Nitric oxide Releasing Ultra-Slippery Antibacterial Surfaces for Urological Catheter Applications
用于泌尿导管应用的一氧化氮释放超光滑抗菌表面
基本信息
- 批准号:10759903
- 负责人:
- 金额:$ 33.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-15 至 2024-07-14
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAffectAnti-Bacterial AgentsAnti-Infective AgentsAntibiotic TherapyBacteremiaBacteriaBacterial AdhesionBacteriuriaBiocompatible MaterialsBiologicalBusinessesCannulasCatheterizationCathetersCell LineCell SurvivalChronicClinicalDataDevelopmentDevicesDisinfectionElderlyEnsureEscherichia coliFormulationFortuneGoalsGrowthGuidelinesHealth Care CostsHospitalizationHospitalsHumanIn VitroIndustrializationIndwelling CatheterInfectionInflammationInfusion proceduresKidneyLeadLength of StayLettersLiquid substanceMalignant neoplasm of urinary bladderMammalian CellMarketingMechanicsMedicalMedical DeviceMethodsMicrobial BiofilmsN-acetylpenicillamineNitric OxideNitric Oxide DonorsNursing HomesOperative Surgical ProceduresPatientsPeritoneal DialysisPhasePolymersPopulationProbabilityProceduresPropertyProteinsProteus mirabilisPyelonephritisRiskSilicone OilsSmall Business Innovation Research GrantSurfaceSurface PropertiesTechnologyTubeUnited States National Institutes of HealthUrinary CatheterizationUrinary Incontinenceacute pyelonephritisaging populationantimicrobialcatheter associated UTIcommercializationcookingcytotoxicendotrachealexperiencehealthcare-associated infectionsinfection riskinsightinterestmechanical propertiesmedical complicationpreventresponseurinaryurologic
项目摘要
Abstract
Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only
increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used
in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to
infection. Catheter associated urinary tract infections (CAUTIs) account for nearly 40% of all healthcare
associated infections (HAIs) and can lead to extended hospital stays for patients which in turn leads to higher
healthcare costs. To overcome this risk of infection, a catheter surface that is able to prevent bacterial adhesion
and biofilm formation while simultaneously eliminating planktonic bacteria present in the vicinity is highly
desirable. However, no long-term catheter solution has been able to accomplish this goal. Nytricx, Inc. has
developed proprietary methods and know-how developing anti-infective nitric oxide (NO) releasing interfaces
capable of effectively eliminating a wide variety of bacterial strains while being able to elicit no cytotoxic response
from mammalian cell lines. Nytricx, Inc. has also demonstrated that the liquid-infusion of silicone oil to create a
super slippery surface is able to prevent the adhesion of proteins and bacteria and thus eliminate biofilms. A
synergistic antimicrobial response is achieved by combining liquid-infused strategy and NO releasing polymers
(LINORel). The overall objective of this Phase I SBIR application is to create a long-term highly antimicrobial
urinary catheter through a combination of impregnating Foley catheters with a NO donor, S-nitroso-N-
acetylpenicillamine (SNAP), with a liquid-infused silicone oil interface and to evaluate commercialization
feasibility in terms of mechanical and biological properties.
摘要
导尿管是医院环境中使用最广泛的医疗器械之一,
由于人口老龄化而增加。在各种常用的生物医学设备中
在临床环境中,导尿管与最大部分的医疗并发症有关,
感染导尿管相关性尿路感染(CITTI)占所有医疗保健的近40%
相关感染(HAI),并可能导致患者住院时间延长,进而导致更高的
医疗费用。为了克服这种感染的风险,导管表面能够防止细菌粘附
和生物膜形成,同时消除存在于附近的浮游细菌,
令人向往然而,没有长期的导管解决方案能够实现这一目标。Nytricx,Inc.具有
开发专有方法和专有技术,开发抗感染的一氧化氮(NO)释放界面
能够有效消除多种细菌菌株,同时不引起细胞毒性反应,
从哺乳动物细胞系。Nytricx,Inc.还证明了硅油的液体注入可以产生
超滑表面能够防止蛋白质和细菌的粘附,从而消除生物膜。一
通过组合液体注入策略和NO释放聚合物实现协同抗微生物反应
(LINORel).这一阶段SBIR应用的总体目标是创造一种长期的高抗菌性
导尿管通过浸渍Foley导管与NO供体,S-亚硝基-N-
乙酰青霉胺(SNAP)与液体注入硅油界面,并评价商业化
在机械和生物性能方面的可行性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ronald J. Shebuski其他文献
Induction of neointimal hyperplasia by coronary angioplasty balloon overinflation: comparison of feeder pigs to Yucatan minipigs.
冠状动脉血管成形术球囊过度充气诱导新内膜增生:饲养猪与尤卡坦小型猪的比较。
- DOI:
10.1016/0002-8703(94)90505-3 - 发表时间:
1994 - 期刊:
- 影响因子:4.8
- 作者:
William R. Humphrey;Carol A. Simmons;Christopher F. Toombs;Ronald J. Shebuski - 通讯作者:
Ronald J. Shebuski
Ronald J. Shebuski的其他文献
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{{ truncateString('Ronald J. Shebuski', 18)}}的其他基金
Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters
超低结垢抗感染抗血栓释放一氧化氮血管内导管
- 批准号:
10759671 - 财政年份:2020
- 资助金额:
$ 33.74万 - 项目类别:
Localized Delivery of Sirolimus to Vascular Grafts
西罗莫司局部递送至血管移植物
- 批准号:
8251068 - 财政年份:2012
- 资助金额:
$ 33.74万 - 项目类别:
Development of Platelet & Coagulation Activation Assays
血小板的发育
- 批准号:
6402965 - 财政年份:2001
- 资助金额:
$ 33.74万 - 项目类别:
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