Ultra-dense ceramic scintillator for BrainPET scanner

用于 BrainPET 扫描仪的超致密陶瓷闪烁体

• 批准号: 10761208
• 负责人: JAROSLAW GLODO
• 金额: $ 27.52万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-04 至 2024-08-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10761208
• 关键词: Address; Affect; Benchmarking; Biological Process; Brain; California; Ceramics; Characteristics; Charge; Collaborations; Detection; Development; Diameter; Electronics; Elements; Evaluation; Exhibits; Goals; Growth; Human; Image; Imaging Device; LSO crystal; Length; Light; Lutetium; Methods; Monitor; Monte Carlo Method; Neurosciences Research; Outcome; Performance; Phase; Polishes; Positron-Emission Tomography; Production; Property; Resolution; Surface; System; Techniques; Thick; Time; Translating; Universities; Yttrium; brain based; brain metabolism; cost; density; design; detector; experimental study; fabrication; human disease; human subject; improved; in vivo; instrumentation; luminescence; manufacture; manufacturing cost; neurochemistry; next generation; prototype; simulation

Summary Positron emission tomography (PET) is a powerful tool for imaging a wide range of biological processes in vivo and for detecting and monitoring human disease, as well as an important technique in neuroscience research. For human brain studies, PET offers a sensitive and noninvasive window into brain metabolism and neurochemistry, providing information from living human subjects that cannot be obtained using any other technique. The key characteristics of brain PET are spatial resolution and sensitivity. Brain PETs with a spatial resolution approaching 1 mm at the center of the field-of-view (FOV) are under development using LYSO or LSO scintillators, which are the currently available scintillators that can provide the best overall performance. However, to obtain a high sensitivity, which strongly affects the quantitative precision of PET imaging, L(Y)SO with a thickness of around 20 mm is widely used. The first and the major drawback of using the thick L(Y)SO crystal is the parallel error, which decreases the spatial resolution off the center of the FOV. Depth-of-Interaction (DOI) information can be used to improve spatial resolution off the center of the FOV, however, the best DOI resolution from 20 mm thick L(Y)SO is ~2.0 mm obtained using the dual-ended readout, which is not good enough. The second drawback of the L(Y)SO is the high cost. For most scanners, the L(Y)SO cost is half of the total scanner cost. The performance of brain PET scanners can be improved using a new scintillator based on Lu2O3 (LO), which has a higher density (9.4 vs. 7.4 g/cm3 for LSO) and higher effective Z (68 vs. 65 for LSO). When doped with La3+ and Yb3+, it exhibits an ultra-fast rise time (<0.6ns) combined with prompt charge transfer luminescence with decay time of 1.7 ns, giving timing resolution (TR) of 180 ps FWHM. The energy resolution at 511 keV is better than 10% (>10% for LYSO), due to the good light yield from slower components (<20,000 ph/MeV) and good proportionality (better than for LYSO). Hence, LO:La,Yb can be an excellent choice for a brain PET scanner requiring high sensitivity and high spatial resolution. The LO is produced using ceramic methods which may also have an edge over the crystal growth methods in terms of cost of manufacturing. Therefore, for this project, we propose to 1) optimize the LO:La,Yb and its manufacturing for high-resolution and high-sensitivity brain PET applications, 2) optimize LO:La,Yb based PET detector for brain PET through experimental evaluation, and 3) to estimate the performance of a full brain PET system based on these results through GATE Monte Carlo simulations and benchmark it against LYSO system.

总结 正电子发射断层扫描（PET）是一种强大的工具，成像范围广泛的生物 用于检测和监测人类疾病，以及重要的 神经科学研究技术。对于人脑研究，PET提供了一个敏感的， 非侵入性的大脑代谢和神经化学窗口，提供生活信息， 人类受试者无法使用任何其他技术获得。的关键特征 脑PET是空间分辨率和灵敏度。空间分辨率接近 使用LYSO或LSO正在开发视场（FOV）中心1 mm的 制冷剂，这是目前可用的制冷剂，可以提供最好的整体 性能然而，为了获得高灵敏度，这强烈影响了定量分析。 为了提高PET成像的精度，广泛使用厚度为20 mm左右的L（Y）SO。 使用厚L（Y）SO晶体的第一个和主要缺点是平行误差， 降低FOV中心以外的空间分辨率。交互深度（DOI）信息 可以用来提高FOV中心以外的空间分辨率，但是， 从20 mm厚的L（Y）SO获得的分辨率为~2.0 mm，使用双端读出， 还不够好L（Y）SO的第二个缺点是成本高。对于大多数扫描仪， L（Y）SO成本占扫描仪总成本的一半。 脑PET扫描仪的性能可以使用基于以下的新闪烁体来改进： Lu 2 O3（LO），其具有更高的密度（9.4 g/cm 3，LSO为7.4 g/cm 3）和更高的有效Z（68，LSO为7.4 g/cm 3）。 LSO为65）。当掺杂La ~（3+）和Yb ~（3+）时，它具有超快的上升时间（<0.6ns） 具有快速电荷转移发光，衰减时间为1.7 ns，提供时序分辨率（TR） 180 ps FWHM。在511 keV处的能量分辨率优于10%（对于LYSO>10%），这是由于 来自较慢组分的良好光产率（<20，000 ph/MeV）和良好的比例性（优于 LYSO）。因此，L0：La，Yb可以是用于需要高分辨率的脑PET扫描仪的极好选择。 高灵敏度和高空间分辨率。LO使用陶瓷方法生产， 在制造成本方面也具有优于晶体生长方法的优势。 因此，对于本项目，我们建议1）优化LO：La，Yb及其制造， 高分辨率和高灵敏度脑PET应用，2）优化基于LO：La，Yb的PET 通过实验评估脑PET探测器，以及3）评估 全脑PET系统的基础上，这些结果通过门蒙特卡罗模拟和 以LYSO系统为基准。