Racial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder Cancer
与欧洲膀胱癌相比,非裔美国人膀胱癌的种族差异以及代谢改变的鉴定
基本信息
- 批准号:9388440
- 负责人:
- 金额:$ 37.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-06-05 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcetylationAcetyltransferaseAddressAfrican AmericanAlcohol dehydrogenaseAmericanAspartic AcidBioenergeticsBiologicalBiological FactorsBiological MarkersCancer PatientCancer cell lineCaringClinicalCystectomyDataDevelopmentDiagnosticDiseaseDisease OutcomeDisease ProgressionEnzymesEuropeanGenerationsGenesGeneticGleanGliomaGlutaminaseGlutamineHypermethylationIn VitroIncidenceIronIsocitrate DehydrogenaseLabelLipidsMalignant neoplasm of urinary bladderMarital StatusMass Spectrum AnalysisMeasurementMeasuresMessenger RNAMetabolicMetabolic MarkerMetabolic PathwayMetabolismMethodologyMitochondriaMuscleMutationNAT1 geneOccupational ExposureOncogenicOutcomePathway interactionsPatient-Focused OutcomesPatientsPatternPharmaceutical PreparationsPharmacologyPhospholipase A1PhosphorylcholinePilot ProjectsPositioning AttributeProteinsPublicationsPublishingRaceReportingResearchRoleSEER ProgramSeminalSmokerSmokingSocioeconomic FactorsTechniquesTherapeuticTissuesUrineXenobiotic MetabolismXenograft procedurebasecancer health disparitycombinatorialexperienceglutaric acidhealth care availabilityhealth disparityin vivoinhibitor/antagonistlecithin-retinol acyltransferaselipid metabolismmetabolomemetabolomicsmitochondrial metabolismmortalityprognosticracial disparityracial health disparitytherapeutic targettreatment strategytriple-negative invasive breast carcinomatumortumor progression
项目摘要
Project Summary/Abstract
It has known that bladder cancer (BCa) mortality is higher in African American patients. Disparity exists
between African-American (AA) and European-American (EA), in the clinical outcome of BCa. The long-term
objective of our research plan is to reduce the disproportionate effects of bladder cancer (BCa) on African
American. A guiding principle of our methodology is that alterations in mitochondrial metabolites exist between
African American and European American BCa and that these differences can explain, in part, BCa health
disparity. In this application, we propose to use the technique of metabolomic profiling to uncover these
underlying differences. To date, a metabolomic analyses aimed at understanding of bladder cancer health
disparity has not been reported. We have recently published the first study describing metabolic alterations
associated with bladder cancer. In preliminary studies, we have profiled the metabolome of BCa from AA and
EA patients and identified a distinct AA race-specific expression pattern in mitochondrial metabolites and lipids.
In this proposal, we will i) characterize the mitochondrial associated metabolites in AA and EA BCa, ii) verify
the D-2HG and associated enzymes (GLS, ADHFE1, and IDH1/2) in BCa patients and establish a
therapeutically targeted deregulation pathway for glutamine metabolism in AA BCa iii) assess the levels of lyso
PC and PC and the function of their metabolizing enzymes PLA1A and LRAT in AA BCa. The successful
completion of the proposed studies will have a significant impact in the field of Bladder cancer health disparity
and metabolism. Importantly, findings from our study have the potential to reveal racially exclusive metabolic
markers and therapeutic targets for BCa. Taken together, the information gleaned from this proposal could
rapidly revolutionize current diagnostic, prognostic and therapeutic approaches by revealing the biological
underpinnings of bladder cancer health disparity.
