Integration of Compliance Chambers into Diaphragm Displacement Pump to Double the Pumping Flow of Pediatric Paracorporeal Pulsatile Ventricular Assist Device
将顺应室集成到隔膜排量泵中,使儿科体外脉动心室辅助装置的泵流量加倍
基本信息
- 批准号:10761399
- 负责人:
- 金额:$ 29.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-10 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAortaApicalBerlinBiotechnologyBloodBlood flowCannulasCardiacCardiogenic ShockCardiomyopathiesChildChildhoodComplexCoupledDataDevicesDiastoleDrainage procedureEngineeringFDA approvedFrequenciesGlycerolGoalsHeadHeartHeart TransplantationHeart failureHousingImplantInfusion proceduresInterruptionKentuckyLaboratory Animal Production and FacilitiesLungMembraneMoldsMotorMovementMyocarditisPatientsPerformancePhasePolyurethanesPublicationsPulsatile FlowPumpResearch SupportRespiratory DiaphragmScientistSiliconesSmall Business Innovation Research GrantStressSurgeonSystemSystoleTechnologyTestingThrombosisTimeTraumaTricuspid valve structureUniversitiesVacuumWeightWithdrawalbiomaterial compatibilityblood damageblood pumpcommercializationcongenital heart disorderdesignexperiencefabricationflexibilityhemocompatibilityimprovedimproved outcomein vivoinnovationinventionleft ventricular assist devicelight weightminimally invasivemultidisciplinaryneonatenovelpediatric heart failurepediatric patientspolycarbonatepressureprototyperesearch and developmentshear stressventricular assist device
项目摘要
The paracorporeal Berlin Heart EXCOR is the only FDA-approved ventricular assist device (VAD) for
pediatric patients. This pulsatile diaphragm displacement pump (DDP) is small/light weight to facilitate pediatric
patient ambulation. However, EXCOR efficiency is only 50% since it withdraws and pumps blood at different
times (interrupted pulsatile flow). This generates a high peak blood flow rate, which may cause blood damage.
A paracorporeal continuous flow PediMag VAD has also been used in smaller children. This centrifugal pump
is highly efficient due to the constant flow through the drainage/infusion cannulas, but the PediMag pump head
must be attached to a bulky/heavy motor, which hinders ambulation. We previously developed a transapical to
aorta (TAA) double lumen cannula (DLC) for a minimally invasive ambulatory LVAD, which showed excellent
96 hr performance/hemocompatibility in neonate lambs. Our ultimate goal is to develop an efficient, minimally
invasive, paracorporeal LVAD system for pediatric patients, which combines the small size/weight (ambulation
potential) of current interrupted pulsatile flow pump (e.g EXCOR) and the current high efficiency of a
continuous flow pump (e.g PediMag). The enabling technology is a compliant diaphragm displacement pump
(cDDP), which has compliance chambers integrated into the drainage and infusion outlets to double blood flow.
The cDDP will be high performing due to: 1) noninterrupted/continuous blood flow; 2) infusion/drainage
compliance chambers that decrease cDDP afterload/increase cDDP preload. The lower peak drainage/infusion
flow of the cDDP will also reduce blood trauma. Preliminary data showed that adding compliance chambers
increased pumping flow from 1.1 to 2.6 L/min and decreased peak flow rate. The Phase I SBIR objective is to
design and fabricate a cDDP working prototype with optimal compliance chambers size. This cDDP will be
tested in lambs with our previously developed TAA DLC. Specific Aim 1: To design, fabricate, and bench
test a cDDP. Compliance chambers will be integrated into the cDDP drainage and infusion outlets. The cDDP
will be made of polycarbonate housing with a polyurethane diaphragm in the middle. A tricuspid valve will
connect the cDDP housing to the two small silicone compliance chambers. The final prototype will be tested for
1 week in a 37% glycerin mock loop for performance/reliability/durability. Specific Aim 2: To test the cDDP
working prototype in lambs. The cDDP will be combined with the TAA DLC to form a less invasive,
ambulatory LVAD, which will be tested in 10-15 kg lambs (n=9) to evaluate 6 hr performance/reliability and
initial biocompatibility. Prototype design/fabrication/bench testing will be done at W-Z Biotech, and the lamb
studies will be done at the University of Kentucky. Rather than fine-tuning existing technology, our cDDP is a
novel invention, which will enable a pulsatile paracorporeal VAD with doubled efficiency. This technology can
also be used in adults and may significantly impact cardiogenic shock/bridge to heart transplant management.
paracorreal Berlin Heart EXCOR是唯一获得fda批准的心室辅助装置(VAD)
项目成果
期刊论文数量(0)
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Stephen R Topaz其他文献
Stephen R Topaz的其他文献
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{{ truncateString('Stephen R Topaz', 18)}}的其他基金
Pediatric Transapical Double Lumen Cannula with Integrated Compliance Chambers Doubles Flow of Paracorporeal Pulsatile VAD
带有集成顺应室的儿科经心尖双腔插管使体外脉动 VAD 的流量加倍
- 批准号:
10699790 - 财政年份:2023
- 资助金额:
$ 29.59万 - 项目类别:
Development of a Minimally Invasive Single Cannulation, Compact Single Port Pulsatile Ventricular Assist Device (sppVAD) for Total LV Support
开发用于全面左心室支持的微创单插管、紧凑型单端口脉动心室辅助装置 (sppVAD)
- 批准号:
10259308 - 财政年份:2021
- 资助金额:
$ 29.59万 - 项目类别:
Development of Percutaneous DLC for Total Cavo-pulmonary Assistance
用于全 Cavo 肺辅助的经皮 DLC 的开发
- 批准号:
9141450 - 财政年份:2016
- 资助金额:
$ 29.59万 - 项目类别:
Development of TransApical to Aorta Double Lumen Cannula for a Neonate LVAD
用于新生儿 LVAD 的经心尖至主动脉双腔插管的开发
- 批准号:
8712075 - 财政年份:2014
- 资助金额:
$ 29.59万 - 项目类别:
Development of a TransApical to Aorta Double Lumen Cannula for a Neonate LVAD
用于新生儿 LVAD 的经心尖至主动脉双腔插管的开发
- 批准号:
9555884 - 财政年份:2014
- 资助金额:
$ 29.59万 - 项目类别:
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