CEHCDPR will compile data layers from existing sources, including US Census and US EPA, on the socioeconomic and environmental conditions of the patient’s residential neighborhoods. Concurrently, BCM will run DNA testing of tissue samples from the patients who completed the survey. The CEHCDPR and BCM datasets will be combined and CEHCDPR will analyze the data to evaluate the association between the SDOH and the cancer DNA data.

CURED PILOT项目2摘要 这项建议需要加强丹L邓肯综合癌症中心 贝勒医学院（Baylor College of Medicine）和德克萨斯南方大学（Texas Southern University）（大津）的一个机构 服务于服务不足的健康差距人口和历史上的黑人学院和大学（HBCU）， 建立Baylor-Texas Southern P20联盟或BCM-TSU P20癌症合作联盟 研究，教育和差异（治愈）。BCM-TSU P20 CURED将开发基础设施， 癌症研究计划，特别关注癌症健康差异（包括生物学，结果， 和获得治疗）和社区参与联合癌症研究教育计划。 这种合作建立在DLDCCC/ESTA癌症健康差异的互补专业知识的基础上 和大津大学，大津大学的癌症药物发现和药代动力学，以及强大的患者和社区- 有针对性的外联和接触，重点是两个机构的主要少数群体 具有互补的专业知识和允许共享资源和正在进行的共同努力， 两个机构。 BCM-TSU P20 CURED的提案包括住房和社区卓越中心 发展政策研究（CEHCDPR），美国住房和城市发展中心部 优秀，在大津作为研究团队的一员。与CEHCDPR的教师将与教师合作 来自分子和细胞生物学系的研究人员， 健康的社会决定因素（SDOH）和膀胱癌，以了解疾病的种族差异 进展，其中非洲裔美国人比白人经历更严重的结果。CEHCDPR将 开发一个SDOH访谈管理的调查，将包括社会经济问题， 特征、吸烟史、卫生保健获得、居住和工作场所史。车身控制模块将 对同意的膀胱癌患者进行调查。一旦完成调查， CEHCDPR将使用地理信息系统软件来地理定位每个患者的历史 住宅位置。CEHCDPR将从现有来源编译数据层，包括美国人口普查和 美国环保署，对病人的住宅区的社会经济和环境条件。 同时，卫生部将对完成调查的病人的组织样本进行DNA检测。 将合并CEHCDPR和CEHCDPR数据集，CEHCDPR将分析数据以评估 SDOH和癌症DNA数据之间的关联。