Advanced Vestibular Evoked Myogenic Potential (VEMP) Screening and Testing System

项目描述（由申请人提供）：本项目旨在开发先进的前庭诱发肌电位（VEMP）筛选和测试设备。VEMP测试已被认为是一种间接测量小囊、部分耳石、下前庭神经或其他小囊中枢连接功能完整性的方法。目前，VEMP是通过标准的听觉诱发电位（AEP）系统获得的，这些系统不能对记录一致和有效的VEMP反应所需的背景肌电活动提供足够的控制。该系统将作为智能听力系统制造的集成听力和前庭评估的AEP系统SmartEP中的VEMP特定模块，或作为小型便携式VEMP设备，用于前庭筛查、测试、耳毒性监测和其他相关应用。在第一阶段，开发并测试了一个VEMP模块，该模块结合了背景肌电监测和患者反馈以及用于测试儿童的视频显示强化。chain - stimulation和CLAD高刺激率测试技术也成功地应用于VEMP测试。并对采集参数和数据分析参数进行了优化。二期将进行全面的临床试验，获得300名受试者的规范性数据。计算机控制的颅骨敲击刺激器和骨振动头带也将开发，以方便使用这些技术进行VEMP测试。拟议的设备将通过标准化VEMP反应的获取对公共卫生产生直接影响，VEMP反应在集成测试模块中提供了对球囊功能的独特和客观测试。VEMP测试已成为一种重要和有效的程序，以检测功能完整性的球囊和下前庭神经。所提出的VEMP系统的使用有望大大提高VEMP检测的临床效用和数据质量。因此，拟议的工作将通过开发更好的VEMP检测系统，极大地影响公共卫生。

DESCRIPTION (provided by applicant): The purpose of the project is to develop an advanced Vestibular Evoked Myogenic Potential (VEMP) screening and testing device. VEMP testing has been recognized as an indirect measure of the functional integrity of the saccule, a portion of the otoliths, the inferior vestibular nerve or other central connections of the saccule. VEMPs are currently acquired using standard Auditory Evoked Potential (AEP) systems which do not provide adequate controls over background EMG activity required to record consistent and valid VEMP responses. The proposed system will be made available either as a VEMP specific module within SmartEP, an AEP system manufactured by Intelligent Hearing Systems, integrating hearing and vestibular assessment, or as a compact portable VEMP device to be used for vestibular screening, testing, ototoxicity monitoring and other related applications. During Phase I, a VEMP module incorporating background EMG monitoring and patient feedback with video display reinforcement for testing children was developed and tested. Chained-Stimuli and CLAD high stimulation rate testing techniques were also successfully applied to VEMP testing. Acquisition and data analysis parameters were also optimized. During Phase II, a comprehensive clinical trial will be conducted to obtain normative data from 300 subjects. A computer controlled skull tap stimulator and bone vibrator headband will also be developed to facilitate VEMP testing using these techniques. The proposed device will have a direct impact on public health by standardizing the acquisition of VEMP responses, which provide a unique and objective test of saccule function, in an integrated testing module. VEMP testing has emerged as an important and valid procedure that detects the functional integrity of the saccule and the inferior vestibular nerve. The use of the proposed VEMP system is expected to greatly improve the clinical utility and data quality of VEMP testing. As such, the proposed work will greatly impact public health by developing better VEMP testing systems.