项目摘要/摘要
它已经知道,非裔美国人的膀胱癌(BCA)死亡率更高。贫富差距存在
在BCA的临床结局中,非裔美国人(AA)和欧洲裔美国人(EA)之间的差异。长期的
我们研究计划的目标是减少膀胱癌(BCA)对非洲人的不成比例影响
美国人。我们方法学的指导原则是线粒体代谢物的改变存在于
非洲裔美国人和欧洲裔美国人的BCA,这些差异可以部分解释BCA的健康
贫富差距。在这个应用中,我们建议使用代谢组谱技术来揭示这些
潜在的差异。迄今为止,一项旨在了解膀胱癌健康状况的代谢分析
目前还没有关于差异的报道。我们最近发表了第一项描述代谢变化的研究
与膀胱癌有关。在初步研究中,我们已经描绘了来自AA和BCA的代谢组
EA患者,并在线粒体代谢物和脂类中发现了明显的AA小种特异性表达模式。
在这个方案中,我们将:i)表征AA和EA BCA中的线粒体相关代谢物,ii)验证
BCA患者D-2HG及其相关酶(GLS、ADHFE1和IDH1/2)的检测
针对AA患者谷氨酰胺代谢的治疗靶向性去调节途径III)评估溶血素水平
PC和PC及其代谢酶PLA1A和LRAT在AA BCA中的作用。成功者
拟议研究的完成将对膀胱癌健康差距领域产生重大影响
和新陈代谢。重要的是,我们的研究结果有可能揭示种族排斥的新陈代谢
BCA的标志物和治疗靶点。综上所述,从这项提案中收集的信息可能
通过揭示生物学特征,迅速革新当前的诊断、预测和治疗方法
膀胱癌健康差异的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nagireddy Putluri其他文献
Nagireddy Putluri的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nagireddy Putluri', 18)}}的其他基金
Racial and social contextual factors in relation to epigenome and bladder cancer outcome.
与表观基因组和膀胱癌结果相关的种族和社会背景因素。
- 批准号:
10762268 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
相似海外基金
Investigating the functions of histone acetylation in genome organization and leukemogenesis
研究组蛋白乙酰化在基因组组织和白血病发生中的功能
- 批准号:
EP/Y000331/1 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Research Grant
Gene Modulation of Acetylation Modifiers to Reveal Regulatory Links to Human Cardiac Electromechanics
乙酰化修饰剂的基因调节揭示与人类心脏机电的调节联系
- 批准号:
10677295 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Novel roles of PDK2 in heart failure: Regulation of mitochondrial nuclear crosstalk via metabolic regulation and histone acetylation
PDK2 在心力衰竭中的新作用:通过代谢调节和组蛋白乙酰化调节线粒体核串扰
- 批准号:
10635599 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Regulation of hepatic lysine N-acetylation by cysteine proximity due to alcohol toxicity
酒精毒性导致的半胱氨酸接近对肝脏赖氨酸 N-乙酰化的调节
- 批准号:
10752320 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Histone Acetylation Regulates Microglial Innate Immune Memory
组蛋白乙酰化调节小胶质细胞先天免疫记忆
- 批准号:
478927 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Operating Grants
Dysregulation of Histone Acetylation in Parkinson's Disease
帕金森病中组蛋白乙酰化的失调
- 批准号:
10855703 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
Obesity-related hypertension: the contribution of PPAR gamma acetylation and asprosin
肥胖相关高血压:PPAR γ 乙酰化和白脂素的贡献
- 批准号:
10654210 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
The role N-terminal acetylation in dilated cardiomyopathy and associated arrhythmia
N-末端乙酰化在扩张型心肌病和相关心律失常中的作用
- 批准号:
10733915 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
In vivo tracing of hepatic ethanol metabolism to histone acetylation: role of ACSS2 in alcohol-induced liver injury
肝脏乙醇代谢与组蛋白乙酰化的体内追踪:ACSS2 在酒精性肝损伤中的作用
- 批准号:
10667952 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别:
The function of TWIST1 acetylation in cell fate and tissue development
TWIST1 乙酰化在细胞命运和组织发育中的作用
- 批准号:
10726986 - 财政年份:2023
- 资助金额:
$ 37.07万 - 项目类别: