Polymer Nanocomposite Materials with Enhanced Properties for Medical Tubing

用于医用管材的具有增强性能的聚合物纳米复合材料

• 批准号: 7499604
• 负责人: Naima Bestaoui-Spurr
• 金额: $ 5.67万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499604
• 关键词: Area; Arteries; Arts; Caliber; Carbon; Cardiovascular system; Catheters; Chemical Structure; Condition; Data; Decompression Sickness; Development; Dimensions; Electric Wiring; Employee; Engineering; Evaluation; Filler; Gases; Glass; Glycol; Glycols; Government; Inorganic Chemistry; Invasive; Location; Manufacturer Name; Marketing; Mechanics; Medical; Medical Device; Methods; Microtomy; Modification; Muscle Rigidity; Nature; New England; Operative Surgical Procedures; Particle Size; Penetration; Permeability; Persons; Pharmaceutical Preparations; Phase; Physicians; Polymers; Preparation; Principal Investigator; Procedures; Process; Property; Published Comment; Purpose; Research; Risk; Rupture; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Sterilization for infection control; Structure; Surface; Technology; Tensile Strength; Thick; Time; Torque; Trauma; Travel; Tube; Work; base; clay; experience; improved; melting; nanocomposite; nanomaterials; particle; physical property; pressure; scale up; size; skills; tool; zirconium phosphate

DESCRIPTION (provided by applicant): In many medical applications, the enhancements required for medical devices are mechanical in nature. State-of-the-art, highly engineered medical devices allow physicians to perform procedures noninvasively that were previously possible only through surgery. The push to make procedures less and less invasive has put considerable pressure on medical tubing manufacturers to reduce the diameter and wall thickness of medical tubing used to make catheters and stint delivery balloons. To maintain the physical and mechanical properties of the tubing and avoid the risk of rupture, fillers are added to reinforce the polymer from which the tubing is made. The particle size of traditional polymer-reinforcing fillers such as glass, carbon and other fibrous materials are far too large to be suitable for thin walls required for the most modern of miniature medical devices. This Phase I SBIR proposal describes the preparation of a clay-like inorganic material/ polymer nanocomposite to be used in the manufacture of thin-wall, small diameter medical tubing. Polymer nanocomposites are ideally suited for this application and only a few percent (2 to 5 wt. %) of the layered material is needed to considerably reinforce the properties of the polymer. The biggest challenge in the development of the nanocomposite materials is the extensive exfoliation of the inorganic layered material into the polymer to obtain a homogenous material with continuous properties. Most nanofillers are simply intercalated into the polymer, not exfoliated. The proposed nanomaterials are ideally suited for exfoliation within medically relevant polymers and will yield particle surface areas greater then 700 m2/g - a value which greatly exceeds the surface area of current state-of-the-art, intercalated nanofillers.

描述（由申请人提供）：在许多医疗应用中，医疗器械所需的增强本质上是机械的。最先进的、高度工程化的医疗设备使医生能够无创地完成以前只能通过手术才能完成的手术。为了使手术过程的侵入性越来越小，医用导管制造商面临着相当大的压力，他们不得不减少用于制造导管和限位输送气球的医用导管的直径和壁厚。为了保持管材的物理和机械性能，并避免破裂的风险，需要添加填料来增强制成管材的聚合物。传统的聚合物增强填料，如玻璃、碳和其他纤维材料的粒径太大，不适合用于最现代的微型医疗设备所需的薄壁。第一阶段SBIR提案描述了一种粘土状无机材料/聚合物纳米复合材料的制备，用于制造薄壁、小直径医用管。聚合物纳米复合材料非常适合这种应用，只需要百分之几（2到5重量%）的层状材料就可以显著增强聚合物的性能。纳米复合材料发展的最大挑战是将无机层状材料大量剥离到聚合物中，以获得具有连续性能的均质材料。大多数纳米填料只是简单地嵌入到聚合物中，而不是剥离。所提出的纳米材料非常适合于医学上相关聚合物的剥离，并将产生大于700 m2/g的颗粒表面积，这一值大大超过了当前最先进的插层纳米填料的表面积。