Nitric oxide Releasing Ultra-Slippery Antibacterial Surfaces for Urological Catheter Applications

摘要 导尿管是医院中使用最广泛的医疗设备之一，预计只有 由于人口老龄化，增长速度加快。在所有经常使用的各种生物医学设备中 在临床环境中，导尿管与与以下疾病相关的大部分医疗并发症有关 感染。导管相关性尿路感染(CAUTIs)占所有医疗保健的近40% 相关感染(HAI)，并可导致患者延长住院时间，进而导致更高的 医疗保健成本。为了克服这种感染风险，能够防止细菌粘连的导管表面 和生物膜的形成，同时消除附近存在的浮游细菌 令人向往。然而，没有一种长期的导管解决方案能够实现这一目标。Nytricx，Inc. 开发专有方法和技术开发抗感染性一氧化氮(NO)释放接口 能够有效地清除多种细菌菌株，同时不会引起细胞毒性反应 从哺乳动物细胞系中分离出来。Nytricx公司还证明，液体输注硅油可以创造出一种 超光滑的表面能够防止蛋白质和细菌的粘连，从而消除生物膜。一个 通过液体输注策略和NO释放聚合物相结合实现协同抗菌反应 (LINORel)。此第一阶段SBIR应用的总体目标是创建一种长期的高度抗菌 经组合浸渍Foley导尿管与NO供体，S-亚硝基-N- 乙酰青霉胺(SNAP)，具有液体注入硅油界面，并评估商业化 在机械和生物性能方面的可行性。

Abstract Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to infection. Catheter associated urinary tract infections (CAUTIs) account for nearly 40% of all healthcare associated infections (HAIs) and can lead to extended hospital stays for patients which in turn leads to higher healthcare costs. To overcome this risk of infection, a catheter surface that is able to prevent bacterial adhesion and biofilm formation while simultaneously eliminating planktonic bacteria present in the vicinity is highly desirable. However, no long-term catheter solution has been able to accomplish this goal. Nytricx, Inc. has developed proprietary methods and know-how developing anti-infective nitric oxide (NO) releasing interfaces capable of effectively eliminating a wide variety of bacterial strains while being able to elicit no cytotoxic response from mammalian cell lines. Nytricx, Inc. has also demonstrated that the liquid-infusion of silicone oil to create a super slippery surface is able to prevent the adhesion of proteins and bacteria and thus eliminate biofilms. A synergistic antimicrobial response is achieved by combining liquid-infused strategy and NO releasing polymers (LINORel). The overall objective of this Phase I SBIR application is to create a long-term highly antimicrobial urinary catheter through a combination of impregnating Foley catheters with a NO donor, S-nitroso-N- acetylpenicillamine (SNAP), with a liquid-infused silicone oil interface and to evaluate commercialization feasibility in terms of mechanical and biological properties.