Applying a multidimensional measure of human mobility to understand drivers of HIV incidence in Rakai, Uganda
应用多维人口流动性衡量指标来了解乌干达拉凯艾滋病毒发病率的驱动因素
基本信息
- 批准号:10761906
- 负责人:
- 金额:$ 4.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAfrica South of the SaharaAfricanAgeAreaAvidityBiological AssayBiological MarkersCaliberCase/Control StudiesCategoriesClimateCohort StudiesCommunicable DiseasesCommunitiesCountryDataData AnalysesDedicationsDimensionsEconomicsEpidemicEpidemiologic MethodsExhibitsFaceFrequenciesFutureGenderGoalsHIVHIV InfectionsHIV SeronegativityHIV riskHealthHealth Services AccessibilityHomeHouseholdHumanHuman immunodeficiency virus testIncidenceIndividualInstitutionInterventionInvestigationKnowledgeLearningLinkLocationLongitudinal StudiesLongitudinal SurveysLongitudinal cohortMeasuresMentorshipMethodsMotivationMovementNational Institute of Mental HealthOdds RatioOutcomeParentsParticipantPartner NotificationPathway AnalysisPatternPersonsPoliticsPopulationPopulation ResearchPopulation StudyPrevalencePreventionQuestionnairesReligionResearchResearch PersonnelResourcesRiskSamplingSelection BiasService delivery modelServicesSexual PartnersSubgroupSurvey MethodologySurveysTestingTrainingTravelTreatment outcomeUgandaUniversitiesUnsafe SexViral Load resultVirusVisitWorkagedbarrier to carecareercohortcommunity transmissionexperiencefollow-upimprovedlongitudinal analysismHealthmigrationpoor health outcomepopulation basedpopulation healthpopulation movementpre-exposure prophylaxisprevention serviceprogramsresearch data disseminationresponseself testingservice deliveryskillssocialsocial epidemiologyspatial epidemiologytransmission processtreatment adherencewasting
项目摘要
PROJECT SUMMARY/ABSTRACT
Background. As sub-Saharan African (SSA) countries embark on the last mile toward HIV elimination, HIV
programs must prioritize hard-to-reach mobile populations at the greatest risk of HIV acquisition and onward
transmission. Some differentiated service delivery models may work for mobile people, but targeting services to
such a broad category of individuals could waste limited resources. Since it is unclear which forms of mobility
most significantly increase the risk of HIV infection, this study aims to systematically characterize mobility and
relate it to HIV incidence at both the individual and sexual network levels. Aims. In line with NIMH Human
Mobility and HIV program objectives to determine incidence rates and examine HIV outcomes among mobile
populations, this study will 1) characterize mobility and its association with HIV testing and viral load suppression,
2) estimate HIV incidence by mobile group, and 3) determine the effect of mobility on the risk of HIV acquisition
in sexual networks. Elucidating these gaps will inform future targeting and tailoring of interventions to improve
the health of mobile populations. Approach. Since no consistent measure for mobility exists across HIV studies
in SSA, this research will use detailed mobility metrics from the Rakai Community Cohort Study (RCCS), a
population-based longitudinal study in south-central Uganda where there is substantial human movement, to
develop a multidimensional measure that considers the frequency, duration, motivation, and spatial dimensions
to people’s movement. This measure will uncover subclasses of mobility that can be linked to HIV incidence and
other prevention and treatment outcomes. RCCS data from 19,300 adults aged 15-49 will be supplemented with
data from Hard-to-Reach (HTR), an embedded study within the RCCS that captures HIV outcomes and mobility
patterns among 2,000 individuals who have been lost to follow-up (LTFU) in the RCCS. This presents a unique
opportunity to assess the missing data biases introduced by population mobility in open, dynamic cohorts. Each
Specific Aim will use the full extent of the available data, including longitudinal HIV biomarkers and detailed
contact investigations conducted among HIV incident cases and their HIV-negative matched controls. Training.
Ms. Khalifa’s training plan leverages her quantitative abilities and HIV research experience to advance her skills
and launch her into a career as an independent investigator focused on mobility and health. Her training goals
are to develop in-depth knowledge of mobility and migration, gain experience with longitudinal survey methods,
learn advanced epidemiologic techniques for missing data and network analyses, and build capacity for effective
research dissemination. Under the guidance of her Primary Sponsor, Ms. Khalifa will receive tailored mentorship
from a team of experienced HIV researchers who work with the parent studies, conduct mobility-focused
research, and have tremendous expertise in the requisite quantitative methods. Training will take place at
Columbia University, a high-caliber institution with specialized research programs in population health, infectious
disease, and spatial and social epidemiology.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aleya R Khalifa其他文献
Aleya R Khalifa的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
ESE: Collaborative Research: Climate Change and Variability and Armed Conflicts in Africa South of the Sahara
ESE:合作研究:撒哈拉以南非洲的气候变化和变异性以及武装冲突
- 批准号:
0964515 - 财政年份:2010
- 资助金额:
$ 4.6万 - 项目类别:
Standard Grant
Network Dynamics, Sexual Behaviour, and HIV Among University Students in Africa South of the Sahara
撒哈拉以南非洲大学生的网络动态、性行为和艾滋病毒
- 批准号:
178094 - 财政年份:2008
- 资助金额:
$ 4.6万 - 项目类别:
Studentship Programs
Synopsis of Ichneumoniae of Africa, South of the Sahara
撒哈拉以南非洲的姬蜂病简介
- 批准号:
66B2956 - 财政年份:1966
- 资助金额:
$ 4.6万 - 项目类别:
To Attend Synopsis of Ichneumoninae of Africa, South of the Sahara
参加撒哈拉以南非洲的姬蜂亚科概要
- 批准号:
65B2956 - 财政年份:1965
- 资助金额:
$ 4.6万 - 项目类别:














{{item.name}}会员




